Results 41 to 50 of about 548,432 (354)

The Role of Caspases in Melanoma Pathogenesis

Current Issues in Molecular Biology
Melanoma (malignant melanoma, MM) is an aggressive malignant skin cancer with an increasing incidence rate. The complete pathogenesis of MM in not clear.
Agnieszka Szmurło, Klaudia Dopytalska, Michał Szczerba, Elżbieta Szymańska, Alicja Petniak, Marcin Kocki, Janusz Kocki, Irena Walecka   +7 more
doaj   +1 more source

Blood cytokine patterns suggest a modest inflammation phenotype in subjects with long‐chain fatty acid oxidation disorders

Physiological Reports, 2019
Excessive cellular accumulation or exposure to lipids such as long‐chain acylcarnitines (LCACs), ceramides, and others is implicated in cell stress and inflammation.
Colin S. McCoin, Melanie B. Gillingham, Trina A. Knotts, Jerry Vockley, Kikumi D. Ono‐Moore, Michael L. Blackburn, Jennifer E. Norman, Sean H. Adams   +7 more
doaj   +1 more source

Caspase-3 deficiency during development increases vulnerability to hypoxic–ischemic injury through caspase-3-independent pathways

Neurobiology of Disease, 2006
Neonatal hypoxia–ischemia (H–I) is a common cause of perinatal morbidity and mortality leading to prominent activation of caspase-3 in the brain. Previous studies have shown that acute inhibition of caspase-3 can protect against neonatal H–I in rats.
Tim West, Madeliene Atzeva, David M. Holtzman   +2 more
doaj   +1 more source

Caspases disrupt the nuclear-cytoplasmic barrier [PDF]

, 2000
During apoptosis, caspases, a family of proteases, disassemble a cell by cleaving a set of proteins. Caspase-3 plays a major role in the dissassembly of the nucleus by processing several nuclear substrates.
Faleiro, L., Lazebnik, Y.
core   +1 more source

Expression of caspase-3, caspase-9, GDF-9 and IGF-1 genes in ovine oocytes cultured with optimum and elevated doses of Amphiregulin, Neuregulin-1 and Tumour necrosis factor-α in-vitro

Indian Journal of Animal Sciences, 2022
The present study was conducted to evaluate the expression of caspase-3, caspase-9, growth differentiation factor-9 (GDF-9) and insulin growth factor-1 (IGF-1) genes in oocytes cultured in vitro with optimum and elevated doses of amphiregulin (50 ng and
RAMESH HONDARAVALLI SOMASHETTY, NANDI SUMANTA, GIRISH KUMAR VENKATESH   +2 more
doaj   +1 more source

Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis [PDF]

, 2012
During apoptosis, hundreds of proteins are cleaved by caspases, most of them by the executioner caspase-3. However, caspase-7, which shares the same substrate primary sequence preference as caspase-3, is better at cleaving poly(ADP ribose) polymerase 1 ...
Blais, Véronique, Boucher, Dave, Denault, Jean-Bernard   +2 more
core   +1 more source

Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease [PDF]

, 2016
Previous studies showed that YAP1 is over-expressed in hepatocellular carcinoma (HCC). Here we observed higher expression of Yap1/Ctgf axis in dysplastic nodules and HCC chemically-induced in F344 rats, genetically susceptible to hepatocarcinogenesis ...
Avila, Matias A., Berasain, Carmen, Brozzetti, Stefania, Calvisi, Diego F., Daino, Lucia, Demartis, Maria I., Feo, Claudio F., Feo, Francesco, Latte, Gavinella, Pascale, Rosa M., Porcu, Alberto, Seddaiu, Maria A., Simile, Maria M., Tomasi, Maria L.   +13 more
core   +2 more sources

Caspase-3, Shears for Synapse Pruning [PDF]

Developmental Cell, 2014
Motor neurons regulate neuromuscular junction formation by using agrin to stimulate acetylcholine receptor clustering and using acetylcholine to disperse unnecessary receptor clusters on muscle fibers. Wang et al. (2014) now report in this issue of Developmental Cell a critical role for caspase-3 in intracellular mechanisms of acetylcholine-induced ...
Shen, Chengyong, Xiong, Wen C., Mei, Lin   +2 more
openaire   +2 more sources

Apoptosis in prostate carcinoma tissue: The role of caspase-3, caspase-1, and alkaline DNase activity [PDF]

Journal of Medical Biochemistry
Background: Prostate glandular tissue maintains a delicate balance between cellular proliferation and programmed cell death (apoptosis), ensuring the preservation of normal glandular architecture in healthy individuals.
Veljkovic Andrej, Hadzi-Djokic Jovan, Kocic Gordana, Li Xiaobo, Roumeliotis Stefanos, Sokolović Dušan, Klisic Aleksandra   +6 more
doaj   +1 more source

Monoamine oxidase-A modulates apoptotic cell death induced by staurosporine in human neuroblastoma cells [PDF]

, 2007
Monoamine oxidases (MAOs) are mitochondrial enzymes which control the levels of neurotransmitters in the brain and dietary amines in peripheral tissues via oxidative deamination. MAO has also been implicated in cell signalling. In this study, we describe
Billett E. E., Church R. J., Fowler C. J., Lowry O. H., Rodriguez M. J., Russell S. M., Song X., Tatton W. G.   +7 more
core   +1 more source