Results 11 to 20 of about 459,603 (305)

Serum Interleukin-13 and Caspase 8 are Elevated in Prurigo Nodularis

Acta Dermato-Venereologica, 2023
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Teresa Ju, Angelina Labib, Leigh Nattkemper, Sarah Engle, Autum Auxier, Nathan Hahn, Sean Sissons, Jonathan T. Sims, Zhe Sun, Angela J. Okragly, Gil Yosipovitch   +10 more
doaj   +1 more source

Caspase-1 and Caspase-8 Cleave and Inactivate Cellular Parkin [PDF]

Journal of Biological Chemistry, 2003
Lesions in the parkin gene cause early onset Parkinson's disease by a loss of dopaminergic neurons, thus demonstrating a vital role for parkin in the survival of these neurons. Parkin is inactivated by caspase cleavage, and the major cleavage site is after Asp126.
Kahns, Søren, Kalai, Michaël, Jakobsen, Lene Diness, Clark, Brian F. C., Vandenabeele, Peter, Jensen, Poul Henning   +5 more
openaire   +4 more sources

Altered of apoptotic markers of both extrinsic and intrinsic pathways induced by hepatitis C virus infection in peripheral blood mononuclear cells

Virology Journal, 2012
Background Chronic hepatitis C (CHC) has emerged as a leading cause of cirrhosis in the U.S. and across the world. To understand the role of apoptotic pathways in hepatitis C virus (HCV) infection, we studied the mRNA and protein expression patterns of ...
Albertoni Guilherme, Arnoni Carine Prisco, Latini Flávia Roche Moreira, Andrade Sheila Siqueira, Araújo Patrícia Regina Barboza, Rodrigues Flaviane Kesia, Rozenchan Patrícia Bortman, Mendes-Correa Maria Cássia, Leite Olavo Henrique Munhoz, Schor Nestor, Girão Manoel João Castelo Batista, Barreto José   +11 more
doaj   +1 more source

The endogenous caspase-8 inhibitor c-FLIPL regulates ER morphology and crosstalk with mitochondria [PDF]

, 2014
Components of the death receptors-mediated pathways like caspase-8 have been identified in complexes at intracellular membranes to spatially restrict the processing of local targets.
A Filippini, A Golks, AV Nikonov, C Cerqua, C Frezza, C Giampietri, C Giampietri, C Giorgi, C Scaffidi, D Chandra, D Ferrari, DG Breckenridge, DG Breckenridge, E Area-Gomez, E S Marini, E Zampese, E Ziparo, EM Manders, F Gonzalvez, FW Ng, G Grynkiewicz, G Orso, GK Voeltz, I Sparkes, J Hu, J Zhang, JE Vance, JR Friedman, KH Shain, L Jozsef, L Scorrano, M Irmler, M Li, MJ Dayel, N Myhill, N Wittkopf, OM de Brito, OM de Brito, R Katayama, R Rizzuto, R Rizzuto, R Schweigreiter, R Xiang, RS Misra, S Conti, S Petrungaro, SH Park, T Simmen, TW Day, WC Yeh, Y Shibata, Y Shibata, Y Shibata, ZT Schug   +53 more
core   +2 more sources

An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages

Cell Reports, 2020
Summary: Pyroptosis has emerged as a key mechanism by which inflammasomes promote host defense against microbial pathogens and sterile inflammation. Gasdermin D (GSDMD)-mediated cell lysis is a hallmark of pyroptosis, but our understanding of cell death ...
Nathalia Moraes de Vasconcelos, Nina Van Opdenbosch, Hanne Van Gorp, Rosa Martín-Pérez, Annalisa Zecchin, Peter Vandenabeele, Mohamed Lamkanfi   +6 more
doaj   +1 more source

Beneficial role of allicin from garlic in cervical cancer [PDF]

, 2008
Introduction: Cervical cancer remains a global health concern for females. Thus, in order to control cervical cancer, attempts are being made by researchers globally to somehow induce programmed cell death in the said cancerous cells.
Irfan Ahmad Ansari, Najmul Islam
core   +2 more sources

Study of Caspase 8 Inhibition for the Management of Alzheimer’s Disease: A Molecular Docking and Dynamics Simulation

Molecules, 2020
Alzheimer’s disease (AD) is the most common type of dementia and usually manifests as diminished episodic memory and cognitive functions. Caspases are crucial mediators of neuronal death in a number of neurodegenerative diseases, and caspase 8 is ...
Syed Sayeed Ahmad, Meetali Sinha, Khurshid Ahmad, Mohammad Khalid, Inho Choi   +4 more
doaj   +1 more source

A mutation in caspase-9 decreases the expression of BAFFR and ICOS in patients with immunodeficiency and lymphoproliferation [PDF]

, 2015
Lymphocyte apoptosis is mainly induced by either death receptor-dependent activation of caspase-8 or mitochondria-dependent activation of caspase-9. Mutations in caspase-8 lead to autoimmunity/lymphoproliferation and immunodeficiency. This work describes
Boggio, E, Cappellano, G, Chiocchetti, A., Clemente, N, Dianzani, C, Dianzani, I, Dianzani, U, Gigliotti, Cl, Notarangelo, Ld, Orilieri, E, Pignata, C, Quinti, Isabella, Ramenghi, U, Santoro, C, Toth, E, Valletti, Pa   +15 more
core   +2 more sources

Caspase-8 Potentiates Triglyceride (TG)-Induced Cell Death of THP-1 Macrophages via a Positive Feedback Loop

Korean Journal of Clinical Laboratory Science, 2021
Hypertriglyceridemia is the main risk factor for atherosclerosis. It is reported that triglyceride (TG) induces macrophage cell death, and is involved in the formation of plaques and development of atherosclerosis.
Byung Chul Jung, Jaewon Lim, Sung Hoon Kim, Yoon Suk Kim   +3 more
doaj   +1 more source

Caspase-1 engagement and TLR-induced c-FLIP expression suppress ASC/caspase-8-dependent apoptosis by inflammasome sensors NLRP1b and NLRC4 [PDF]

, 2017
The caspase activation and recruitment domain (CARD)-based inflammasome sensors NLRP1b and NLRC4 induce caspase-1-dependent pyroptosis independent of the inflammasome adaptor ASC.
D'Hont, Jinke, Demon, Dieter, Gonçalves, Amanda, Hochepied, Tino, Kanneganti, Thirumala-Devi, Krautwald, Stefan, Lamkanfi, Mohamed, Matusiak, Magdalena, Moraes de Vasconcelos, Nathalia, Van Gorp, Hanne, Van Hauwermeiren, Filip, Van Opdenbosch, Nina, Vande Walle, Lieselotte, Verdonckt, Maarten, Viana Saavedra, Pedro Henrique   +14 more
core   +2 more sources