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Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death [PDF]

open access: yesNature Communications, 2017
Apoptosis is a genetically regulated cell suicide programme mediated by activation of the effector caspases 3, 6 and 7. If apoptotic cells are not scavenged, they progress to a lytic and inflammatory phase called secondary necrosis.
Lindsey Mayes   +2 more
exaly   +3 more sources
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SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation

Signal Transduction and Targeted Therapy, 2020
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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

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Caspase Allostery and Conformational Selection

Chemical Reviews, 2016
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Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

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Nature Catalysis, 2020
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Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

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Activity of caspase-8 determines plasticity between cell death pathways

Nature, 2019
Kim Newton, Debra L Dugger, Yue Zhang
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