Results 11 to 20 of about 548,432 (354)

Huntingtin inhibits caspase‐3 activation [PDF]

The EMBO Journal, 2006
Huntington's disease results from a mutation in the HD gene encoding for the protein huntingtin. The function of huntingtin, although beginning to be elucidated, remains largely unclear. To probe the prosurvival function of huntingtin, we modulate levels of wild-type huntingtin in a number of cellular and in vivo models.
Yu, Zhang, Blair R, Leavitt, Jeremy M, van Raamsdonk, Ioannis, Dragatsis, Dan, Goldowitz, Marcy E, MacDonald, Michael R, Hayden, Robert M, Friedlander   +7 more
openaire   +2 more sources

Astaxanthin effect on apoptotic biomarkers in methotrexate-induced liver injury

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022
Methotrexate is used in the treatment of cancer, psoriasis, rheumatoid arthritis and several other disorders. It has a hepatotoxic potential side effect. Patients who have no access to alternative medications face a serious   challenge as a result.
Sarah Saad Hamdan, Yassir Mustafa Kamal, Huda Jaber Waheed   +2 more
doaj   +1 more source

A non-apoptotic role for caspase-9 in muscle differentiation [PDF]

, 2008
Caspases, a family of cysteine proteases most often investigated for their roles in apoptosis, have also been demonstrated to have functions that are vital for the efficient execution of cell differentiation.
Fearnhead, Howard O, Howley, Breege A, McMahon, Jill M, Mohr, Andrea, Murray, Thomas VA, Ritter, Thomas, Stanley, Alanna, Zwacka, Ralf   +7 more
core   +1 more source

Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy [PDF]

Journal of the American Society of Nephrology, 2016
Glomerular apoptosis may contribute to diabetic nephropathy (dNP), but the pathophysiologic relevance of this process remains obscure. Here, we administered two partially disjunct polycaspase inhibitors in 8-week-old diabetic (db/db) mice: M-920 (inhibiting caspase-1, -3, -4, -5, -6, -7, and -8) and CIX (inhibiting caspase-3, -6, -7, -8, and -10 ...
Khurrum, Shahzad, Fabian, Bock, Moh'd Mohanad, Al-Dabet, Ihsan, Gadi, Shrey, Kohli, Sumra, Nazir, Sanchita, Ghosh, Satish, Ranjan, Hongjie, Wang, Thati, Madhusudhan, Peter P, Nawroth, Berend, Isermann   +11 more
openaire   +2 more sources

Uterine Endoplasmic Reticulum Stress and Its Unfolded Protein Response May Regulate Caspase 3 Activation in the Pregnant Mouse Uterus [PDF]

, 2013
We have previously proposed that uterine caspase-3 may modulate uterine contractility in a gestationally regulated fashion. The objective of this study was to determine the mechanism by which uterine caspase-3 is activated and consequently controlled in ...
Condon, Jennifer C., Jeyasuria, Pancharatnam, Kyathanahalli, Chandrashekara, Lydon, John P., Subedi, Kalpana, Suresh, Arvind   +5 more
core   +3 more sources

Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis [PDF]

BMC Cell Biology, 2013
AbstractBackgroundApoptosis is a form of programmed cell death that is regulated by the Bcl-2 family and caspase family of proteins. The caspase cascade responsible for executing cell death following cytochromecrelease is well described; however the distinct roles of caspases-9, -3 and -7 during this process are not completely defined.ResultsHere we ...
Brentnall, Matthew, Rodriguez-Menocal, Luis, De Guevara, Rebeka, Cepero, Enrique, Boise, Lawrence H   +4 more
openaire   +2 more sources

MDA-MB-231 cell apoptosis in vitro induced by dihydromyricetin

浙江大学学报. 农业与生命科学版, 2012
To investigate the effect of dihydromyricetin (DMY) induction on MDA-MB-231 cell apoptosis and its mechanism, the changes of cell morphological characteristics were observed under inverted microscope.
ZHOU Fang-zhen, ZHANG Xiao-yuan, SUN Fen-yong, GUO Yong   +3 more
doaj   +1 more source

Impact of L-carnitine and selenium treatment on testicular apoptosis in rats exposed to 2.45 GHz microwave energy [PDF]

, 2015
Objective: It has been suggested that electromagnetic radiation (EMR) by wireless devices (2.45 GHz) induces testicular apoptosis. We investigated if supplemental selenium (Se) and L-carnitine may reduce this adverse effect.
Comlekci, S., Gumral, N., Karahan, N., Ozguner, M.F., Saygin, M., Çalişkan, Sadettin   +5 more
core   +1 more source

Altered of apoptotic markers of both extrinsic and intrinsic pathways induced by hepatitis C virus infection in peripheral blood mononuclear cells

Virology Journal, 2012
Background Chronic hepatitis C (CHC) has emerged as a leading cause of cirrhosis in the U.S. and across the world. To understand the role of apoptotic pathways in hepatitis C virus (HCV) infection, we studied the mRNA and protein expression patterns of ...
Albertoni Guilherme, Arnoni Carine Prisco, Latini Flávia Roche Moreira, Andrade Sheila Siqueira, Araújo Patrícia Regina Barboza, Rodrigues Flaviane Kesia, Rozenchan Patrícia Bortman, Mendes-Correa Maria Cássia, Leite Olavo Henrique Munhoz, Schor Nestor, Girão Manoel João Castelo Batista, Barreto José   +11 more
doaj   +1 more source

Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia. [PDF]

, 2014
Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence.
A Castano, AM Verhagen, B Joseph, B Joseph, BP Eckelman, C Du, D Conte, DW Nicholson, E Varfolomeev, H Durkop, H Huang, JE Vince, JL Venero, K Rajalingam, K Saijo, K Saijo, M D'Amelio, M Gyrd-Hansen, M Luo, MA Burguillos, ML Block, N Muller-Sienerth, OH Voss, PL McGeer, S Kamada, SP Burke, ST Beug, T Tenev, V Bocchini, X Cui, Z Han   +30 more
core   +3 more sources