Results 281 to 290 of about 390,973 (308)

Immunoreactivity to caspase-3, caspase-7, caspase-8, and caspase-9 forms is frequently lost in human prostate tumors

Human Pathology, 2012
Caspases are essential initiators and executioners of apoptosis. Changes in their expression may contribute to the development of proliferative disorders such as cancer, by altering the death-proliferation homeostatic balance. The aim of this work was to analyze the expression of a broad panel of caspases at the epithelial level in human prostate ...
Gonzalo, Rodríguez-Berriguete, Laura, Galvis, Benito, Fraile, Fermín R, de Bethencourt, Pilar, Martínez-Onsurbe, Gabriel, Olmedilla, Ricardo, Paniagua, Mar, Royuela   +7 more
openaire   +2 more sources

A Crucial Role of Caspase 3 and Caspase 8 in Paclitaxel-Induced Apoptosis

Molecular Cell Biology Research Communications, 1999
The anticancer drug paclitaxel is well known as an inhibitor of microtubule depolymerization, resulting in mitosis arrest. We investigated the mechanism underlying antitumor effects of paclitaxel on the lung adenocarcinoma cell line LC-2-AD. Less than 10 microg/ml paclitaxel induced mitosis arrest upon LC-2-AD, followed by apoptosis, but more than 30 ...
H, Oyaizu, Y, Adachi, S, Taketani, R, Tokunaga, S, Fukuhara, S, Ikehara   +5 more
openaire   +2 more sources

The effect of uremia and hemodialysis on caspase-1 and caspase-3 activity in neutrophils

Journal of Nephrology, 2010
Abstract Background: Neutrophils in uremia maintain chronic inflammation, which contributes to malnutrition and immunity disorders. The influence of hemodialysis on the life span of neutrophils is unclear, although many authors postulate its apoptotic effect. Erythropoietin (EPO) is an antiapoptotic factor for various cells.
Irmina, Korzeniewska-Dyl, Krzysztof, Wróblewski, Ewa, Majewska, Dariusz, Moczulski   +3 more
openaire   +2 more sources

Prognostic Significance of the Immunohistochemical Staining of Cleaved Caspase-3, an Activated Form of Caspase-3, in Gliomas

Clinical Cancer Research, 2007
Abstract Purpose: Gliomas are common tumors of the central nervous system, and the majority of patients with gliomas have a poor prognosis. The prediction of prognosis is very important in selecting treatment. In the present study, we retrospectively examined the immunohistochemical staining of cleaved caspase-3 (CC3), an activated form ...
Tatsuya, Kobayashi, Junya, Masumoto, Tsuyoshi, Tada, Tetsuo, Nomiyama, Kazuhiro, Hongo, Jun, Nakayama   +5 more
openaire   +2 more sources

Quantification of Active Caspase-3 and Active Caspase-8 in Microglia Cells

2013
During microglia activation the levels of active caspase-3, caspase-7 and caspase-8 are increased, which leads to the transcription of proinflammatory cytokines and factors. As such, the induction of caspase activity in microglia can be used as a marker for activation.
openaire   +2 more sources

Caspase-3 and Caspase-7

2013
Tom Vanden Berghe, Kristof Kersse, Peter Vandenabeele   +2 more
openaire   +1 more source

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

Cell, 2020
Min Zheng, Rajendra Karki
exaly  

Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis

Immunity, 2020
Bart Tummers, Luigi Mari, Bradlee L Heckmann   +2 more
exaly  

ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P

Cell, 2018
Ricard Garcia-Carbonell, Shinichiro Yamachika, Peng Zhao   +2 more
exaly  

Identification of a new caspase homologue: caspase-14

Cell Death and Differentiation, 1998
Marc Van De Craen, Geert Van Loo, W Declercq   +2 more
exaly