Results 11 to 20 of about 390,973 (308)
Elevated caspase 3 expression correlates with severe inflammation in Crohn’s disease [PDF]
European Journal of HistochemistryCaspase 3 is a key executioner of apoptotic cell death and contributes to intestinal epithelial homeodynamics. Apoptotic dysregulation has been implicated in Crohn’s disease, yet data on caspase 3 expression across disease activity states remain limited.
Nafie Sedju +2 more
doaj +2 more sources
Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival [PDF]
Apoptosis, 2016 Impaired apoptosis is one of the hallmarks of cancer. Caspase-3 and -8 are key regulators of the apoptotic response and have been shown to interact with the calpain family, a group of cysteine proteases, during tumorigenesis. The current study sought to investigate the prognostic potential of caspase-3 and -8 in breast cancer, as well as the prognostic
Pu, Xuan +6 more
openaire +5 more sources
Executioner caspase-3 and caspase-7 are functionally distinct proteases [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2008 Members of the caspase family of cysteine proteases play central roles in coordinating the stereotypical events that occur during apoptosis. Because the major executioner caspases, caspase-3 and caspase-7, exhibit almost indistinguishable activity toward certain synthetic peptide substrates, this has led to the widespread view that these ...
John G Walsh +2 more
exaly +3 more sources
Emerging roles of caspase-3 in apoptosis [PDF]
Cell Death and Differentiation, 1999 Caspases are crucial mediators of programmed cell death (apoptosis). Among them, caspase-3 is a frequently activated death protease, catalyzing the specific cleavage of many key cellular proteins. However, the specific requirements of this (or any other) caspase in apoptosis have remained largely unknown until now. Pathways to caspase-3 activation have
Reiner U Janicke, Janicke Reiner U
exaly +3 more sources
Metalloporphyrins inactivate caspase‐3 and ‐8 [PDF]
The FASEB Journal, 2005 ABSTRACT Activation of caspases represents one of the earliest biochemical indicators for apoptotic cell death. Therefore, measurement of caspase activity is a widely used and generally accepted method to determine apoptosis in a wide range of in vivo and in vitro settings.
Blumenthal, Signe B. +8 more
openaire +5 more sources
Caspase-3 Colorimetric Assay [PDF]
BioTechniques, 2002 Lizhi Zeng, Larry D. Smith
doaj +3 more sources
Diagnostics, 2021 Ovarian cancer remains a major diagnostic and therapeutic problem in modern gynecological oncology. For this reason, research which focuses on the search for new diagnostic markers and the assessment of their possible usefulness in clinical practice is ...
Aleksandra Mielczarek-Palacz +2 more
doaj +1 more source
Roles of apoptosis and autophagy in natural rabies infections
Veterinární Medicína, 2022 The aim of this study was to investigate the activity of apoptosis and autophagy in animals (cows, horses, donkeys, dogs and cats) naturally infected with rabies by using immunohistochemistry, immunofluorescence, and qPCR.
M Ozkaraca +3 more
doaj +1 more source
The calpain, caspase 12, caspase 3 cascade leading to apoptosis is altered in F508del-CFTR expressing cells. [PDF]
PLoS ONE, 2009 In cystic fibrosis (CF), the most frequent mutant variant of the cystic fibrosis transmembrane conductance regulator (CFTR), F508del-CFTR protein, is misfolded and retained in the endoplasmic reticulum (ER). We previously showed that the unfolded protein
Mathieu Kerbiriou +4 more
doaj +1 more source
Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy [PDF]
Journal of the American Society of Nephrology, 2016 Glomerular apoptosis may contribute to diabetic nephropathy (dNP), but the pathophysiologic relevance of this process remains obscure. Here, we administered two partially disjunct polycaspase inhibitors in 8-week-old diabetic (db/db) mice: M-920 (inhibiting caspase-1, -3, -4, -5, -6, -7, and -8) and CIX (inhibiting caspase-3, -6, -7, -8, and -10 ...
Khurrum, Shahzad +11 more
openaire +2 more sources