Results 131 to 140 of about 29,420 (294)

Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance. [PDF]

, 2016
The fungal pathogen Candida glabrata has emerged as a major health threat since it readily acquires resistance to multiple drug classes, including triazoles and/or echinocandins.
Alexander, B.D., Farmakiotis, D., Healey, K.R., Jimenez-Ortigosa, C., Kontoyiannis, D.P., Lockhart, S.R., Perez, W.B., Perlin, D.S., Sanglard, D., Shor, E., Sobel, J.D., Taj-Aldeen, S.J., Zhao, Y.   +12 more
core   +1 more source

Addition of 17-(allylamino)-17-demethoxy-geldanamycin to a suboptimal caspofungin treatment regimen in neutropenic rats with invasive pulmonary aspergillosis delays the time to death but does not enhance the overall therapeutic efficacy [PDF]

, 2017
Caspofungin (CAS) which is used as salvage therapy in patients with invasive pulmonary aspergillosis (IPA) inhibits the 1,3-β-D-glucan synthesis in Aspergillus fumigatus.
Bakker-Woudenberg, I.A.J.M. (Irma), Eadie, K. (Kimberley), Kate, M.T. (Marian) ten, Refos, J. (Jeanine), Sande, W.W.J. (Wendy) van de, Verbrugh, H.A. (Henri), Vonk, A.G. (Alieke)   +6 more
core   +1 more source

Treatment of chronic pulmonary blastomycosis with caspofungin

Journal of Medical Microbiology, 2011
Current practice guidelines recommend that pulmonary blastomycosis be treated with antifungal agents such as amphotericin B and itraconazole. Echinocandins are not recommended because of poor in vitro activity against Blastomyces dermatitidis and lack of supporting clinical data.
Marc Ghannoum, Bich Nguyen, Christian Couture, Valery Lavergne, Joelle Mardini   +4 more
openaire   +3 more sources

Caspofungin resistance in Candidaalbicans: genetic factors and synergistic compounds for combination therapies

Brazilian Journal of Microbiology, 2022
F. Perrine-Walker
semanticscholar   +1 more source

Link between Heat Shock Protein 90 and the Mitochondrial Respiratory Chain in the Caspofungin Stress Response of Aspergillus fumigatus

Antimicrobial Agents and Chemotherapy, 2019
Aspergillus fumigatus is an opportunistic mold responsible for invasive aspergillosis. Triazoles (e.g., voriconazole) represent the first-line treatment, but emerging resistance is of concern.
M. Aruanno, D. Bachmann, D. Sanglard, F. Lamoth   +3 more
semanticscholar   +1 more source

Development and Quality Control of a Population Pharmacokinetic Model Library for Caspofungin

Pharmaceutics
Background: Caspofungin is an echinocandin antifungal agent commonly used as the first-line therapy for invasive candidiasis, salvage therapy for invasive aspergillosis, and empirical therapy for presumed fungal infections.
Nuo Xu, Yufei Shi, Yixue Wang, Wenyao Mak, Wenyu Yang, Kar Weng Ng, Yue Wu, Zhijia Tang, Qingfeng He, Gangfeng Yan, Xiaoqiang Xiang, Xiao Zhu   +11 more
doaj   +1 more source

Proof of Concept for MBT ASTRA, a Rapid Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry (MALDI-TOF MS)-Based Method To Detect Caspofungin Resistance in Candida albicans and Candida glabrata

Journal of Clinical Microbiology, 2018
The incidence of candidemia caused by Candida albicans and Candida glabrata is constantly increasing and is accompanied by the rising use of the few available antifungals.
M. Vatanshenassan, T. Boekhout, C. Lass‐Flörl, M. Lackner, S. Schubert, M. Kostrzewa, K. Sparbier   +6 more
semanticscholar   +1 more source

Efficacy and safety of caspofungin for the treatment of invasive pulmonary aspergillosis in patients with chronic obstructive pulmonary disease

Journal of International Medical Research
Objectives We assessed the efficacy of a 3-week primary or salvage caspofungin regimen in patients with chronic obstructive pulmonary disease (COPD) and concomitant proven or suspected invasive pulmonary aspergillosis (IPA).
Shaoqiang Li, Zhengtu Li, Penglei Wang, Yangqing Zhan, Jiaxing Xie, Feng Ye   +5 more
doaj   +1 more source

Efficacy of caspofungin dose escalation against Candida albicans and Candida glabrata clinical isolates [PDF]

, 2016
Munkánk során meghatároztuk a caspofungin által kifejtett ölési rátát RPMI-1640-ben, valamint 50% humán szérummal kiegészített tápközegben C. albicans és C. glabrata klinikai izolátumok ellen.
Domán, Marianna
core  

Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia [PDF]

, 2007
In vitro susceptibility of 58 isolates of Pichia anomala to five antifungal drugs using two broth microdilution methods (CLSI and EUCAST) was analyzed. Low susceptibility to itraconazole was observed.
Colombo, Arnaldo Lopes, Costa, Silvia Figueiredo, Dias, Maria Beatriz G. Souza, Duboc de Almeida, Gisele Madeira, Levin, Anna S., Martins, Marilena dos Anjos, Melhem, Marcia de Souza Carvalho, Moretti, Maria Luiza, Nucci, Marcio, Ribeiro da Matta, Vania Lucia, Rodero, Laura   +10 more
core   +2 more sources