Results 91 to 100 of about 229,451 (392)

Therapeutic Targeting of BET Bromodomain Proteins in Castration-Resistant Prostate Cancer

Nature, 2014
Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. Progression to CRPC after androgen ablation therapy is predominantly driven by deregulated androgen receptor (AR) signalling. Despite the success of
I. Asangani, Vijaya L. Dommeti, Xiaoju Wang, Rohit Malik, M. Cieslik, Rendong Yang, J. Escara-Wilke, K. Wilder-Romans, Sudheer Dhanireddy, Carl G. Engelke, Mathew K. Iyer, Xiaojun Jing, Yi-Mi Wu, Xuhong Cao, Zhaohui S. Qin, Shaomeng Wang, F. Feng, A. Chinnaiyan   +17 more
semanticscholar   +1 more source

Heterogeneity Landscape of Circulating Tumor Cells in Clinical Utility

Advanced Therapeutics, EarlyView.
This study reports the heterogeneity spectrum of circulating tumor cells. The factors involved in the spectrum promote CTCs to overcome barriers in the metastatic cascade but impact the clinical outcome of cancer patients. In summary, the heterogeneities in association with CTCs ultimately reduce patient survival and facilitate increasing mortality of ...
Md Kowsar Alam, Lu Yanjun, Bee Luan Khoo, Tongxu Si, Heng Zou, Mengsu Yang   +5 more
wiley   +1 more source

Beyond the immune suppression: the immunotherapy in prostate cancer [PDF]

, 2015
Prostate cancer (PCa) is the second most common cancer in men.Aswell in many other human cancers, inflammation and immune suppression have an important role in their development.We briefly describe the host components that interact with the tumor to ...
Agliano', Anna Maria, Cattarino, Susanna, Collalti, Giulia, Sciarra, Alessandro, Silvestri, Ida   +4 more
core   +3 more sources

Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5

Advanced Science, EarlyView.
Okanin suppresses colorectal cancer growth by directly targeting PRDX5. This natural compound selectively binds peroxiredoxin 5 (PRDX5), inhibiting its activity and inducing WSB1‐mediated degradation. PRDX5 loss elevates ROS, suppresses GPX4 via SIAH2, and further triggers cell death (apoptosis and ferroptosis).
Ji Zhong Zhao, Yuan Fei Li, Fu Kang Yuan, Meng Lu Zhao, Ya Wen Han, Jia Xin Wang, Qi Yang, Han Ying Ye, Yu Cheng Lu, Shao Chin Lee   +9 more
wiley   +1 more source

Economics of boar taint prevention without surgical castration in the pork chain [PDF]

, 2010
An economic analyses of boar taint prevention without surgical castration is lacking. This paper explores currently feasible alternatives to surgical castration along the pork chain.
Backus, G.B.C., Hoste, R., Smet, A., de, Valeeva, N.I.   +3 more
core   +1 more source

Osteoblast‐CD4+ CTL Crosstalk Mediated by SIRT1/DAAM2 Axis Prevents Age‐Related Bone Loss

Advanced Science, EarlyView.
In the osteoblastic niche, SIRT1 activates and recruits CD4+ CTLs by increasing DAAM2 expression via EZH2 deacetylation and boosting the secretion of key chemokines, such as CCL3, CCL5, and CXCL10. Then, CD4+ CTL directly eliminates senescent osteoblasts in an MHC‐II‐dependent way, thereby slowing down the process of bone ageing and effectively ...
Bin Yang, Guofu Zhang, Yizhou Zhu, Jingcheng Wang, Xinmin Feng, Wenyong Fei, Jihang Dai, Le Hu, Yi Zhang, Jun Cai, Binjia Ruan, Yue Jin, Fanhao Wei, Gang Lu, Dongan Wang, Jason Pui Yin Cheung, Graham Ka Hon Shea, Hao Chen, Kelvin Wai Kwok Yeung, Lei Wang, Yongxiang Wang   +20 more
wiley   +1 more source

Male animal sterilization: history, current practices, and potential methods for replacing castration

Frontiers in Veterinary Science
Sterilization and castration have been synonyms for thousands of years. Making an animal sterile meant to render them incapable of producing offspring.
Rex A. Hess, Rex A. Hess, Chan Jin Park, Chan Jin Park, Sandra Soto, Lindsey Reinacher, Ji-Eun Oh, Mary Bunnell, CheMyong J. Ko, CheMyong J. Ko   +9 more
doaj   +1 more source

Effect of horse sex status on British Eventing competition performance: an observational study between 1998 and 2016 [PDF]

, 2018
To test the hypothesis that gender affects horse scores in eventing competition, data on the scores and points awarded to 681 horses was collected from the British Eventing website.
Fouladi-Nashta, A A, Hanousek, K, Salavati, M   +2 more
core   +1 more source

A novel AR translational regulator lncRNA LBCS inhibits castration resistance of prostate cancer

Molecular Cancer, 2019
Progression to a castration resistance state is the main cause of deaths in prostate cancer (PCa) patients. Androgen Receptor (AR) signaling plays the central role in progression of Castration Resistant Prostate Cancer (CRPC), therefore understanding the
Peng Gu, Xu Chen, Ruihui Xie, Weibin Xie, Li Huang, W. Dong*, Jinli Han, Xiaodong Liu, Ji-hong Shen, Jian Huang, Tianxin Lin   +10 more
semanticscholar   +1 more source

A Novel Cultivation System for Germ Cell Proliferation and Sustaining Whole Testicular Niche

Advanced Science, EarlyView.
A hydrogel microneedle‐based system enables whole testicular cultivation, supporting spermatogonial proliferation and enhancing spermatogenesis in vitro. This ‘whole testicular spermatogonia pool’ (WTSP) significantly increases spermatid production and fertility potential in mice. This system also promotes spermatogonial expansion in human fetal testes,
Yu Xia, Xiaoxuan Zhang, Bohang Zhang, Minhui Lu, Qing Cheng, Li Liu, Lifang Shi, Yiqiang Cui, Dingdong Chen, Laihua Li, Xuejiang Guo, Jingtao Guo, Jiahao Sha, Yuanjin Zhao, Yan Yuan   +14 more
wiley   +1 more source