Advanced Science, EarlyView.A method is developed for conducting genome‐wide CRISPR/Cas9 screening of monocyte infiltration in vivo (CRISPR‐MI) that is easily adaptable across a variety of disease models. Through the combination of CRISPR‐MI and scRNA‐Seq, this study discovers that Trem2 is a key regulator of early monocyte infiltration in abdominal aortic aneurysm (AAA ...
Haocheng Lu +30 more
wiley +1 more source
CASPASES -2, -3, -6, AND -9, BUT NOT CASPASE-1, ARE ACTIVATED IN SEPSIS-INDUCED THYMOCYTE APOPTOSIS
, 2000 Kevin W. Tinsley +7 more
openalex +1 more source
Homeostasis of Gut Microbiota Protects against Susceptibility to Fungal Pneumonia
Advanced Science, EarlyView.Fungal pneumonia induces inflammation, shown by heightened IL‐6, IL‐1β, TNF‐α levels and a growth in Staphylococcus in the alveolar flora. The gut microbiota, acting through the gut‐lung axis via blood, impacts fungal pneumonia susceptibility by altering lung metabolism and inflammatory responses.
Jian Ji +12 more
wiley +1 more source
Inhibition of Caspase 3 and Caspase 9 Mediated Apoptosis: A Multimodal Therapeutic Target in Traumatic Brain Injury. [PDF]
Curr Neuropharmacol, 2023 Unnisa A, Greig NH, Kamal MA.
europepmc +1 more source
cDNA cloning and promoter analysis of rat caspase-9 [PDF]
, 2001 Junichiro Nishiyama +3 more
openalex +1 more source
Advanced Science, EarlyView.Emodin targets BCL‐10 to modulate the BCL‐10/MALT1 complex, thereby suppressing NF‐κB activation and significantly exerting multiorgan protective effects in sepsis. Abstract Sepsis is a life‐threatening condition caused by dysregulated host responses to infection, characterized by excessive inflammation and abnormal coagulation.
Xiaolong Xu +16 more
wiley +1 more source
Molecular Docking and Simulation-Binding Analysis of Plant Phytochemicals with the Hepatocellular Carcinoma Targets Epidermal Growth Factor Receptor and Caspase-9. [PDF]
Molecules, 2023 Mustafa G +4 more
europepmc +1 more source
Activation of caspase-8 in 3-deazaadenosine-induced apoptosis of U-937 cells occurs downstream of caspase-3 and caspase-9 without Fas receptor-ligand interaction [PDF]
, 2001 Yeo-Jin Chae +5 more
openalex +1 more source
Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5
Advanced Science, EarlyView.Okanin suppresses colorectal cancer growth by directly targeting PRDX5. This natural compound selectively binds peroxiredoxin 5 (PRDX5), inhibiting its activity and inducing WSB1‐mediated degradation. PRDX5 loss elevates ROS, suppresses GPX4 via SIAH2, and further triggers cell death (apoptosis and ferroptosis).
Ji Zhong Zhao +9 more
wiley +1 more source