Results 101 to 110 of about 504,320 (308)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Inflammatory caspase substrate specificities

mBio
Caspases are a family of cysteine proteases that act as molecular scissors to cleave substrates and regulate biological processes such as programmed cell death and inflammation.
Patrick M. Exconde, Christopher M. Bourne, Madhura Kulkarni, Bohdana M. Discher, Cornelius Y. Taabazuing   +4 more
doaj   +1 more source

Regulation of the Apaf-1/Caspase-9 Apoptosome by Caspase-3 and XIAP [PDF]

Journal of Biological Chemistry, 2003
The apoptosome is a multiprotein complex comprising Apaf-1, cytochrome c, and caspase-9 that functions to activate caspase-3 downstream of mitochondria in response to apoptotic signals. Binding of cytochrome c and dATP to Apaf-1 in the cytosol leads to the assembly of a heptameric complex in which each Apaf-1 subunit is bound noncovalently to a ...
Hua, Zou, Ruomei, Yang, Junshan, Hao, Jean, Wang, Chaohong, Sun, Stephen W, Fesik, Joe C, Wu, Kevin J, Tomaselli, Robert C, Armstrong   +8 more
openaire   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Caspase-8 and Apaf-1-independent Caspase-9 Activation in Sendai Virus-infected Cells [PDF]

Journal of Biological Chemistry, 2002
Apoptotic cell death is of central importance in the pathogenesis of viral infections. Activation of a cascade of cysteine proteases, i.e. caspases, plays a key role in the effector phase of virus-induced apoptosis. However, little is known about pathways leading to the activation of initiator caspases in virus-infected host cells.
Bitzer, M, Armeanu, S, Prinz, F, Ungerechts, G, Wybranietz, W, Spiegel, M, Bernlohr, C, CECCONI, FRANCESCO, Gregor, M, Neubert, WJ, Schulze Osthoff, K, Lauer, UM   +11 more
openaire   +6 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Brainiac Caspases: Beyond the Wall of Apoptosis [PDF]

, 2019
For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as regulators of apoptosis or inflammation to having a wider range of functions.
Alonso Bellido, Isabel María, Burguillos García, Miguel Ángel, Espinosa Oliva, Ana María, García Revilla, Juan   +3 more
core   +1 more source

AB0049 Evaluation of caspase-3, caspase-9, caspase-14 and pannexin-1 levels in behÇet's disease [PDF]

Annals of the Rheumatic Diseases, 2018
Background Behcet’s disease (BD) is a rheumatic disease in which various systemic findings such as especially recurrent oral afts, and genital ulcers, eye involvement, skin lesions, gastrointestinal involvement, neurological involvement, vascular involvement and arthritis can be seen.1 The pathogenesis of the disease has not yet been fully understood.
A. İlhan, M.E. Derin, I. Karadağ, H.O. Doğan, A.C. Urhan, M. Şahin, A. Şahin   +6 more
openaire   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Caspase-9 swings both ways in the apoptosome

Molecular & Cellular Oncology, 2017
For nearly 2 decades, investigators have debated whether cysteinyl-aspartate-specific protease 9 (caspase-9) is activated within the apoptotic protease-activating factor 1 (Apaf-1) apoptosome through proximity-induced homodimerization or through ...
Chu-Chiao Wu, Shawn B. Bratton
doaj   +1 more source