Results 91 to 100 of about 532,079 (203)

Anchored FRET sensors detect local caspase activation prior to neuronal degeneration [PDF]

, 2011
BACKGROUND: Recent studies indicate local caspase activation in dendrites or axons during development and in neurodegenerative disorders such as Alzheimer's disease (AD).
Ricardo A Figueroa, Veronica Ramberg, Tom Gatsinzi, Malin Samuelsson, Mu Zhang, Kerstin Iverfeldt, Einar Hallberg   +6 more
core   +1 more source

Cholestane-3β,5α,6β-triol induces cancer cell death by activating GSDME-mediated pyroptosis

Frontiers in Pharmacology
BackgroundTrihydroxysterols and their analogues accumulate in several pathologies, including neurodegenerative diseases, cancers, and atherosclerosis.
Jiaxi Chen, Yuan He, Min Zhao, Zihan Liu, Zixin Su, Chuanzhou Li, Chuanzhou Li, Chen Yang, Chen Yang, Jieping Zhang, Shuichun Mao, Hua Han, Zhenyu Cai, Wen Zhang, Wen Zhang   +14 more
doaj   +1 more source

Brainiac Caspases: Beyond the Wall of Apoptosis [PDF]

, 2019
For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as regulators of apoptosis or inflammation to having a wider range of functions.
Alonso Bellido, Isabel María, Burguillos García, Miguel Ángel, Espinosa Oliva, Ana María, García Revilla, Juan   +3 more
core   +1 more source

Expression of Beclin-1 and Caspase-3 After the Myocardial Contusion in Rats With High and Low Stress Resistance

Фундаментальная и клиническая медицина
Aim. To evaluate the activity of autophagy and apoptosis in the myocardium of rats with differentstress resistance after the modeling of myocardial contusion.Materials and Methods. The study was performed on 106 white male rats weighing 250-300 g.
E. I. Klyuchnikova, O. V. Korpacheva, S. I. Mozgovoi, A. N. Zolotov, A. V. Kononov   +4 more
doaj   +1 more source

In Vitro Evaluation of Cytotoxic Effects of Nickel Oxide Nanoparticles on Human Neuroblastoma Cell Line (SH-SY5Y)

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2021
Background and Objectives: Despite the many applications of nickel oxide nanoparticles (Nio NPs) in industry and biomedicine, limited studies have been performed in the case of the cytotoxicity of these nanoparticles onnervous system yet.
Mozhdeh Hajimohammadjafar tehrania, Mahsa Ale-Ebrahim, Mojtaba Falahati, Shahram Zarabiyan   +3 more
doaj  

Biomimetic dual-crosslinked GelMA-SilMA hydrogel microneedle for delivering DSPE-PEG2K-TAT-modified quercetin liposomes to treat rheumatoid arthritis via the caspase-8/caspase-3/GSDME pathway

Journal of Nanobiotechnology
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovitis, whose pathogenesis remains unclear. Fibroblast-like synoviocytes (FLS) are central to the pathogenesis and progression of RA. This study aims to investigate the novel
Qingcong Zheng, Rongjie Lin, Rongsheng Chen, Weihong Xu   +3 more
doaj   +1 more source

High Dose C6 Ceramide-Induced Response in Embryonic Hippocampal Cells

Biomolecules
Ceramide is a critical molecule in both the physiology and pathology of the central nervous system. The most studied aspect is its effect on embryonic/stem cells. A salient question is whether low doses of ceramide induce neuronal differentiation without
Federico Fiorani, Martina Mandarano, Samuela Cataldi, Alessandra Mirarchi, Stefano Bruscoli, Francesco Ragonese, Bernard Fioretti, Toshihide Kobayashi, Nario Tomishige, Tommaso Beccari, Claudia Floridi, Cataldo Arcuri, Elisabetta Albi   +12 more
doaj   +1 more source

Caspase-9 swings both ways in the apoptosome

Molecular & Cellular Oncology, 2017
For nearly 2 decades, investigators have debated whether cysteinyl-aspartate-specific protease 9 (caspase-9) is activated within the apoptotic protease-activating factor 1 (Apaf-1) apoptosome through proximity-induced homodimerization or through ...
Chu-Chiao Wu, Shawn B. Bratton
doaj   +1 more source

Caspase-9 Activation and Caspase Cleavage of tau in the Alzheimer's Disease Brain

Neurobiology of Disease, 2002
Accumulating evidence supports a role for the activation of proteolytic enzymes, caspases, in the Alzheimer's disease (AD) brain. Neurons committed to apoptosis may do so through a mitochondrial pathway employing caspase-9 or through an alternative ...
Troy T. Rohn, Robert A. Rissman, Michael C. Davis, Young Eun Kim, Carl W. Cotman, Elizabeth Head   +5 more
doaj   +1 more source

Paeoniflorin improves cardiac function and decreases adverse postinfarction left ventricular remodeling in a rat model of acute myocardial infarction

Drug Design, Development and Therapy, 2018
Hengwen Chen,* Yan Dong,* Xuanhui He, Jun Li, Jie Wang Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China *These authors contributed equally to this work Background: Paeoniflorin (PF) is the active component of ...
Chen H, Dong Y, He X, Li J, Wang J
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