Results 181 to 190 of about 509,167 (309)

Picroside II Alleviates the Progression of Alzheimer's Disease via the NLRP3/Caspase-1/GSDMD Pathway. [PDF]

Neuromolecular Med
Li S, Gao Y, Zhang Y, Zhang J, Zhao Y, Chang C, Gao X, Zhang J, Yang G.   +8 more
europepmc   +1 more source

Antitumor Effects of Berberine on Gliomas via Inactivation of Caspase-1-Mediated IL-1β and IL-18 Release [PDF]

, 2019
Lei Tong, Chuncheng Xie, Yafen Wei, Yunyue Qu, Hongsheng Liang, Yiwei Zhang, Tianye Xu, Xin Qian, Huijia Qiu, Haoyu Deng   +9 more
openalex   +1 more source

Seipin‐Mediated Lipid Droplet Formation in Cardiomyocytes Ameliorates Cardiac Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
Lipid droplets (LDs) protect the heart against lipotoxicity in cardiac ischemia/reperfusion (I/R) injury; however, they are insufficient to prevent cardiomyocyte death. Seipin plays a central role in the insufficient formation of LDs, subsequent lipotoxicity, and myocardial injury during cardiac I/R injury.
Changyun Liu, Junxia Zhang, Yusi Chen, Geng Shen, Yufei Han, Zihao Zhou, Jinxuan Chen, Xuya Kang, Huilin Qu, Jiaxin Duanmu, Haibao Shang, Yingjia Li, Wei Huang, Yan Zhang   +13 more
wiley   +1 more source

Predictive Value of Pyroptosis Markers (NLRP3, HMGB1, and Caspase-1) in the Prognosis of Patients With Metastatic Breast Cancer: A Prospective Observational Study. [PDF]

Breast J
Zhang Y, He Y, Liu Q, Deng H.
europepmc   +1 more source

Artemisinin attenuated ischemic stroke induced pyroptosis by inhibiting ROS/TXNIP/NLRP3/Caspase-1 signaling pathway

Yue Wang, Huiling Yuan, Da Shen, Shuyuan Liu, Weiao Kong, Keying Zheng, Jiehong Yang, Lijun Ge   +7 more
openalex   +1 more source

PLA2G16‐Mediated Tetracosatetraenoic Acid Rewires Fatty Acid Oxidation to Impair CD8+ T Cell Immune Function in Promoting Breast Cancer Lung Metastasis

Advanced Science, EarlyView.
Illustrating how tumor‐derived PLA2G16 regulates tetracosatetraenoic acid (C24:4 (n‐6)) accumulation and CD8+ T cell activation via the C24:4‐PPARα‐FAO axis in early metastatic niches, thereby promoting lung metastasis of triple‐negative breast cancer.
Yubi Gan, Die Meng, Lei Lang, Jing Luo, Peijin Dai, Chao Chang, Zexiu Lu, Yuetong Guo, Rui Wang, Shanchun Chen, Xi Tang, Yixuan Hou, Dongmei Tan, Manran Liu   +13 more
wiley   +1 more source

Curcumin exerts therapeutic effects on colorectal cancer by inducing pyroptosis through caspase‑1 activation. [PDF]

Mol Med Rep
Zhu J, Yang L, Fang Z, Chen J, Wu Y, Liu H, Liu S, Fei B.   +7 more
europepmc   +1 more source

Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells

Advanced Science, EarlyView.
Alkyltriphenylphosphonium, exemplified by TPP+‐C14, preferentially accumulates in mitochondria and selectively binds to cardiolipin, a key phospholipid of the inner mitochondrial membrane, causing loss of mitochondrial membrane potential, severe cellular ATP depletion, and calcium imbalance.
Jin Li, Hang Zheng, Yuxing Lin, Ziwei Zhao, Yijia Mai, Zhangrong Lou, Qiang Liu, Zhao Ma, Chengjun Wu   +8 more
wiley   +1 more source

Novel strategies for PEDV to interfere with host antiviral immunity through Caspase-1. [PDF]

Virulence
Shi W, Xu W, Lv Q, Zhang Z, Fu X, Li D, He S, Wang Y, Xu J, Liu S, Ge Y, Li P, Ou C, Li X, Shi F.   +14 more
europepmc   +1 more source

Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer [PDF]

, 2017
Maria Laura Pati, John R. Hornick, Mauro Niso, Francesco Berardi, Dirk Spitzer, Carmen Abate, William G. Hawkins   +6 more
openalex   +1 more source