Synthetic ShK-like Peptide from the Jellyfish Nemopilema nomurai Has Human Voltage-Gated Potassium-Channel-Blocking Activity [PDF]
Marine DrugsWe identified a new human voltage-gated potassium channel blocker, NnK-1, in the jellyfish Nemopilema nomurai based on its genomic information. The gene sequence encoding NnK-1 contains 5408 base pairs, with five introns and six exons.
Ye-Ji Kim +8 more
doaj +2 more sources
Predicting the functional effects of voltage-gated potassium channel missense variants with multi-task learning [PDF]
EBioMedicine, 2022 Summary: Background: Variants in genes encoding voltage-gated potassium channels are associated with a broad spectrum of neurological diseases including epilepsy, ataxia, and intellectual disability.
Christian Malte Boßelmann +7 more
doaj +2 more sources
Functional reconstitution of a voltage-gated potassium channel in giant unilamellar vesicles. [PDF]
PLoS ONE, 2011 Voltage-gated ion channels are key players in cellular excitability. Recent studies suggest that their behavior can depend strongly on the membrane lipid composition and physical state. In vivo studies of membrane/channel and channel/channel interactions
Sophie Aimon +5 more
doaj +1 more source
Modeling the kinetics of heteromeric potassium channels
Frontiers in Cellular Neuroscience, 2022 Mechanistic mathematical modeling has long been used as a tool for answering questions in cellular physiology. To mathematically describe cellular processes such as cell excitability, volume regulation, neurotransmitter release, and hormone secretion ...
Kees McGahan, James Keener
doaj +1 more source
Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel
Nature Communications, 2023 Human Eag2 is a voltage-gated potassium channel with unique delayed rectifying gating kinetics. Here, authors show how voltage opens the channel and illuminate a mechanism of delayed rectifier gating.
Mingfeng Zhang +2 more
doaj +1 more source
Frontiers in Physiology, 2021 Cardiac arrhythmias significantly contribute to cardiovascular morbidity and mortality. The rabbit heart serves as an accepted model system for studying cardiac cell excitation and arrhythmogenicity.
Anatoli Y. Kabakov +9 more
doaj +1 more source
VKCDB: Voltage-gated potassium channel database
BMC Bioinformatics, 2004 Background The family of voltage-gated potassium channels comprises a functionally diverse group of membrane proteins. They help maintain and regulate the potassium ion-based component of the membrane potential and are thus central to many critical ...
Gallin Warren J, Li Bin
doaj +1 more source
Artificial modulation of the gating behavior of a K+ channel in a KvAP-DNA chimera. [PDF]
PLoS ONE, 2011 We present experiments where the gating behavior of a voltage-gated ion channel is modulated by artificial ligand binding. We construct a channel-DNA chimera with the KvAP potassium channel reconstituted in an artificial membrane.
Andrew Wang, Giovanni Zocchi
doaj +1 more source
Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state
eLife, 2020 Voltage-gated ion channels feature voltage sensor domains (VSDs) that exist in three distinct conformations during activation: resting, intermediate, and activated.
Keenan C Taylor +14 more
doaj +1 more source
Solution NMR of MPS-1 reveals a random coil cytosolic domain structure. [PDF]
PLoS ONE, 2014 Caenorhabditis elegans MPS1 is a single transmembrane helical auxiliary subunit that co-localizes with the voltage-gated potassium channel KVS1 in the nematode nervous system.
Pan Li +7 more
doaj +1 more source