Results 161 to 170 of about 509,167 (309)

Novel perspectives on non-canonical inflammasome activation

ImmunoTargets and Therapy, 2015
Catherine Emma Diamond,1,2 Hanif Javanmard Khameneh,1 David Brough,2 Alessandra Mortellaro,1 1Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore; 2Faculty of Life Sciences, University of Manchester ...
Diamond CE, Khameneh HJ, Brough D, Mortellaro A   +3 more
doaj  

Epstein‐Barr Virus Expressed Long Non‐Coding RNA (lncBARTs) Regulate EBV Latent Genome Replication

Advanced Science, EarlyView.
EBV produces abundant level of lncBARTs, which are essential for maintaining viral genome replication in EBV‐associated cancers. LncBARTs interact with a complex comprising BRD4, CTCF and viral protein EBNA1 at EBV oriP region. This interaction tethers oriP to host chromosomes, facilitating EBV episome replication.
Jiayan Liu, Dittman Lai‐Shun Chung, Larry Ka‐Yue Chow, Shuo Han, Wenkai Yi, Conor J. Cremin, Yingyin Liao, Pui Wang, Bobo Wing‐Yee Mok, Mingfang Ji, Jian Yan, Wei Dai, Honglin Chen   +12 more
wiley   +1 more source

Microbial Modulation of Host Apoptosis and Pyroptosis

Frontiers in Cellular and Infection Microbiology, 2014
Yongqun Oliver eHe, Amal O Amer
doaj   +1 more source

Induction of ASC pyroptosis requires gasdermin D or caspase-1/11-dependent mediators and IFNβ from pyroptotic macrophages [PDF]

, 2020
Cuiping Zhang, Caiqi Zhao, Xiaohong Chen, Rujia Tao, Sijiao Wang, Guangxun Meng, Xing Liu, Changzhou Shao, Xiao Su   +8 more
openalex   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Bcl-2 Blocks a Caspase-Dependent Pathway of Apoptosis Activated by Herpes Simplex Virus 1 Infection in HEp-2 Cells

, 2000
Verónica Galván, Renato Brandimarti, Joshua Munger, Bernard Roizman   +3 more
openalex   +2 more sources

Anti-apoptotic Activity of Ginsenoside Rb₁in Hydrogen Peroxide-treated Chondrocytes: Stabilization of Mitochondria and the Inhibition of Caspase-3 [PDF]

, 2012
Ji-Young Na, Sokho Kim, Kibbeum Song, Kyu-Hee Lim, Gee-Wook Shin, Jong‐Hoon Kim, Bumseok Kim, Young‐Bae Kwon, Jungkee Kwon   +8 more
openalex   +1 more source

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

Advanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin, Shengcai Yang, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu, Quanshun Li   +6 more
wiley   +1 more source

Investigation of caspase-1 activity and interleukin-1β production in murine macrophage cell lines infected with Leishmania major

, 2014
Mohammad Reza Mahmoudian Sani, Mehrdad Moosazadeh Moghaddam, Hossein Aghamollaei, Kazem Hassanpour, Ramezan Ali Taheri, Gholamreza Farnoosh   +5 more
openalex   +1 more source

Junduqing extractive promotes the apoptosis of nasopharyngeal carcinoma cells through down-regulating Mcl-1 and Bcl-xL and up-regulating Caspase-3, Caspase-8 and Caspase-9 [PDF]

, 2019
Weiguo Zhao, Lei Tang, Shan Gao, Ling Xin, Haiyong Zhang, Yunjing Li   +5 more
openalex   +1 more source