Results 31 to 40 of about 548,432 (354)
Salmonella Pathogenesis and Processing of Secreted Effectors by Caspase-3 [PDF]
, 2010 The enteric pathogen Salmonella enterica serovar Typhimurium causes food poisoning resulting in gastroenteritis. The S. Typhimurium effector Salmonella invasion protein A (SipA) promotes gastroenteritis by functional motifs that trigger either mechanisms
A. Maldonado-Contreras +28 more
core +1 more source
Frontiers in Pharmacology, 2022 Purpose: The incidence of uric acid (UA)-induced kidney injury is increasing owing to the high incidence of hyperuricemia in recent years. The flower of Abelmoschus manihot (Linneus) Medik is a traditional Chinese medicinal herb widely used in the ...
Zhihui Ding +14 more
doaj +1 more source
Molecular Dynamics Studies of Caspase-3 [PDF]
Biophysical Journal, 2003 Caspase-3 is a fundamental target for pharmaceutical interventions against a variety of diseases involving disregulated apoptosis. The enzyme is active as a dimer with two symmetry-related active sites, each featuring a Cys-His catalytic dyad and a selectivity loop, which recognizes the characteristic DEVD pattern of the substrate.
Sulpizi, M. +2 more
openaire +2 more sources
An improved superoxide-generating nanodevice for oxidative stress studies in cultured cells
Biotechnology Reports, 2015 The effects of reactive oxygen species on cells have attracted great attention from both physiological and pathological aspects. Superoxide (O2−) is the primary reactive oxygen species formed in animals.
Minoru Tamura +5 more
doaj +1 more source
Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation. [PDF]
, 2019 Gasdermin E (GSDME/DFNA5) cleavage by caspase-3 liberates the GSDME-N domain, which mediates pyroptosis by forming pores in the plasma membrane.
Alnemri, Emad S. +5 more
core +3 more sources
Controlling TRAIL-mediated caspase-3 activation [PDF]
Leukemia, 2004 This commentary is addressed at the paper by Dr Jie and his co-workers in the current issue of Leukemia (‘Differential involvement of Bax and Bak in TRAIL-mediated apoptosis of leukemic T cells’). In this paper, the authors show the preferential use of Bax over Bak for the induction of mitochondrial apoptotic events in leukemic cell exposed to TRAIL 1.
Micheau, Olivier, Mérino, Delphine
openaire +2 more sources
Kaposi's sarcoma herpesvirus microRNAs target caspase 3 and regulate apoptosis.
PLoS Pathogens, 2011 Kaposi's sarcoma herpesvirus (KSHV) encodes a cluster of twelve micro (mi)RNAs, which are abundantly expressed during both latent and lytic infection.
Guillaume Suffert +13 more
doaj +1 more source
Characterization of Canine Caspase-3
Journal of Veterinary Medical Science, 2004 The canine caspase-3 gene was cloned and sequenced. The canine caspase-3 cDNA clone was 1473 base pairs in length and encoded 277 amino acids. The predicted amino acid sequence showed 88.4%, 88.0%, 85.9%, 65.9% and 60.6% homology with that of human, pig, mouse, chicken and zebra fish caspase-3, respectively.
Junichi, Sano +3 more
openaire +3 more sources
Aktifitas Caspase 3 sebagai Indikator Apoptosis pada Sel Kanker Ovarium
Indonesian Journal of Cancer, 2007 Kematian yang diakibatkan oleh kanker ovarium masih tetap tinggi meskipun sudah dengan penanganan yang agresif. Pemberian kemoterapi merupakan bagian penting selain tindakan operasi di dalam pengobatan kanker ovarium.
Bambang Dwipoyono
doaj +1 more source
Visualising apoptosis in live zebrafish using fluorescence lifetime imaging with optical projection tomography to map FRET biosensor activity in space and time [PDF]
, 2015 Fluorescence lifetime imaging (FLIM) combined with optical projection tomography (OPT) has the potential to map Förster resonant energy transfer (FRET) readouts in space and time in intact transparent or near transparent live organisms such as zebrafish ...
Alexandrov, Y +13 more
core +2 more sources