Results 121 to 130 of about 67,507 (290)

EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor [PDF]

open access: yes, 2017
ACKNOWLEDGEMENTS We thank J. M. Valverde (IRB) as well as the NMR facilities of the University of Barcelona (CCiT UB) and the Instituto de Química Física Rocasolano (IQFR, CSIC) for their assistance in, respectively, protein production and NMR. This work
Bertoncini, Carlos W.   +12 more
core   +2 more sources

Identification of genetically predicted protein biomarkers and drug targets for prostate cancer via Mendelian randomization

open access: yesVIEW, EarlyView.
Prostate cancer, a leading cause of cancer in men globally, urgently requires improved diagnostic and treatment strategies. This study analyzed large genetic datasets and identified five key proteins (THBD, DST, IFI27L2, OSBPL10, PPP1R14A) that either increase or decrease cancer risk, while also exploring their roles in immune response and potential ...
Maoping Cai   +11 more
wiley   +1 more source

Queering Institutional Milestones in Elite Higher Education: Queer Perspectives on Princeton University and Coeducation (1960–1980)

open access: yesGender &History, EarlyView.
ABSTRACT A new archive of oral history interviews from LGBTQIA‐identified alumni, faculty and staff reveals the complex ways that queer and transgender students understood, experienced and remembered the long transition from single‐sex to coeducation at Princeton University.
Ezelle Sanford III   +2 more
wiley   +1 more source

Cuttings, Combings, Fettlings and Flock: Gender and Australian Wool ‘Waste’, 1900–1950

open access: yesGender &History, EarlyView.
ABSTRACT As Australia's wool industry produced vast amounts of fine fleece from the nineteenth century, the wool processing and clothes manufacturing industries generated waste – products like cuttings, combings, fettlings and flock. Salvaged and then sold to waste merchants, these and other materials had a second life.
Lorinda Cramer
wiley   +1 more source

Histone Deacetylase Inhibitors Restore Cell Surface Expression of the Coxsackie Adenovirus Receptor and Enhance CMV Promoter Activity in Castration-Resistant Prostate Cancer Cells

open access: yesProstate Cancer, 2012
Adenoviral gene therapy using the death receptor ligand TRAIL as the therapeutic transgene can be safely administered via intraprostatic injection but has not been evaluated for efficacy in patients.
Laura Kasman   +2 more
doaj   +1 more source

‘The Bethune College Sensation’: Gender, Archive and Radical Passivity

open access: yesGender &History, EarlyView.
ABSTRACT This article explores the student protests at Bethune College, Calcutta, on 3 February 1928, against the Simon Commission, a British parliamentary delegation that excluded Indian representation. On this day, female students staged a quiet but radical act of defiance by refusing to attend classes, sign apologies or vacate their hostel, despite ...
Meghmala Bhattacharya
wiley   +1 more source

Unravelling Evolutionary Dynamics of Female Sexual Cannibalism and Male Reproductive Strategies in Spiders

open access: yesIntegrative Zoology, EarlyView.
Sexual cannibalism (SC), where one mating partner consumes the other in the context of mating, is especially prevalent among spiders. However, the evolution of SC in spiders is still not fully understood. We review key hypotheses for SC and explore how female‐initiated SC has driven the evolution of various male counter‐adaptations to mitigate its ...
Simona Kralj‐Fišer   +3 more
wiley   +1 more source

Utility of SUVmax on Primary Staging 68Ga‐PSMA PET in Determining Metastatic Status of Prostate Cancer

open access: yesJournal of Medical Imaging and Radiation Oncology, EarlyView.
ABSTRACT Introduction 68Ga prostate‐specific membrane antigen (PSMA) has been shown to have prognostic value in detecting PSMA expressing metastasis from prostate cancer, but inevitably, there are cases in which suspected metastases demonstrate equivocal uptake.
Geoffrey Liu, Shane Lee, Kabir Ahmad
wiley   +1 more source

Cost-effectiveness analyses and cost analyses in castration-resistant prostate cancer: A systematic review.

open access: yesPLoS ONE, 2018
BackgroundTreatment of metastatic prostate cancer is associated with high personal and economic burden. Recently, new treatment options for castration-resistant prostate cancer became available with promising survival advantages.
Thomas Grochtdreis   +4 more
doaj   +1 more source

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