Results 91 to 100 of about 24,233,392 (378)

Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1

Journal of Biological Chemistry, 2018
Inflammatory cell death, or pyroptosis, is triggered by pathogenic infections or events. It is executed by caspase-1 (in the canonical pyroptosis pathway) or caspase-11 (noncanonical pathway), each via production of a cell-lytic domain from the ...
Monica L Gonzalez Ramirez, M. Poręba, S. Snipas, Katarzyna Groborz, M. Drąg, G. Salvesen   +5 more
semanticscholar   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Galactose:PEGamine coated gold nanoparticles adhere to filopodia and cause extrinsic apoptosis [PDF]

, 2018
Ultra-small gold nanoparticles, surface functionalised with a 50:50 ratio of a thiolated α-Galactose derivative and a thiolated hexaethylene glycol amine, are toxic to HSC-3 oral squamous carcinoma cells.
Espinosa Garcia, Cristina, Golding, Jon, Tzelepi, Konstantina, Williams, Phil   +3 more
core   +1 more source

INAUGURAL ARTICLE by a Recently Elected Academy Member:Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1

, 2018
Canonical inflammasomes are cytosolic supramolecular complexes that activate caspase-1 upon sensing extrinsic microbial invasions and intrinsic sterile stress signals. During inflammasome assembly, adaptor proteins ASC and NLRC4 recruit caspase-1 through
Yang Li, T. Fu, A. Lu, K. Witt, J. Ruan, Chen Shen, Hao Wu   +6 more
semanticscholar   +1 more source

Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18

PLoS Pathogens, 2018
Infection with Burkholderia pseudomallei or B. thailandensis triggers activation of the NLRP3 and NLRC4 inflammasomes leading to release of IL-1β and IL-18 and death of infected macrophages by pyroptosis, respectively.
Jinyong Wang, M. Sahoo, L. Lantier, Jonathan M. Warawa, H. Cordero, Kelly Deobald, F. Re   +6 more
semanticscholar   +1 more source

Dual Role of Caspase-11 in Mediating Activation of Caspase-1 and Caspase-3 under Pathological Conditions [PDF]

The Journal of Cell Biology, 2000
Caspase-11, a member of the murine caspase family, has been shown to be an upstream activator of caspase-1 in regulating cytokine maturation. We demonstrate here that in addition to its defect in cytokine maturation, caspase-11–deficient mice have a reduced number of apoptotic cells and a defect in caspase-3 activation after middle cerebral artery ...
Junying Yuan, Nancy A. Thornberry, Zhihong Huang, Anu Srinivasan, Erin P. Peterson, Kevin J. Tomaselli, Shobu Namura, Suyue Wang, Hideaki Hara, Shin Jung Kang, Sepideh Amin-Hanjani, Michael A. Moskowitz   +11 more
openaire   +2 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Apoptotic gene expression in neuropathic pain [PDF]

, 2008
Pain initiated or caused by a primary lesion or dysfunction in the nervous system is defined as neuropathic pain. It results from direct injury to nerves in the peripheral or central nervous system and is associated with several clinical symptoms ...
Annalucia Migliozzi, Carlo Fuccio, Catia Giordano, Dario Siniscalco, Francesco Rossi, Livio Luongo, Sabatino Maione   +6 more
core   +2 more sources

Microparticulate Caspase 1 Regulates Gasdermin D and Pulmonary Vascular Endothelial Cell Injury

American Journal of Respiratory Cell and Molecular Biology, 2018
&NA; Lung endothelial cell apoptosis and injury occur throughout all stages of acute lung injury/acute respiratory distress syndrome and impact disease progression.
S. Mitra, M. Exline, F. Habyarimana, M. Gavrilin, P. Baker, S. Masters, M. Wewers, A. Sarkar   +7 more
semanticscholar   +1 more source

Activation of Caspase-1 in the Nucleus Requires Nuclear Translocation of Pro-caspase-1 Mediated by Its Prodomain [PDF]

Journal of Biological Chemistry, 1998
The interleukin-1beta-converting enzyme-like protease precursor, pro-caspase-1, has an N-terminal prodomain that is removed during cleavage activation of the protease. Here we show that tumor necrosis factor treatment of HeLa cells induced apoptosis without detectable proteolytic activation of caspase-1 in the cytosol.
Mao, P.-L., Jiang, Y., Wee, B.Y., Porter, A.G.   +3 more
openaire   +3 more sources