Results 21 to 30 of about 421,499 (328)

Astaxanthin effect on apoptotic biomarkers in methotrexate-induced liver injury

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022
Methotrexate is used in the treatment of cancer, psoriasis, rheumatoid arthritis and several other disorders. It has a hepatotoxic potential side effect. Patients who have no access to alternative medications face a serious   challenge as a result.
Sarah Saad Hamdan, Yassir Mustafa Kamal, Huda Jaber Waheed   +2 more
doaj   +1 more source

TRAIL Enhances Apoptosis of Human Hepatocellular Carcinoma Cells Sensitized by Hepatitis C Virus Infection: Therapeutic Implications [PDF]

, 2014
Hepatitis C virus (HCV) infection causes chronic liver diseases leading to hepatocellular carcinoma (HCC) and liver failure. We have previously shown that HCV sensitizes hepatocytes to mitochondrial apoptosis via the TRAIL death receptors DR4 and DR5 ...
Cho, Eun Kyung, Chung, Raymond T., Jang, Jae Young, Jeong, Soung Won, Kim, Boo Sung, Kim, Hong Soo, Kim, Sang Gyune, Kim, Seong-Jun, Kim, Young Seok, Lee, Sae Hwan, Lee, Woong Cheul, Lin, Wenyu, Park, Eui Ju   +12 more
core   +10 more sources

Apoptosis and autophagy: Regulation of caspase‐9 by phosphorylation [PDF]

The FEBS Journal, 2009
Cell death by the process of apoptosis plays important roles in development, tissue homeostasis, diseases and drug responses. The cysteine aspartyl protease caspase‐9 plays a central role in the mitochondrial or intrinsic apoptotic pathway that is engaged in response to many apoptotic stimuli.
Allan, Lindsey A., Clarke, Paul R.
openaire   +3 more sources

Caspase 9 and Caspase 3 Immunohistochemical Pattern in Skeletal and Cardiac Muscles at Different Times after Death: An Experimental Study on PMI Estimation

Diagnostics, 2021
(1) Background: The estimation of the post mortem interval (PMI) is a challenge for forensic pathologists because data emerging from methods commonly applied are not always conclusive, since several conditions exist that may affect the reliability of ...
Cristina Mondello, Chiara Stassi, Letteria Minutoli, Gennaro Baldino, Angela Alibrandi, Giovanni Francesco Spatola, Maria Laura Uzzo, Antonio Micali, Domenico Puzzolo, Alessio Asmundo, Elvira Ventura Spagnolo   +10 more
doaj   +1 more source

Caspase-9 and effector caspases have sequential and distinct effects on mitochondria [PDF]

Oncogene, 2005
Proapoptotic Bcl-2 family members alter mitochondrial permeability resulting in the release of apoptogenic factors that initiate a caspase cascade. These changes are well described; however, the effects of caspases on mitochondrial function are less well characterized.
Anne M. King, Lane M Coffey, Rebeka G Perez, Enrique Cepero, Lawrence H. Boise   +4 more
openaire   +3 more sources

Caspase 8 and caspase 9 gene polymorphisms and susceptibility to gastric cancer [PDF]

Gastric Cancer, 2011
Caspase-8 (CASP8) and caspase-9 (CASP9) play crucial roles in regulating apoptosis, and their functional polymorphisms may alter cancer risk. Our aim was to investigate the association of CASP8 and CASP9 gene polymorphisms with gastric cancer (GC) susceptibility.We undertook a case-control study of 88 GC cases and 480 controls to investigate the ...
Emmanouil Liamarkopoulos, Spyros Rizos, Maria Gazouli, Nikolaos Nikiteas, Nikolaos Tzanakis, Gerasimos Aravantinos, George Theodoropoulos   +6 more
openaire   +3 more sources

A mutation in caspase-9 decreases the expression of BAFFR and ICOS in patients with immunodeficiency and lymphoproliferation [PDF]

, 2015
Lymphocyte apoptosis is mainly induced by either death receptor-dependent activation of caspase-8 or mitochondria-dependent activation of caspase-9. Mutations in caspase-8 lead to autoimmunity/lymphoproliferation and immunodeficiency. This work describes
Boggio, E, Cappellano, G, Chiocchetti, A., Clemente, N, Dianzani, C, Dianzani, I, Dianzani, U, Gigliotti, Cl, Notarangelo, Ld, Orilieri, E, Pignata, C, Quinti, Isabella, Ramenghi, U, Santoro, C, Toth, E, Valletti, Pa   +15 more
core   +2 more sources

A non-apoptotic role for caspase-9 in muscle differentiation [PDF]

, 2008
Caspases, a family of cysteine proteases most often investigated for their roles in apoptosis, have also been demonstrated to have functions that are vital for the efficient execution of cell differentiation.
Fearnhead, Howard O, Howley, Breege A, McMahon, Jill M, Mohr, Andrea, Murray, Thomas VA, Ritter, Thomas, Stanley, Alanna, Zwacka, Ralf   +7 more
core   +1 more source

Regulation of the Apaf-1/Caspase-9 Apoptosome by Caspase-3 and XIAP [PDF]

Journal of Biological Chemistry, 2003
The apoptosome is a multiprotein complex comprising Apaf-1, cytochrome c, and caspase-9 that functions to activate caspase-3 downstream of mitochondria in response to apoptotic signals. Binding of cytochrome c and dATP to Apaf-1 in the cytosol leads to the assembly of a heptameric complex in which each Apaf-1 subunit is bound noncovalently to a ...
Junshan Hao, Jean Wang, Ruomei Yang, Robert C. Armstrong, Kevin J. Tomaselli, Hua Zou, Stephen W. Fesik, Chaohong Sun, Joe C. Wu   +8 more
openaire   +3 more sources

Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells. [PDF]

, 2009
The aim of this study was to determine whether heat-shock pretreatment exerted a protective effect against sorbitol-induced apoptotic cell death in K562, U937 and HeLa cell lines and whether such protection was associated with a decreased cytochrome c
Aventaggiato, Michele, De Martino, Luisa, Di Stefano, Carla, Fiorito, Filomena, Indelicato, Manuela, Marfe, Gabriella, Pucci, Bruna, Russo, Matteo A., Tafani, Marco   +8 more
core   +1 more source