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Diagnostics, 2021 (1) Background: The estimation of the post mortem interval (PMI) is a challenge for forensic pathologists because data emerging from methods commonly applied are not always conclusive, since several conditions exist that may affect the reliability of ...
Cristina Mondello +10 more
doaj +1 more source
Emerging roles of caspase-3 in apoptosis [PDF]
Cell Death & Differentiation, 1999 Caspases are crucial mediators of programmed cell death (apoptosis). Among them, caspase-3 is a frequently activated death protease, catalyzing the specific cleavage of many key cellular proteins. However, the specific requirements of this (or any other) caspase in apoptosis have remained largely unknown until now. Pathways to caspase-3 activation have
Alan G. Porter, Reiner U. Jänicke
openaire +3 more sources
Salmonella Pathogenesis and Processing of Secreted Effectors by Caspase-3 [PDF]
, 2010 The enteric pathogen Salmonella enterica serovar Typhimurium causes food poisoning resulting in gastroenteritis. The S. Typhimurium effector Salmonella invasion protein A (SipA) promotes gastroenteritis by functional motifs that trigger either mechanisms
A. Maldonado-Contreras +28 more
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An improved superoxide-generating nanodevice for oxidative stress studies in cultured cells
Biotechnology Reports, 2015 The effects of reactive oxygen species on cells have attracted great attention from both physiological and pathological aspects. Superoxide (O2−) is the primary reactive oxygen species formed in animals.
Minoru Tamura +5 more
doaj +1 more source
Caspase-3 joins the p53 interactome [PDF]
Cancer Biology & Therapy, 2011 Commentary to: Wild-type and mutant p53 proteins interact with mitochondrial caspase-3Amanda K. Frank, E.
Klaus Roemer, Kristina Heyne
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Apoptotic gene expression in neuropathic pain [PDF]
, 2008 Pain initiated or caused by a primary lesion or dysfunction in the nervous system is defined as neuropathic pain. It results from direct injury to nerves in the peripheral or central nervous system and is associated with several clinical symptoms ...
Annalucia Migliozzi +6 more
core +2 more sources
Neurobiology of Disease, 2006 Neonatal hypoxia–ischemia (H–I) is a common cause of perinatal morbidity and mortality leading to prominent activation of caspase-3 in the brain. Previous studies have shown that acute inhibition of caspase-3 can protect against neonatal H–I in rats.
Tim West +2 more
doaj +1 more source
Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates pro-apoptotic signaling involving caspase 9 and mitochondrial release of endonuclease G [PDF]
, 2005 BACKGROUND: In type 2 diabetes, free fatty acids (FFA) accumulate in microvascular cells, but the phenotypic consequences of FFA accumulation in the microvasculature are incompletely understood. Here we investigated whether saturated FFA induce apoptosis
Mishra, Rangnath, Simonson, Michael S
core +3 more sources
The Role of Caspases in Melanoma Pathogenesis
Current Issues in Molecular BiologyMelanoma (malignant melanoma, MM) is an aggressive malignant skin cancer with an increasing incidence rate. The complete pathogenesis of MM in not clear.
Agnieszka Szmurło +7 more
doaj +1 more source
Physiological Reports, 2019 Excessive cellular accumulation or exposure to lipids such as long‐chain acylcarnitines (LCACs), ceramides, and others is implicated in cell stress and inflammation.
Colin S. McCoin +7 more
doaj +1 more source