Results 61 to 70 of about 3,617 (131)

Efficacy of Tocilizumab in Limbic Encephalitis with Anti-CASPR2 Antibodies

Case Reports in Neurological Medicine, 2020
We report the case of a 64-year-old man who presented with subacute memory, balance impairment, behavioral and mood changes, and epileptic seizures. Magnetic resonance imaging (MRI) showed bilateral hippocampal abnormalities.
Maurizio Benucci, Luciana Tramacere, Maria Infantino, Mariangela Manfredi, Valentina Grossi, Arianna Damiani, Francesca Li Gobbi, Maristella Piccininni, Gaetano Zaccara, Massimo Cincotta   +9 more
doaj   +1 more source

Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management

MedComm, Volume 7, Issue 7, July 2026.
Epilepsy is a heterogeneous and chronically evolving brain network disorder. This review integrates epidemiological burden, psychiatric comorbidities, and cyclic seizure patterns with multiscale pathogenic mechanisms, including ion‐channel dysfunction, synaptic transmission defects, neuroinflammation, metabolic and mitochondrial dysfunction, and ...
Jian Liu, Xinyan Wu, Ting Yin, Feining Huang, Manqi Kong, Yu Yang, Zinan Liu, Jiabin Yu, Tianpeng Zhang   +8 more
wiley   +1 more source

Case Report: CASPR2-associated autoimmune encephalitis with NF155 Antibody-positive autoimmune nodopathies: a rare case with hyponatremia onset

Frontiers in Immunology
ObjectivesThis case report aims to highlight the atypical presentation and management of a patient diagnosed with CASPR2-associated autoimmune encephalitis and NF155 antibody-positive autoimmune nodopathies (AN), initially presenting with limb weakness ...
Wen-Ya Wang, Wen-Ya Wang, Wen-Ya Wang, Jing-Ying Huang, Jing-Ying Huang, Jing-Ying Huang, Ying Xue, Ying Xue, Ying Xue, An-Ran Zhang, An-Ran Zhang, An-Ran Zhang, Ruo-Yi Guo, Ruo-Yi Guo, Ruo-Yi Guo, Zhen Jia, Zhen Jia, Zhen Jia, Ya-Fei Sun, Ya-Fei Sun, Ya-Fei Sun, Bin Li, Bin Li, Bin Li   +23 more
doaj   +1 more source

MOG-AD and CASPR2 Encephalitis (Overlap Syndrome) in an Adolescent Girl: A Case Report

Indian Pediatrics Case Reports
Background: Although myelin oligodendrocytes glycoprotein antibody-associated disease (MOG-AD) and anti-contactin-associated protein-like 2 (CASPR2) antibody-mediated encephalitis are distinct neurological disorders, combined existence has rarely been ...
Dona Teresa Thomas, Davidson Devasia, Jeeson Cheeran Unni, Sudheeran Kannoth, Ranjini Ramachandran   +4 more
doaj   +1 more source

Selective Axonal Expression of the Kv1 Channel Complex in Pre-myelinated GABAergic Hippocampal Neurons

Frontiers in Cellular Neuroscience, 2019
In myelinated fibers, the voltage-gated sodium channels Nav1 are concentrated at the nodal gap to ensure the saltatory propagation of action potentials.
Giulia Bonetto, Bruno Hivert, Laurence Goutebroze, Domna Karagogeos, Valérie Crépel, Catherine Faivre-Sarrailh   +5 more
doaj   +1 more source

Case Report: When multiple system atrophy masquerades as CASPR2 autoimmune encephalopathy: a diagnostic pitfall

Frontiers in Human Neuroscience
IntroductionMultiple system atrophy (MSA) is a sporadic, adult-onset neurodegenerative disorder characterized by rapid progression. Early diagnosis remains particularly challenging, especially when CASPR2 antibodies are detected during the early stages ...
Jun Zhang, Yueming Wang, Le Chen, Jun Li
doaj   +1 more source

Neuronal Antibodies in Children with or without Narcolepsy following H1N1-AS03 Vaccination.

PLoS ONE, 2015
Type 1 narcolepsy is caused by deficiency of hypothalamic orexin/hypocretin. An autoimmune basis is suspected, but no specific antibodies, either causative or as biomarkers, have been identified. However, the AS03 adjuvanted split virion H1N1 (H1N1-AS03)
Simon Thebault, Patrick Waters, Matthew D Snape, Dominic Cottrell, Niklas Darin, Tove Hallböök, Anne Huutoniemi, Markku Partinen, Andrew J Pollard, Angela Vincent   +9 more
doaj   +1 more source

Case report: Recurring potassium channel complex autoimmunity-related neuropathic pain

Frontiers in Immunology
Voltage-gated potassium channel (VGKC) complex autoimmunity associated with nerve hyperexcitability is an uncommon clinical spectrum. It is mostly characterized by limbic encephalitis, continuous neuromyotonia, and dysautonomia. Pain, however, has rarely
Yun-Qing Zhu, Xin-Qiao Zhou, Min Yang, Smita Horill, Zhong-Yun Wang, Jian-Jun Yang, Yin-Bing Pan, Xiao-Kai Zhou   +7 more
doaj   +1 more source

Isaacs Syndrome in A Patient with Positive CASPR2 And LGI1 Antibodies: A Case Report and Literature Review

Case Reports in Clinical Practice
Isaacs Syndrome (IS) is an autoimmune disease characterized by fasciculations, dysautonomia, and hyperactivity of muscle fibers due to hyperexcitability of the peripheral nerve system.
Rasa Zafari, Mona Ahmadi
doaj   +1 more source

Antibody-Dependent Cellular Phagocytosis and Cytotoxicity in Patients With LGI1 and CASPR2 Encephalitis. [PDF]

Neurol Neuroimmunol Neuroinflamm
Businaro P, Masciocchi S, Scaranzin S, Morandi C, Zuliani F, Malvaso A, Cerne D, Barone P, Toriello A, Arbasino C, Cenciarelli S, Volonghi I, Casagrande S, Nassani S, Currò-Dossi M, Micheli S, Fattapposta F, Bisecco A, Leone C, Marchioni E, Franciotta D, Spatola M, Zardini E, Benedetti L, Gastaldi M.   +24 more
europepmc   +1 more source