Results 121 to 130 of about 530,883 (357)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Pramanicin analog induces apoptosis in human colon cancer cells: critical roles for Bcl-2, Bim, and p38 MAPK signaling [PDF]

, 2013
Pramanicin (PMC) is an antifungal agent that was previously demonstrated to exhibit antiangiogenic and anticancer properties in a few in vitro studies. We initially screened a number of PMC analogs for their cytotoxic effects on HCT116 human colon cancer
Başağa, Hüveyda, Bodur, Çağrı, Harrison, Paul, Isimjan, Tayirjan T., Karslı, Gizem, Kütük, Özgür   +5 more
core   +1 more source

In Vitro Evaluation of Cytotoxic Effects of Nickel Oxide Nanoparticles on Human Neuroblastoma Cell Line (SH-SY5Y)

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2021
Background and Objectives: Despite the many applications of nickel oxide nanoparticles (Nio NPs) in industry and biomedicine, limited studies have been performed in the case of the cytotoxicity of these nanoparticles onnervous system yet.
Mozhdeh Hajimohammadjafar tehrania, Mahsa Ale-Ebrahim, Mojtaba Falahati, Shahram Zarabiyan   +3 more
doaj  

Apoptose na maturação placentária de vacas em diferentes estágios de gestação: evidenciação imuno-histoquímica e bioquímica

Pesquisa Veterinária Brasileira, 2011
Apoptose tem um papel importante na manutenção da homeostase placentária, e o desequilíbrio desse processo pode comprometer a gestação. O objetivo do presente estudo foi avaliar a ocorrencia de apoptose em amostras de placenta de vacas em diferentes ...
Karina K.O.L. Meça, Helen L Del Puerto, Luciana V. Rodrigues, Milene A. Rachid, Nubia B. Pereira, Márcia G.L. Cândido, Anilton C. Vasconcelos   +6 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Both the Caspase CSP-1 and a Caspase-Independent Pathway Promote Programmed Cell Death in Parallel to the Canonical Pathway for Apoptosis in Caenorhabditis elegans [PDF]

, 2012
Caspases are cysteine proteases that can drive apoptosis in metazoans and have critical functions in the elimination of cells during development, the maintenance of tissue homeostasis, and responses to cellular damage. Although a growing body of research
A Cauwels, A Degterev, A Gartner, A Raj, AH Wyllie, AM Chinnaiyan, B Conradt, B Pinan-Lucarre, B Schumacher, BT Hyman, D Xue, D Xue, Daniel P. Denning, DJ Dwyer, DJ Hoeppner, DP Denning, DT Harris, E Arama, E Pourkarimi, EC Andersen, EH Cheng, EM Hedgecock, ES Blum, F Chen, F Madeo, F Simmer, H. Robert Horvitz, HC Chang, Hermann Steller, HM Ellis, HT Schwartz, J Yuan, J Yuan, JE Sulston, JE Sulston, JF Kerr, JM Kinchen, JY Yuan, K Xu, M Darland-Ransom, MC Abraham, MC Abraham, MO Hengartner, MO Hengartner, NA Thornberry, PW Reddien, RA Lockshin, RE Ellis, S Brenner, S Harbinder, S Qi, S Seshagiri, S Shaham, S Shaham, S Shaham, SA Susin, T Hirose, TL Gumienny, V Venegas, VA Fadok, Victoria Hatch, X Geng, X Geng, X Wang, X Yang, Z Zhou   +65 more
core   +4 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Intertwined Functions of Separase and Caspase in Cell Division and Programmed Cell Death. [PDF]

, 2020
Timely sister chromatid separation, promoted by separase, is essential for faithful chromosome segregation. Separase is a member of the CD clan of cysteine proteases, which also includes the pro-apoptotic enzymes known as caspases.
Jeong, Pan Young, Joshi, Pradeep M, Kumar, Ashish, Rothman, Joel H   +3 more
core   +1 more source

Cardiac Specific Overexpression of Mitochondrial Omi/HtrA2 Induces Myocardial Apoptosis and Cardiac Dysfunction. [PDF]

, 2016
Myocardial apoptosis is a significant problem underlying ischemic heart disease. We previously reported significantly elevated expression of cytoplasmic Omi/HtrA2, triggers cardiomyocytes apoptosis.
Jiao, Kun, Lau, Wayne Bond, Liu, Huirong, Liu, Xin, Ma, Lu, Ma, Xinliang, Shang, Jianyu, Wang, Ke, Wang, Wen, Wang, Xiaoliang, Yuan, Yuexing, Zuo, Lin   +11 more
core   +2 more sources

The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation

eLife
Caspase (CASP) is a family of proteases involved in cleavage and activation of gasdermin, the executor of pyroptosis. In humans, CASP3 and CASP7 recognize the same consensus motif DxxD, which is present in gasdermin E (GSDME).
Hang Xu, Zihao Yuan, Kunpeng Qin, Shuai Jiang, Li Sun   +4 more
doaj   +1 more source