Results 191 to 200 of about 331,832 (268)

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

Protection against post-resuscitation renal injury by Artesunate via inhibition of caspase-3/Gasdermin E -mediated pyroptosis. [PDF]

Resusc Plus
Wang Q, Shen P, Wu W, Zhu J, Xu J.
europepmc   +1 more source

Apoptosis and caspase-3 activity in isolated fetal rat lung cells, human A549 cells and rat periodontal ligament fibroblasts following exposure to cigarette smoke extract

, 2012
Asra Ahmed
openalex   +1 more source

The impact of Keap1/Nrf2, P38MAPK/NF-κB and Bax/Bcl2/caspase-3 signaling pathways in the protective effects of berberine against methotrexate-induced nephrotoxicity

, 2018
Emad H. M. Hassanein, Abdel‐Gawad S. Shalkami, Marwa M. Khalaf, Wafaa R. Mohamed, Ramadan A.M. Hemeida   +4 more
openalex   +1 more source

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

Activation of human endogenous retroviruses by Sox proteins induces cell apoptosis via the caspase-3 pathway. [PDF]

Front Microbiol
Hossain MJ, Monde N, Sasaki H, Nyame P, Amesimeku WAO, Terasawa H, Matsumura S, Matsui T, Tsutsuki H, Maeda Y, Sawa T, Monde K.   +11 more
europepmc   +1 more source

<p>MicroRNA-34a suppresses aggressiveness of hepatocellular carcinoma by modulating <em>E2F1</em>, <em>E2F3</em>, and Caspase-3</p>

, 2019
Rui Han, Xinyi Chen, Ya Li, Shunjia Zhang, Ruibai Li, Lingeng Lu   +5 more
openalex   +2 more sources

Ultrasound‐Boosted Liposomal Prodrug Overcomes Age‐Associated Biodistribution Disparity in Pediatric Solid Tumor Therapy

Advanced Science, EarlyView.
The age‐associated disparity of nanocarrier biodistribution limits the nanotherapeutics of childhood solid tumors. This study developed an ultrasound‐activated liposomal prodrug (CSCPTL) to overcome the age‐associated disparity of off‐target distribution.
Danfei Chen, Junjun Xu, Jian Chen, Jue Hu, Xiaobo Xuan, Haifang Cai, Mingdong Yang, Zhuxian Zhou, Guowei Wang   +8 more
wiley   +1 more source

Modulation of SIRT-1, NF-κB/TNF-α/IL-6, and ERK/Caspase-3 by Lutein Mitigates Methotrexate-Induced Hepatotoxicity. [PDF]

Pharmaceuticals (Basel)
Abdelwahab AM, Habib HA, Darwish MA, Bin Jardan YA, Heeba GH.   +4 more
europepmc   +1 more source

Ethanol inhibits methionine adenosyltransferase II activity and S-adenosylmethionine biosynthesis and enhances caspase-3-dependent cell death in T lymphocytes: relevance to alcohol-induced immunosuppression

, 2007
Prachi Hote, Rashmita Sahoo, Tanvi S. Jani, Smita Ghare, Theresa Chen, Swati Joshi‐Barve, Craig J. McClain, Shirish Barve   +7 more
openalex   +1 more source