Results 21 to 30 of about 336,183 (263)

Characterization of Canine Caspase-3

Journal of Veterinary Medical Science, 2004
The canine caspase-3 gene was cloned and sequenced. The canine caspase-3 cDNA clone was 1473 base pairs in length and encoded 277 amino acids. The predicted amino acid sequence showed 88.4%, 88.0%, 85.9%, 65.9% and 60.6% homology with that of human, pig, mouse, chicken and zebra fish caspase-3, respectively.
SANO, Junichi, OGUMA, Keisuke, KANO, Rui, HASEGAWA, Atsuhiko   +3 more
openaire   +3 more sources

Substrate and Inhibitor-induced Dimerization and Cooperativity in Caspase-1 but Not Caspase-3 [PDF]

Journal of Biological Chemistry, 2013
Caspases are intracellular cysteine-class proteases with aspartate specificity that is critical for driving processes as diverse as the innate immune response and apoptosis, exemplified by caspase-1 and caspase-3, respectively. Interestingly, caspase-1 cleaves far fewer cellular substrates than caspase-3 and also shows strong positive cooperativity ...
Datta, Debajyoti, McClendon, Christopher L, Jacobson, Matthew P, Wells, James A   +3 more
openaire   +4 more sources

Kaposi's sarcoma herpesvirus microRNAs target caspase 3 and regulate apoptosis.

PLoS Pathogens, 2011
Kaposi's sarcoma herpesvirus (KSHV) encodes a cluster of twelve micro (mi)RNAs, which are abundantly expressed during both latent and lytic infection.
Guillaume Suffert, Georg Malterer, Jean Hausser, Johanna Viiliäinen, Aurélie Fender, Maud Contrant, Tomi Ivacevic, Vladimir Benes, Frédéric Gros, Olivier Voinnet, Mihaela Zavolan, Päivi M Ojala, Juergen G Haas, Sébastien Pfeffer   +13 more
doaj   +1 more source

Huntingtin inhibits caspase‐3 activation [PDF]

The EMBO Journal, 2006
Huntington's disease results from a mutation in the HD gene encoding for the protein huntingtin. The function of huntingtin, although beginning to be elucidated, remains largely unclear. To probe the prosurvival function of huntingtin, we modulate levels of wild-type huntingtin in a number of cellular and in vivo models.
Yu, Zhang, Blair R, Leavitt, Jeremy M, van Raamsdonk, Ioannis, Dragatsis, Dan, Goldowitz, Marcy E, MacDonald, Michael R, Hayden, Robert M, Friedlander   +7 more
openaire   +2 more sources

Aktifitas Caspase 3 sebagai Indikator Apoptosis pada Sel Kanker Ovarium

Indonesian Journal of Cancer, 2007
Kematian yang diakibatkan oleh kanker ovarium masih tetap tinggi meskipun sudah dengan penanganan yang agresif. Pemberian kemoterapi merupakan bagian penting selain tindakan operasi di dalam pengobatan kanker ovarium.
Bambang Dwipoyono
doaj   +1 more source

Caspase-3 and Caspase-6 cleave STAT1 in leukemic cells

Oncotarget, 2014
Signal Transducer and Activator of Transcription-1 (STAT1) is phosphorylated upon interferon (IFN) stimulation, which can restrict cell proliferation and survival. Nevertheless, in some cancers STAT1 can act in an anti-apoptotic manner. Moreover, certain malignancies are characterized by the overexpression and constitutive activation of STAT1. Here, we
Verena, Licht, Katrin, Noack, Bernhard, Schlott, Martin, Förster, Yvonne, Schlenker, Andreas, Licht, Oliver H, Krämer, Thorsten, Heinzel   +7 more
openaire   +3 more sources

The Role of Caspases in Melanoma Pathogenesis

Current Issues in Molecular Biology
Melanoma (malignant melanoma, MM) is an aggressive malignant skin cancer with an increasing incidence rate. The complete pathogenesis of MM in not clear.
Agnieszka Szmurło, Klaudia Dopytalska, Michał Szczerba, Elżbieta Szymańska, Alicja Petniak, Marcin Kocki, Janusz Kocki, Irena Walecka   +7 more
doaj   +1 more source

An improved superoxide-generating nanodevice for oxidative stress studies in cultured cells

Biotechnology Reports, 2015
The effects of reactive oxygen species on cells have attracted great attention from both physiological and pathological aspects. Superoxide (O2−) is the primary reactive oxygen species formed in animals.
Minoru Tamura, Sachio Kunihiro, Yuki Hamashima, Yuki Yoshioka, Shigenobu Tone, Kenji Kameda   +5 more
doaj   +1 more source

Overexpression of caspase-3 in hepatocellular carcinomas [PDF]

Modern Pathology, 2004
Caspase-3 is a downstream effector cysteine protease in the apoptotic pathway. It is ubiquitously expressed in normal human tissues including the liver. Overexpression and loss of expression of caspase-3 has been reported in diverse human malignancies. However, expression of caspase-3 in hepatocellular carcinoma (HCC) has not been studied.
Rajendra, Persad, Chen, Liu, Tsung-Teh, Wu, Patrick S, Houlihan, Stanley R, Hamilton, Anna M, Diehl, Asif, Rashid   +6 more
openaire   +2 more sources

Blood cytokine patterns suggest a modest inflammation phenotype in subjects with long‐chain fatty acid oxidation disorders

Physiological Reports, 2019
Excessive cellular accumulation or exposure to lipids such as long‐chain acylcarnitines (LCACs), ceramides, and others is implicated in cell stress and inflammation.
Colin S. McCoin, Melanie B. Gillingham, Trina A. Knotts, Jerry Vockley, Kikumi D. Ono‐Moore, Michael L. Blackburn, Jennifer E. Norman, Sean H. Adams   +7 more
doaj   +1 more source