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Caspase 8: igniting the death machine [PDF]
Structure, 1999 Intense research into the signaling pathways of apoptosis has revealed a dominant role for proteases belonging to the caspase family, which in humans has 11 members at present. Two papers in the September issue of Structure with Folding & Design have for the first time revealed the structure of the key apoptotic initiator, caspase 8.
Guy S. Salvesen
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TNF-α contributes to sarcopenia through caspase-8/caspase-3/GSDME-mediated pyroptosis
Cell Death Discovery, 2023 Sarcopenia has become a leading cause of disability and mortality in the elderly. It has been reported that programmed cell death (PCD) is associated with the development of sarcopenia that is characterized by reduction of muscle fiber size and number ...
Jingying Wu +9 more
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Caspase‐8: regulating life and death [PDF]
Immunological Reviews, 2017 SummaryRoles for cell death in development, homeostasis, and the control of infections and cancer have long been recognized. Although excessive cell damage results in passive necrosis, cells can be triggered to engage molecular programs that result in cell death.
B. Tummers, D. Green
semanticscholar +4 more sources
Activation of the NLRP1B inflammasome by caspase-8. [PDF]
Commun BiolCleavage of the innate immune receptor NLRP1B by various microbial proteases causes the proteasomal degradation of its N-terminal fragment and the subsequent release of a C-terminal fragment that forms an inflammasome. We reported previously that metabolic stress caused by intracellular bacteria triggers NLRP1B activation, but the mechanism by which ...
Meade JJ +5 more
europepmc +4 more sources
Serum Interleukin-13 and Caspase 8 are Elevated in Prurigo Nodularis [PDF]
Acta Dermato-Venereologica, 2023 is missing (Short communication)
Teresa Ju +10 more
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Caspase-8: not so silently deadly
Clinical & Translational Immunology, 2017 Apoptosis is a caspase‐dependent programmed form of cell death, which is commonly believed to be an immunologically silent process, required for mammalian development and maintenance of cellular homoeostasis.
R. Feltham, J. Vince, K. Lawlor
semanticscholar +5 more sources
Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival [PDF]
Apoptosis, 2016 Impaired apoptosis is one of the hallmarks of cancer. Caspase-3 and -8 are key regulators of the apoptotic response and have been shown to interact with the calpain family, a group of cysteine proteases, during tumorigenesis.
X. Pu +6 more
semanticscholar +5 more sources
Caspase-3 and Caspase-8 in Patients with Nodular Goiter and Autoimmune Thyroiditis
Galician Medical Journal, 2016 The article presents results of the comparative analysis of peroxidation process activity of caspase-3 and caspase-8 in patients with thyroid adenoma (TA) and nodular goiter with autoimmune thyroiditis (NGAIT).
M. I. Sheremet +3 more
doaj +4 more sources
Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8. [PDF]
Journal of Molecular Biology, 2018 Canonical inflammasomes are multiprotein complexes that can activate both caspase-1 and caspase-8. Caspase-1 drives rapid lysis of cells by pyroptosis and maturation of interleukin (IL)-1β and IL-18. In caspase-1-deficient cells, inflammasome formation still leads to caspase-3 activation and slower apoptotic death, dependent on caspase-8 as an apical ...
V. Sagulenko +4 more
semanticscholar +5 more sources
Phosphorylation of caspase-8 by RSKs via organ-constrained effects controls the sensitivity to TNF-induced death [PDF]
Cell Death DiscoveryCaspase-8 (Casp8) serves as an initiator of apoptosis or a suppressor of necroptosis in context-dependent manner. Members of the p90 RSK family can phosphorylate caspase-8 at threonine-265 (T265), which can inactivate caspase-8 for bypassing caspase-8 ...
Peng He +4 more
doaj +2 more sources