Results 81 to 90 of about 456,031 (305)
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2019 BACKGROUND AND OBJECTIVE: Studies have shown that ibuprofen can have an anti-cancer effect on cervical cells, although the mechanism of this effect is not well known in cellular and molecular terms.
E Ghadiri, R Ahmadi, E Rostami
doaj
Contribution of caspase-8 to apoptosis of axotomized rat retinal ganglion cells in vivo
Neurobiology of Disease, 2003 We have investigated the role of caspase-8 and its mode of activation during apoptosis of adult rat retinal ganglion cells (RGCs) in vivo. Retinal pro-caspase-8 expression was almost completely restricted to RGCs.
J.H Weishaupt +5 more
doaj +1 more source
RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions [PDF]
, 2014 Accumulation of unfolded proteins in the endoplasmic reticulum (ER) causes ER stress and results in the activation of the unfolded protein response (UPR), which aims at restoring ER homeostasis.
Aguileta, Miguel +8 more
core +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
dsDNA ASCs for caspase 8-mediated apoptosis [PDF]
Cell Death & Differentiation, 2013 In the dim and distant past of research, there was only place for one form of cell death. Necrosis was the only known way for cells to die, and pathologists generally defined all cells with a dying phenotype as necrotic. This restricted view was challenged in 1972 when Kerr et al.1 defined apoptosis as a novel form of cell death, which was ...
Grabinger, T. +2 more
openaire +4 more sources
Caspase‐8 Variant G Regulates Rheumatoid Arthritis Fibroblast‐Like Synoviocyte Aggressive Behavior
ACR Open Rheumatology, 2022 Objective Fibroblast‐like synoviocytes (FLS) play a pivotal role in rheumatoid arthritis (RA) by contributing to synovial inflammation and progressive joint damage. An imprinted epigenetic state is associated with the FLS aggressive phenotype.
Cecilia Ansalone +15 more
doaj +1 more source
Ginger extract (Zingiber officinale Roscoe) triggers apoptosis in hepatocarcinogenesis induced rats [PDF]
, 2008 Ginger extract has been reported previously by our group to exhibit anticancer and an-tioxidant effects by reducing tumour burden and lipid peroxidation respectively in he-patocarcinogenesis induced rats.
Harlianshah H, +7 more
core
Exposure of a tendon extracellular matrix to synovial fluid triggers endogenous and engrafted cell death: A mechanism for failed healing of intrathecal tendon injuries [PDF]
, 2016 Aim: The purpose of this study was to investigate the effect of normal synovial fluid (SF) on exposed endogenous tendon-derived cells (TDC) and engrafted mesenchymal stem cells (MSCs) within the tendon extracellular matrix. Methods: Explants from equine
Dudhia, J +3 more
core +3 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Caspase-8: Clipping off RIG-I Signaling [PDF]
Immunity, 2011 Activation of the RIG-I signaling molecule is essential for antiviral immunity but mechanisms downmodulating the response are ill defined. In this issue of Immunity, Rajput et al. (2011) describe caspase-8-mediated RIP1 cleavage as a key step for restricting RIG-I signaling.
Roth, Susanne, Ruland, Jürgen
openaire +2 more sources