Results 11 to 20 of about 336,183 (263)

Molecular Dynamics Studies of Caspase-3 [PDF]

Biophysical Journal, 2003
Caspase-3 is a fundamental target for pharmaceutical interventions against a variety of diseases involving disregulated apoptosis. The enzyme is active as a dimer with two symmetry-related active sites, each featuring a Cys-His catalytic dyad and a selectivity loop, which recognizes the characteristic DEVD pattern of the substrate.
Sulpizi, M., Rothlisberger, U., Carloni, P.   +2 more
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MDA-MB-231 cell apoptosis in vitro induced by dihydromyricetin

浙江大学学报. 农业与生命科学版, 2012
To investigate the effect of dihydromyricetin (DMY) induction on MDA-MB-231 cell apoptosis and its mechanism, the changes of cell morphological characteristics were observed under inverted microscope.
ZHOU Fang-zhen, ZHANG Xiao-yuan, SUN Fen-yong, GUO Yong   +3 more
doaj   +1 more source

Altered of apoptotic markers of both extrinsic and intrinsic pathways induced by hepatitis C virus infection in peripheral blood mononuclear cells

Virology Journal, 2012
Background Chronic hepatitis C (CHC) has emerged as a leading cause of cirrhosis in the U.S. and across the world. To understand the role of apoptotic pathways in hepatitis C virus (HCV) infection, we studied the mRNA and protein expression patterns of ...
Albertoni Guilherme, Arnoni Carine Prisco, Latini Flávia Roche Moreira, Andrade Sheila Siqueira, Araújo Patrícia Regina Barboza, Rodrigues Flaviane Kesia, Rozenchan Patrícia Bortman, Mendes-Correa Maria Cássia, Leite Olavo Henrique Munhoz, Schor Nestor, Girão Manoel João Castelo Batista, Barreto José   +11 more
doaj   +1 more source

Astaxanthin effect on apoptotic biomarkers in methotrexate-induced liver injury

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022
Methotrexate is used in the treatment of cancer, psoriasis, rheumatoid arthritis and several other disorders. It has a hepatotoxic potential side effect. Patients who have no access to alternative medications face a serious   challenge as a result.
Sarah Saad Hamdan, Yassir Mustafa Kamal, Huda Jaber Waheed   +2 more
doaj   +1 more source

Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8 [PDF]

Journal of Molecular Biology, 2018
Canonical inflammasomes are multiprotein complexes that can activate both caspase-1 and caspase-8. Caspase-1 drives rapid lysis of cells by pyroptosis and maturation of interleukin (IL)-1β and IL-18. In caspase-1-deficient cells, inflammasome formation still leads to caspase-3 activation and slower apoptotic death, dependent on caspase-8 as an apical ...
Sagulenko, Vitaliya, Vitak, Nazarii, Vajjhala, Parimala, Vince, James E, Stacey, Katryn J   +4 more
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Effect of Gynura procumbens (Lour.) Merr. on the histopathology of the diabetic pancreas via caspase family expression [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Diabetes is a prominent cause of mortality globally, particularly in Indonesia. Elevated glucose levels stimulate insulin secretion from pancreatic β cells. A variety of drugs, including oral treatments and synthetic insulin, have been developed
Putri Cahaya Situmorang, Whika Febria Dewatisari, Andina Setyawati, Risma Dumiri Manurung, Eka Setiawan   +4 more
doaj   +1 more source

Metalloporphyrins inactivate caspase‐3 and ‐8 [PDF]

The FASEB Journal, 2005
ABSTRACT Activation of caspases represents one of the earliest biochemical indicators for apoptotic cell death. Therefore, measurement of caspase activity is a widely used and generally accepted method to determine apoptosis in a wide range of in vivo and in vitro settings.
Blumenthal, Signe B., Kiemer, Alexandra K., Tiegs, Gisa, Seyfried, Stefan, Höltje, Monika, Brandt, Birte, Höltje, Hans-Dieter, Zahler, Stefan, Vollmar, Angelika M.   +8 more
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FADD, Caspase-3, and Caspase-8 and Incidence of Coronary Events [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2017
Objective— To investigate the relationship between 3 markers of apoptosis, that is, FADD (Fas-associated death domain–containing protein), caspase-3, and caspase-8, and incidence of coronary events (CEs) in a population-based cohort study.
Xue L, Borné Y, Mattisson IY, Wigren M, Melander O, Ohro-Melander M, Bengtsson E, Fredrikson GN, Nilsson J, Engström G   +9 more
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Apoptotic Volume Decrease (AVD) Is Independent of Mitochondrial Dysfunction and Initiator Caspase Activation

Cells, 2012
Persistent cell shrinkage is a major hallmark of apoptotic cell death. The early-phase shrinkage, which starts within 30−120 min after apoptotic stimulation and is called apoptotic volume decrease (AVD), is known to be accomplished by activation of K ...
Takeshi Tsubata, Emi Maeno, Yasunobu Okada   +2 more
doaj   +1 more source

Pro-caspase-3 Is a Major Physiologic Target of Caspase-8 [PDF]

Journal of Biological Chemistry, 1998
The apoptotic signal triggered by ligation of members of the death receptor family is promoted by sequential activation of caspase zymogens. We show here that in a purified system, the initiator caspases-8 and -10 directly process the executioner pro-caspase-3 with activation rates (kcat/Km) of 8.7 x 10(5) and 2.8 x 10(5) M-1 s-1, respectively.
H R, Stennicke, J M, Jürgensmeier, H, Shin, Q, Deveraux, B B, Wolf, X, Yang, Q, Zhou, H M, Ellerby, L M, Ellerby, D, Bredesen, D R, Green, J C, Reed, C J, Froelich, G S, Salvesen   +13 more
openaire   +2 more sources