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Caspase‐3: Structure, function, and biotechnological aspects

Biotechnology and applied biochemistry, 2021
Caspase‐3, a cysteine‐aspartic acid protease, has recently attracted much attention because of its incredible roles in tissue differentiation, regeneration, and neural development. This enzyme is a key zymogen in cell apoptosis and is not activated until
M. Asadi   +6 more
semanticscholar   +1 more source

Caspase‐3: A primary target for natural and synthetic compounds for cancer therapy

Chemical Biology and Drug Design, 2021
Caspases, a group of protease enzymes (cysteine proteases), exist as inactive zymogens in the cells and execute apoptosis (programmed cell death). Caspase‐3, an executioner caspase, plays an imperative role in apoptosis and becomes a primary target for ...
P. Yadav   +3 more
semanticscholar   +1 more source

Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8. [PDF]

open access: yesJournal of Molecular Biology, 2018
Canonical inflammasomes are multiprotein complexes that can activate both caspase-1 and caspase-8. Caspase-1 drives rapid lysis of cells by pyroptosis and maturation of interleukin (IL)-1β and IL-18. In caspase-1-deficient cells, inflammasome formation still leads to caspase-3 activation and slower apoptotic death, dependent on caspase-8 as an apical ...
V. Sagulenko   +4 more
semanticscholar   +5 more sources

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