Results 21 to 30 of about 548,432 (354)

Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells. [PDF]

, 2009
The aim of this study was to determine whether heat-shock pretreatment exerted a protective effect against sorbitol-induced apoptotic cell death in K562, U937 and HeLa cell lines and whether such protection was associated with a decreased cytochrome c
Aventaggiato, Michele, De Martino, Luisa, Di Stefano, Carla, Fiorito, Filomena, Indelicato, Manuela, Marfe, Gabriella, Pucci, Bruna, Russo, Matteo A., Tafani, Marco   +8 more
core   +1 more source

DECAY, a novel Drosophilacaspase related to mammalian caspase-3 and caspase-7. [PDF]

Journal of Biological Chemistry, 1999
Caspases are key effectors of programmed cell death in metazoans. In Drosophila, four caspases have been described so far. Here we describe the identification and characterization of the fifth Drosophila caspase, DECAY. DECAY shares a high degree of homology with the members of the mammalian caspase-3 subfamily, particularly caspase-3 and caspase-7 ...
Dorstyn, L., Read, S., Quinn, L., Richardson, H., Kumar, S.   +4 more
openaire   +3 more sources

Clinical translation of [18F]ICMT-11 for measuring chemotherapy-induced caspase 3/7 activation in breast and lung cancer [PDF]

, 2018
Background: Effective anticancer therapy is thought to involve induction of tumour cell death through apoptosis and/or necrosis. [18F]ICMT-11, an isatin sulfonamide caspase-3/7-specific radiotracer, has been developed for PET imaging and shown to have ...
Aboagye, Eric O., Cleator, S., Coombes, R. C., Dubash, S. R., Heinzmann, K., Inglese, M., Kenny, Laura, Kozlowski, K., Lavdas, I., Lewanski, C., Lim, A. K., Masrour, N., Mauri, F., Merchant, S., Rama, N., Steel, J. F., Thornton, A.   +16 more
core   +1 more source

Effects of Scrophularia oxysepala Methanolic Extract on Early Stagesof Dimethylhydrazine-Induced Colon Carcinoma in Rats: ApoptosisPathway Approach [PDF]

Advanced Pharmaceutical Bulletin, 2022
Purpose: Colorectal cancer is one of the most prevalent cancers, worldwide. The presentstudy aimed to examine the effects of Scrophularia oxysepala (SO) methanolic extract on1,2-dimethylhydrazine (DMH) induced colon cancer model in the Wistar rats ...
Ali Namvaran, Mehdi Fazeli, Safar Farajnia, Gholamreza Hamidian, Hassan Rezazadeh   +4 more
doaj   +1 more source

Executioner caspase-3 and caspase-7 are functionally distinct proteases [PDF]

Proceedings of the National Academy of Sciences, 2008
Members of the caspase family of cysteine proteases play central roles in coordinating the stereotypical events that occur during apoptosis. Because the major executioner caspases, caspase-3 and caspase-7, exhibit almost indistinguishable activity toward certain synthetic peptide substrates, this has led to the widespread view that these ...
John G, Walsh, Sean P, Cullen, Clare, Sheridan, Alexander U, Lüthi, Christopher, Gerner, Seamus J, Martin   +5 more
openaire   +2 more sources

Apoptotic Volume Decrease (AVD) Is Independent of Mitochondrial Dysfunction and Initiator Caspase Activation

Cells, 2012
Persistent cell shrinkage is a major hallmark of apoptotic cell death. The early-phase shrinkage, which starts within 30−120 min after apoptotic stimulation and is called apoptotic volume decrease (AVD), is known to be accomplished by activation of K ...
Takeshi Tsubata, Emi Maeno, Yasunobu Okada   +2 more
doaj   +1 more source

Beneficial role of allicin from garlic in cervical cancer [PDF]

, 2008
Introduction: Cervical cancer remains a global health concern for females. Thus, in order to control cervical cancer, attempts are being made by researchers globally to somehow induce programmed cell death in the said cancerous cells.
Irfan Ahmad Ansari, Najmul Islam
core   +2 more sources

Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells [PDF]

, 2019
Modern molecular medicine demands techniques to efficiently deliver molecules directly into mammalian cells. As proteins are the final mediators of most cellular pathways, efficient intracellular protein delivery techniques are highly desired.
Braeckmans, Kevin, Brans, Toon, Declercq, Wim, Fraire, Juan, Raemdonck, Koen, Raes, Laurens, Roelandt, Ria, Saelens, Xavier, Stremersch, Stephan, Van Hoecke, Lien, Vandenabeele, Peter   +10 more
core   +2 more sources

Galactose:PEGamine coated gold nanoparticles adhere to filopodia and cause extrinsic apoptosis [PDF]

, 2018
Ultra-small gold nanoparticles, surface functionalised with a 50:50 ratio of a thiolated α-Galactose derivative and a thiolated hexaethylene glycol amine, are toxic to HSC-3 oral squamous carcinoma cells.
Espinosa Garcia, Cristina, Golding, Jon, Tzelepi, Konstantina, Williams, Phil   +3 more
core   +1 more source

The therapeutic effect of conditioned medium of human amniotic membrane stem cells on heart failure in rats [PDF]

مجله پزشکی دانشگاه علوم پزشکی تبریز, 2023
Background. The conditioned medium of stem cells plays an important role in the treatment of various diseases such as heart damage, but its molecular mechanisms are unknown.
Nahid Aboutaleb, Mahdieh Mehrab Mohseni, Mohammad Reza Khalilzadeh, Neda Mousavi Niri, Maryam Naseroleslami   +4 more
doaj   +1 more source