Results 161 to 170 of about 532,079 (203)

Modulation of SIRT-1, NF-κB/TNF-α/IL-6, and ERK/Caspase-3 by Lutein Mitigates Methotrexate-Induced Hepatotoxicity. [PDF]

Pharmaceuticals (Basel)
Abdelwahab AM, Habib HA, Darwish MA, Bin Jardan YA, Heeba GH.   +4 more
europepmc   +1 more source

EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase-3 and Aifm1 Splicing Pathways. [PDF]

Adv Sci (Weinh)
Chen L, Li Y, Yu Y, Cai M, Li H, Huang M, Yang G, Guo J, Wang H, Song Z, Shen W, Jiang H, Wu H.   +12 more
europepmc   +1 more source

A novel sono-activatable nanoreactor induces precision intratumoral juglone generation and caspase 3/GSDME-mediated pyroptosis for treatment of bladder cancer. [PDF]

J Nanobiotechnology
Zhang Y, Yang E, Zhang X, Shi Y, Fan G, Wang Y, Tian J, Wang H, Dong Z, Wang Y, Cheng L, Zhao Z, Zhang Y, Wang B, Wang Z.   +14 more
europepmc   +1 more source

Pyroptosis Mediated by ROS/Caspase-3/GSDME Pathway in Aspergillus fumigatus-Induced Fungal Keratitis. [PDF]

Invest Ophthalmol Vis Sci
Kan J, Song S, Liu M, Xu Q, Lee J, Sun J, Xue S, Sun X, Che C.   +8 more
europepmc   +1 more source

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Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation

Nature Medicine, 2000
Dysregulation of apoptosis contributes to the pathogenesis of many human diseases. As effectors of the apoptotic machinery, caspases are considered potential therapeutic targets. Using an established in vivo model of Fas-mediated apoptosis, we demonstrate here that elimination of certain caspases was compensated in vivo by the activation of other ...
T S, Zheng, S, Hunot, K, Kuida, T, Momoi, A, Srinivasan, D W, Nicholson, Y, Lazebnik, R A, Flavell   +7 more
openaire   +2 more sources

Caspase-3 Activators as Anticancer Agents

Current Protein & Peptide Science, 2023
Background: The cancer is still a major cause of death worldwide. Among different targets to design anticancer agents, caspase-3 is an important target as its cleavage and activation lead to apoptosis and finally, cancer cell death. Apart from some naturally occurring molecules, many small molecules have been reported as caspase-3 activators ...
Nitin Srivastava, Anil Kumar Saxena
openaire   +2 more sources

Novel zebrafish caspase-3 substrates

Biochemical and Biophysical Research Communications, 2007
The zebrafish model has been widely used to investigate numerous signaling pathways in vertebrates, including programmed cell death. Although several zebrafish proteins homologous to mammalian caspases have been identified, our understanding of these zebrafish caspases is still limited.
C Alexander, Valencia, Christian, Bailey, Rihe, Liu   +2 more
openaire   +2 more sources