Results 241 to 250 of about 24,063,457 (338)

The Role of Caspase-1 and Caspase-4 in Modulating Gingival Epithelial Cell Responses to <i>Aggregatibacter actinomycetemcomitans</i> Infection. [PDF]

Pathogens
Demirel KJ, Neves Guimaraes A, Demirel I.   +2 more
europepmc   +1 more source

IL-1β-converting enzyme (caspase-1) in intestinal inflammation [PDF]

, 2001
Britta Siegmund, Hans-Anton Lehr, Giamila Fantuzzi, Charles A. Dinarello   +3 more
openalex   +1 more source

Novel ATR/PARP1 Dual Inhibitors Demonstrate Synergistic Antitumor Efficacy in Triple‐Negative Breast Cancer Models

Advanced Science, EarlyView.
Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao, Jiawei Zhou, Chen‐Chen Wang, Zong‐Hao Wang, Nian‐Dong Mao, Meng‐Lan He, Peng‐Peng Zhang, Ping Huang, Guo‐Wei Ye, Yu‐Qing Zhang, Feng‐Hui Tang, Hang Zhang, Tian Xie, Xiang‐Yang Ye   +13 more
wiley   +1 more source

Dataset on potential biochemical activities of Cylo phe-Ala-Asp-Gly-based compounds as Caspase 1 inhibitor. [PDF]

Data Brief
Olujinmi FE, Ajaelu CJ, Akintelu SA, Oyebamiji AK.   +3 more
europepmc   +1 more source

Differential Expression of Apoptotic Protease-Activating Factor-1 and Caspase-3 Genes and Susceptibility to Apoptosis during Brain Development and after Traumatic Brain Injury [PDF]

, 2001
Alexander G. Yakovlev, Katsuya Ota, Geping Wang, Vilen Movsesyan, Weili Bao, Koichiro Yoshihara, Alan I. Faden   +6 more
openalex   +1 more source

Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides

Journal of Immunology, 2016
Hana M. Russo, Joseph K. Rathkey, A. Boyd-Tressler, Michael A. Katsnelson, Derek W. Abbott, G. Dubyak   +5 more
semanticscholar   +1 more source

Dopamine D1 Receptor Contributes to Glucocorticoid‐Associated Osteonecrosis of Femoral Head Protection Through the ATF3/CHOP Axis to Inhibit Osteoblastic Apoptosis

Advanced Science, EarlyView.
This work identifies a novel mechanism by which dopamine D1 receptor (DRD1) contributes to the pathogenesis of glucocorticoid (GC)‐associated osteonecrosis of the femoral head (ONFH) through the regulation of osteoblastic apoptosis, indicating that DRD1 serves as a critical mediator of the crosstalk between the nervous and skeletal systems.
Kai Zheng, Wenming Li, Tianhao Wang, Gaoran Ge, Wei Zhang, Yi Qin, Wenhao Li, Zebin Wu, Zhen Wang, Gang Rui, Yaozeng Xu, Dechun Geng   +11 more
wiley   +1 more source

Sodium butyrate alleviates spinal cord injury via inhibition of NLRP3/Caspase-1/GSDMD-mediated pyroptosis. [PDF]

Metab Brain Dis
Cui Y, Cen Q, Feng J, Wei J, Wang L, Chang C, Pang R, Wang J, Zhang A.   +8 more
europepmc   +1 more source

Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis

, 2000
Piera Pasinelli, Megan K. Houseweart, Robert H. Brown, Don W. Cleveland   +3 more
openalex   +1 more source

Interferon γ inhibits growth of human pancreatic carcinoma cells via caspase-1 dependent induction of apoptosis [PDF]

, 2001
Katharina Detjen, Katrin Farwig, Martina Welzel, Bertram Wiedenmann, Stefan Rosewicz   +4 more
openalex   +1 more source