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Diagnostics, 2021 (1) Background: The estimation of the post mortem interval (PMI) is a challenge for forensic pathologists because data emerging from methods commonly applied are not always conclusive, since several conditions exist that may affect the reliability of ...
Cristina Mondello +10 more
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Aquaculture and Fisheries, 2021 During low tide intertidal organisms face severe temperature fluctuations. This situation may be more pronounced in the context of climate change.
Fengshen Zhao, Heding Shen
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Apoptosis and autophagy: Regulation of caspase‐9 by phosphorylation [PDF]
The FEBS Journal, 2009 Cell death by the process of apoptosis plays important roles in development, tissue homeostasis, diseases and drug responses. The cysteine aspartyl protease caspase‐9 plays a central role in the mitochondrial or intrinsic apoptotic pathway that is engaged in response to many apoptotic stimuli.
Allan, Lindsey A., Clarke, Paul R.
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Caspase-9 and effector caspases have sequential and distinct effects on mitochondria [PDF]
Oncogene, 2005 Proapoptotic Bcl-2 family members alter mitochondrial permeability resulting in the release of apoptogenic factors that initiate a caspase cascade. These changes are well described; however, the effects of caspases on mitochondrial function are less well characterized.
Anne M. King +4 more
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Astaxanthin effect on apoptotic biomarkers in methotrexate-induced liver injury
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022 Methotrexate is used in the treatment of cancer, psoriasis, rheumatoid arthritis and several other disorders. It has a hepatotoxic potential side effect. Patients who have no access to alternative medications face a serious challenge as a result.
Sarah Saad Hamdan +2 more
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Caspase 8 and caspase 9 gene polymorphisms and susceptibility to gastric cancer [PDF]
Gastric Cancer, 2011 Caspase-8 (CASP8) and caspase-9 (CASP9) play crucial roles in regulating apoptosis, and their functional polymorphisms may alter cancer risk. Our aim was to investigate the association of CASP8 and CASP9 gene polymorphisms with gastric cancer (GC) susceptibility.We undertook a case-control study of 88 GC cases and 480 controls to investigate the ...
Emmanouil Liamarkopoulos +6 more
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Исследования и практика в медицине, 2021 Purpose of the study. Studying the dynamics of factors of apoptosis in mitochondria of skin and tumors cells in female mice with melanoma growth stimulated by chronic neurogenic pain. Material and methods.
E. M. Frantsiyants +6 more
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Regulation of the Apaf-1/Caspase-9 Apoptosome by Caspase-3 and XIAP [PDF]
Journal of Biological Chemistry, 2003 The apoptosome is a multiprotein complex comprising Apaf-1, cytochrome c, and caspase-9 that functions to activate caspase-3 downstream of mitochondria in response to apoptotic signals. Binding of cytochrome c and dATP to Apaf-1 in the cytosol leads to the assembly of a heptameric complex in which each Apaf-1 subunit is bound noncovalently to a ...
Junshan Hao +8 more
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MDA-MB-231 cell apoptosis in vitro induced by dihydromyricetin
浙江大学学报. 农业与生命科学版, 2012 To investigate the effect of dihydromyricetin (DMY) induction on MDA-MB-231 cell apoptosis and its mechanism, the changes of cell morphological characteristics were observed under inverted microscope.
ZHOU Fang-zhen +3 more
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Al-Azhar Assiut Medical Journal, 2017 Background Vitiligo is the most common depigmentation disorder of the skin. It is considered a multifactorial disorder. However, its exact etiology is unknown.
Eman R.M Hofny +4 more
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