Results 271 to 280 of about 530,883 (357)

ADAR1 as a Placental Innate Immune Rheostat Sustaining the Homeostatic Balance of Intrinsic Interferon Response at the Maternal‐Fetal Interface

Advanced Science, EarlyView.
This study reveals that ADAR1, an RNA‐editing enzyme, fine‐tunes immune responses in the placenta by preventing the accumulation of immunogenic double‐stranded RNAs (dsRNAs) from interferon‐stimulated genes. The loss of ADAR1 in the placenta leads to excessive interferon signaling restricted to the junctional zone, disrupting placental development and ...
Xiaogang Chen, Xiangchao Xu, Jiahao Chen, Huiru Zhang, Wanshan Zheng, Wenzhe Yu, Xiaoqian Hu, Bin Cao   +7 more
wiley   +1 more source

Lipin3 deficiency aggravates cisplatin induced acute kidney injury via activating Sirt1-p21-Caspase 3-GSDME pyroptosis pathway. [PDF]

Int J Biol Sci
Liu YX, Huang H, Wang F, Zhao MF, Jin JY, Dong Y, Wang Q, Fan LL, Xiang R.   +8 more
europepmc   +1 more source

Involvement of caspase-3 activation and p53 in arsenic trioxide induced apoptosis in human gastric cancer cells

, 2000
Jiang Xh, SK Lam, SH Jiang, ST Yuen, CH Cho, KC Lai, Bcy Wong   +6 more
openalex   +1 more source

A Redox‐Active and Electroactive Hydrogel Enabled by an Integrated PEDOT@PMOF Nanofiller for Post‐Infarct Myocardial Repair

Advanced Science, EarlyView.
An integrated nanoparticle PEDOT@PMOF is constructed as a redox‐active nanozyme and electroactive nanofiller in a cell‐affinity hydrogel platform for acute MI treatment. It is demonstrated that MOF‐based nanozymes have good catalytic ability, and the incorporation of PEDOT increases the conductivity.
Shuyi He, Linyu Long, Wenqi Liu, Zhicun Wang, Xiaofeng Wu, Li Yang, Yunbing Wang   +6 more
wiley   +1 more source

Air-Exposure- and Reoxygenation-Stimulated Expressions of Caspase-3 and Induction of Apoptosis in the Central Nervous System of the Crab Erimacrus isenbeckii. [PDF]

Cells
Kotsyuba E, Dyachuk V.
europepmc   +1 more source

P21, Bax and Caspase-3 participate in the propagating mechanism of apoptosis in the human gastric epithelial cells

, 2000
Kenji Noguchi, Katsuaki Kato, Ging Yang, Tatsuhiko Suzuki, Yuji Kubota, Naohiro Dairaku, Keisuke Oikawa, Yutaka Konno, Hitoshi Sekine, Shuichi Ohara, Takayoshi Toyota, Tooru Shimosegawa   +11 more
openalex   +1 more source

Restoring NK Cell Cytotoxicity Post‐Cryopreservation via Synthetic Cells

Advanced Science, EarlyView.
In this study, it is shown that 1‐day co‐culture with activated T cells or IL‐2‐presenting synthetic cells significantly enhances NK cell motility and cytotoxicity in 2D and 3D. Notably, synthetic cells restore the impaired cytotoxic function of cryopreserved NK and CAR‐NK cells in 3D.
Xiangda Zhou, Sijia Zhang, Wenjuan Yang, Susanne Gonder, Zeinab Sadjadi, Nils Piernitzki, Alina Moter, Shulagna Sharma, Anne Largeot, Nadja Küchler, Lea Kaschek, Gertrud Schäfer, Eva C. Schwarz, Hermann Eichler, Evelyn Ullrich, Heiko Rieger, Oskar Staufer, Jérôme Paggetti, Etienne Moussay, Markus Hoth, Bin Qu   +20 more
wiley   +1 more source

Metamizole limits proliferation in chronic myeloid leukemia cells and triggers apoptosis via the bax/bcl-2/caspase-3 cascade. [PDF]

Med Oncol
Maytalman E, Nemutlu Samur D.
europepmc   +1 more source

Activation of caspase-3 by cysteamine: Possible mechanism of the CDK inhibitor p21 cleavage in duodenal ulceration

, 2000
Tetyana Khomenko, Sándor Szabó, Masashi Yoshida, Xiaoming Deng, Warner H. Florsheim, Hiroko Matsumoto   +5 more
openalex   +1 more source

From Bench to Bedside: Emerging Paradigms in CAR‐T Cell Therapy for Solid Malignancies

Advanced Science, EarlyView.
This review discusses emerging paradigms in CAR‐T cell therapy for solid tumors, emphasizing strategies to overcome therapeutic barriers through synthetic biology, immune engineering, and combinatorial approaches. It highlights advancements in logic gating, modulation of the immune microenvironment, and innovative cell designs, providing valuable ...
Yang Chen, Ran Ren, Lirong Yan, Yu Zhou, Ruokai Sun, Huicong Song, Hongfei Yan, Yongsheng Li   +7 more
wiley   +1 more source