Results 11 to 20 of about 6,015,666 (337)
Cellular Physiology and Biochemistry, 2017 Background: Long noncoding RNA (lncRNA) H19 is emerging as a vital regulatory molecule in the progression of different types of cancer and miR-675 is reported to be embedded in H19's first exon.
Jin Yan +11 more
doaj +2 more sources
The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8
Cell Research, 2021 Pyroptosis is a form of regulated cell death mediated by gasdermin family members, among which the function of GSDMC has not been clearly described. Herein, we demonstrate that the metabolite α-ketoglutarate (α-KG) induces pyroptosis through caspase-8 ...
Jia-yuan Zhang +12 more
semanticscholar +1 more source
The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis by Yersinia
Science, 2021 Cell death limits pathogens During infection, Yersinia inhibition of the protein kinase TAK1 triggers cleavage of the pore-forming protein gasdermin D (GSDMD), which leads to a kind of inflammatory cell death called pyroptosis.
Zengzhang Zheng +16 more
semanticscholar +1 more source
Diagnostics, 2021 Ovarian cancer remains a major diagnostic and therapeutic problem in modern gynecological oncology. For this reason, research which focuses on the search for new diagnostic markers and the assessment of their possible usefulness in clinical practice is ...
Aleksandra Mielczarek-Palacz +2 more
doaj +1 more source
Caspase‐8: A key protein of cross‐talk signal way in “PANoptosis” in cancer
International Journal of Cancer, 2021 Cysteinyl aspartate specific proteinase (Caspase)‐8 has long been considered a promoter of apoptosis and part of the mechanism by which cytotoxic drugs kill cancer cells.
Mingxia Jiang +5 more
semanticscholar +1 more source
The CULt of Caspase-8 Ubiquitination [PDF]
Cell, 2009 Caspase-8 is activated at the plasma membrane by the death-inducing signaling complex (DISC). Jin et al. (2009) show that polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC.
Guy S. Salvesen, Miklós Békés
openaire +3 more sources
GENETIC POLYMORHISM OF CASPASE 8 AND 9 IN IRAQ
The Iraqi Journal of Agricultural science, 2022 This study examined the potential association between polymorphisms of Caspase 9 −293del (rs4645982) and Caspase8−652 6N ins / del (rs3834129) and the danger of acute and chronic myeloid leukaemia in Iraqi population.
Duaa Abdullah , Reema M. Aloubaidy
doaj +1 more source
Obesity Science & Practice, 2023 Mechanisms underlying the negative effects of obesity on the brain are still unknown. Obesity is associated with oxidative stress in the brain and neuroinflammation that promotes neurodegenerative diseases.
Erick Gómez‐Apo +4 more
doaj +1 more source
Regulation of Caspase-8 Activity at the Crossroads of Pro-Inflammation and Anti-Inflammation
International Journal of Molecular Sciences, 2021 Caspase-8 has been classified as an apoptotic caspase, and its initial definition was an initiator of extrinsic cell death. During the past decade, the concept of caspase-8 functioning has been changed by findings of its additional roles in diverse ...
Jun-Hyuk Han +3 more
semanticscholar +1 more source
SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation
Signal Transduction and Targeted Therapy, 2020 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to respiratory illness and multi-organ failure in critically ill patients.
Shufen Li +10 more
semanticscholar +1 more source