Results 171 to 180 of about 4,742,958 (308)

Linalool attenuated ischemic injury in PC12 cells through inhibition of caspase-3 and caspase-9 during apoptosis. [PDF]

Food Sci Nutr, 2023
Hosseini A, Pourheidar E, Rajabian A, Asadpour E, Hosseinzadeh H, Sadeghnia HR.   +5 more
europepmc   +1 more source

Genetically Engineered IL12/CSF1R‐Macrophage Membrane‐Liposome Hybrid Nanovesicles for NIR‐II Fluorescence Imaging‐Guided and Membrane‐Targeted Mild Photothermal‐Immunotherapy of Glioblastoma

Advanced Science, EarlyView.
A theranostic nanoplatform is formulated with NIR‐II emissive lipophilic cyanine dye IRC18 to intercalate into genetically engineered IL12/CSF1R‐macrophage membrane‐liposome hybrid nanovesicles, which assists to achieve blood–brain barrier crossing, glioblastoma targeting, NIR‐II fluorescence imaging, image‐guided membrane‐targeted mild photothermal ...
Pengfei Chen, Yue Liu, Haiyan Huang, Menglong Li, Hui Xie, Shubham Roy, Jingsi Gu, Jian Jin, Kai Deng, Lixin Du, Bing Guo   +10 more
wiley   +1 more source

Identification of a Caspase-9 Substrate and Detection of Its Cleavage in Programmed Cell Death during Mouse Development [PDF]

, 2001
Keiko Nakanishi, Masumi Maruyama, Takehiko Shibata, Nobuhiro Morishima   +3 more
openalex   +1 more source

PRMT5 Inhibitor Synergizes with Chemotherapy to Induce Resembling Mismatch Repair Deficiency and Enhance Anti‐TIGIT Therapy in Microsatellite‐Stable Colorectal Cancer

Advanced Science, EarlyView.
Microsatellite‐stable (MSS) colorectal cancer (CRC) resists immunotherapy. PRMT5 inhibition enhances CPT‐11 sensitivity, inducing a PMS2‐deficient‐like state and cytosolic dsDNA release, which activates the cGAS‐STING pathway to promote anti‐tumor immunity. However, this combination therapy upregulates TIGIT expression on CD8+ T cells, and the addition
Jiang Zhu, Shenao Fu, Xi Zou, Hanjiang Zeng, Guangzu Cui, Yinghui Peng, Diya Tang, Fan Zhang, Hong Shen, Shan Zeng, Ying Han   +10 more
wiley   +1 more source

Targeted biallelic integration of an inducible Caspase 9 suicide gene in iPSCs for safer therapies. [PDF]

Mol Ther Methods Clin Dev, 2022
Wunderlich S, Haase A, Merkert S, Jahn K, Deest M, Frieling H, Glage S, Korte W, Martens A, Kirschning A, Zeug A, Ponimaskin E, Göhring G, Ackermann M, Lachmann N, Moritz T, Zweigerdt R, Martin U.   +17 more
europepmc   +1 more source

Pia Mater‐Penetrable Lipopolymer Nanoparticles for Gliocyte‐Targeted IL‐10 mRNA Therapy Alleviate Paclitaxel‐Induced Peripheral Neuropathy

Advanced Science, EarlyView.
The P6CIT lipopolymer demonstrates superior transfection efficacy in the spinal cord and DRG, as well as enhanced penetration of the pia mater compared to the MC3 ionizable lipid. Intrathecal delivery of P6CIT LPNPs enables effective transfection in the gliocytes in the spinal cord and DRG.
Xinrou Lin, Lingyu Wei, Xiangpen Li, Ling Zeng, Yingsen Tang, Hongjin Wang, Hengjian Lu, Chenguang Li, Hongxuan Wang, Jinjin Chen, Ying Peng   +10 more
wiley   +1 more source

PMA induces apoptosis in the SNU-C4 colon cancer cells through caspase-9 independently of caspase-3 and -8

, 2000
Shaun G. Weller, Robert C. Penington, William E. Karnes   +2 more
openalex   +1 more source

Oxidative stress and increased levels of apoptosis (Cytochrome C, Caspase 3 and 9) in patients with male-factor infertility. [PDF]

, 2001
X Wang, Rakesh Sharma, Pavithra Ranganathan, A.J. Thomas, Tommaso Falcone, Ashok Agarwal   +5 more
openalex   +1 more source

Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy. [PDF]

Acta Pharmacol Sin, 2023
Li L, Song JJ, Zhang MX, Zhang HW, Zhu HY, Guo W, Pan CL, Liu X, Xu L, Zhang ZY.   +9 more
europepmc   +1 more source

Mechanical Forces Guide Axon Growth through the Nigrostriatal Pathway in an Organotypic Model

Advanced Science, EarlyView.
Nano‐pulling is a magnetic nanoparticle‐based technology for guiding and promoting the axon growth of induced pluripotent stem cell‐derived dopaminergic neurospheres in vitro or neural progenitors transplanted in the brain tissue. Fine control of axon guidance is essential for reconstructing neural networks and restoring functional connectivity in the ...
Sara De Vincentiis, Elena Capitanini, Karen Kira, Claudia Dell'Amico, Jun Takahashi, Marco Onorati, Fabian Raudzus, Vittoria Raffa   +7 more
wiley   +1 more source