HIV-1 envelope induces activation of caspase-3 and cleavage of focal adhesion kinase in primary human CD4+T cells [PDF]
, 2000 Claudia Cicala +6 more
openalex +1 more source
NOX2 Contributes to High‐Frequency Outer Hair Cell Vulnerability in the Cochlea
Advanced Science, EarlyView.This study first identifies NOX2 as a differentially expressed gene related to oxidative damage in the apical and basal turns through single‐cell RNA sequencing. NOX2 gene knockout mitigates OHCs damage caused by neomycin and noise and enhances Nrf2 expression and nuclear translocation.
Meihao Qi +16 more
wiley +1 more source
Rapid B cell apoptosis induced by antigen receptor ligation does not require Fas (CD95/APO-1), the adaptor protein FADD/MORT1 or CrmA-sensitive caspases but is defective in both MRL-+/+ and MRL-lpr/lpr mice [PDF]
, 2000 Tsutomu Yoshida +5 more
openalex +1 more source
Rational Design of Inner Ear Drug Delivery Systems
Advanced Science, EarlyView.Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu +5 more
wiley +1 more source
Aven, a Novel Inhibitor of Caspase Activation, Binds Bcl-xL and Apaf-1 [PDF]
, 2000 B CHAU
openalex +1 more source
Rab39a binds caspase-1 and is required for caspase-1-dependent il-1{beta} secretion
, 2009 PUBLISHED PMID: 19833722 IL-1? is an important pro-inflammatory cytokine that is secreted by unconventional means in a caspase-1-dependent manner. Using a one-step immunoprecipitation approach to isolate endogenous caspase-1 from the monocytic THP1 cell line, we identified previously undescribed binding partners using mass spectrometry.
O'NEILL, LUKE ANTHONY JOHN, CREAGH, EMMA
openaire +2 more sources
Advanced Science, EarlyView.This study investigates hypoglycemia‐induced diabetic macrovascular endothelial dysfunction. It reveals that hypoglycemia triggers ZBP1‐dependent PANoptosis of endothelial cells, proinflammatory polarization of macrophages, and fibrosis of vascular smooth muscle cells (VSMCs) in diabetic mice.
Deyu Zuo +10 more
wiley +1 more source
MEK Kinase 1, a Substrate for DEVD-Directed Caspases, Is Involved in Genotoxin-Induced Apoptosis
, 1998 Christian Widmann +4 more
openalex +1 more source
FADD/MORT1 and Caspase-8 Are Recruited to TRAIL Receptors 1 and 2 and Are Essential for Apoptosis Mediated by TRAIL Receptor 2 [PDF]
, 2000 Martin R. Sprick +7 more
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Advanced Science, EarlyView.This study demonstrates that the transport of lactate to the mitochondria is of critical importance in determining the functions of macrophages by altering mitochondrial respiration. In macrophages, this lactate transport mechanism regulates glucose homeostasis by influencing the functions of insulin‐secreting cells in the pancreatic islets.
Lingling Chen +9 more
wiley +1 more source