Results 131 to 140 of about 219,417 (396)

Effect of a topical anaesthetic formulation on the cortisol response to surgical castration of unweaned beef calves

Animal, 2016
Impracticality and cost of existing pain management strategies during surgical castration of beef cattle have limited their widespread implementation on-farm. A farmer-applied topical anaesthetic formulation, originally developed and used commercially to
D. McCarthy, S. Lomax, P.A. Windsor, P.J. White   +3 more
doaj  

A perversão, o desejo e o gozo: articulações possíveis

Estudos de Psicologia (Campinas)
Os autores procuram subsidiar aportes para uma discussão acerca da especificidade estrutural da perversão e sua relação com o desejo e com o gozo. Circunscrever o campo da perversão a partir de sua etiologia, delimitar os processos metapsicológicos ...
Adelson Bruno dos Reis Santos, Vera Lopes Besset   +1 more
doaj   +1 more source

Real-world outcomes of sipuleucel-T treatment in PROCEED, a prospective registry of men with metastatic castration-resistant prostate cancer. [PDF]

, 2019
BackgroundThe large registry, PROVENGE Registry for the Observation, Collection, and Evaluation of Experience Data (PROCEED)(NCT01306890), evaluated sipuleucel-T immunotherapy for asymptomatic/minimally symptomatic metastatic castration-resistant ...
Armstrong, Andrew J, Chang, Nancy N, Concepcion, Raoul S, Cooperberg, Matthew R, Harmon, Matt, Higano, Celestia S, Kantoff, Philip W, Kassabian, Vahan, McLeod, David G, Nordquist, Luke T, Penson, David F, Pieczonka, Christopher M, Quinn, David I, Sartor, A Oliver, Scholz, Mark C, Shore, Neal D, Tang, Hong, Tutrone, Ronald F, Tyler, Robert C, Vacirca, Jeffrey, Vogelzang, Nicholas J   +20 more
core   +2 more sources

Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth.

Cancer Research, 2008
Therapy for advanced prostate cancer centers on suppressing systemic androgens and blocking activation of the androgen receptor (AR). Despite anorchid serum androgen levels, nearly all patients develop castration-resistant disease.
R. Montgomery, E. Mostaghel, R. Vessella, D. Hess, T. Kalhorn, C. Higano, L. True, P. Nelson   +7 more
semanticscholar   +1 more source

Potential sensitivity of pork production situations aiming at high-quality products to the use of entire male pigs as an alternative to surgical castrates

Animal, 2018
The perspective of a possible ban on surgical castration of male pigs in the EU is a real challenge for pork production systems aiming at (very) high-quality products.
M. Bonneau, M. Čandek-Potokar, M. Škrlep, M. Font-i-Furnols, M. Aluwé, L. Fontanesi   +5 more
doaj  

Practical recommendations for radium-223 treatment of metastatic castration-resistant prostate cancer [PDF]

, 2017
is the first targeted alpha therapy for patients with castration resistant prostate cancer and symptomatic bone metastases. Radium-223 provides a new treatment option for this setting, but also necessitates a new treatment management approach.
Carrió, Ignasi, De Vincentis, Giuseppe, Du, Yong, Fanti, Stefano, Ilhan, Harun, Lewington, Val, Mommsen, Caroline, Nitzsche, Egbert, Oyen, Wim, Sundram, Francis, Universitat Autònoma de Barcelona, Vogel, Wouter   +11 more
core   +4 more sources

Castration-mediated IL-8 Promotes Myeloid Infiltration and Prostate Cancer Progression

bioRxiv, 2019
Immunotherapy is a treatment for many types of cancer, primarily due to deep and durable clinical responses mediated by immune checkpoint blockade (ICB)1, 2. Prostate cancer is a notable exception in that it is generally unresponsive to ICB. The standard
Zoila A. Lopez-Bujanda, Michael C. Haffner, M. Chaimowitz, Nivedita Chowdhury, Nicholas J. Venturini, A. Obradović, C. Hansen, J. Jacków, K. Sfanos, C. Bieberich, P. Hurley, M. Selby, A. Korman, A. Christiano, A. D. De Marzo, C. Drake   +15 more
semanticscholar   +1 more source

A comparison of generalized multinomial logit, random parameters logit, wtp-space and latent class models to studying consumers' preferences for animal welfare [PDF]

, 2016
The European societies are requiring that animals to be raised as closely as possible to their natural conditions. The growing concerns about animal welfare is resulting in continuous modifications of regulations and policies that led to ban of a number ...
Borrisser-Pairó,, Francesc, Gil Roig, José María, Kallas, Zein, Martínez, Beatriz, Olivar, Maria Angels, Panella-Riera, Nuria, Vieira, Ceferina   +6 more
core  

PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial

Nature Network Boston, 2022
V. Narayan, J. Barber-Rotenberg, In-Young Jung, S. Lacey, A. Rech, M. Davis, W. Hwang, P. Lal, E. Carpenter, S. Maude, G. Plesa, N. Vapiwala, A. Chew, Michael Moniak, R. Sebro, M. Farwell, A. Marshall, J. Gilmore, Lester Lledo, Karen Dengel, S. Church, Tyler D. Hether, Junnnan Xu, M. Gohil, Thomas H. Buckingham, S. Yee, V. Gonzalez, I. Kulikovskaya, Fang Chen, Lifeng Tian, Kyle Tien, W. Gladney, Christopher L. Nobles, H. Raymond, Diane Mary Elizabeth Holly Jonathan Samantha Sophia Juli Frazee Truran Veloso McConville Aguedelo Hower Ngo, D. Frazee, Mary Truran, E. Veloso, Holly McConville, Jonathan Aguedelo, S. Hower, Sophia Ngo, J. Jadlowsky, J. Melenhorst, A. Roche, J. Everett, Minnal Gupta, Farzana Nazimuddin, C. Bartoszek, Natalka Koterba, R. Reynolds, F. Ellington, Christopher C. Kloss, Jihyun Lee, Yangbing Zhao, J. Scholler, J. Riley, Christina Bailey, A. White, Briana M. Hudson, Pearl S Chang, M. Maus, B. Levine, E. Hexner, D. Siegel, F. Bushman, C. June, J. Fraietta, N. Haas   +68 more
semanticscholar   +1 more source

Breaking barriers: Smart vaccine platforms for cancer immunomodulation

Cancer Communications, EarlyView.
Abstract Despite significant advancements in cancer treatment, current therapies often fail to completely eradicate malignant cells. This shortfall underscores the urgent need to explore alternative approaches such as cancer vaccines. Leveraging the immune system's natural ability to target and kill cancer cells holds great therapeutic potential ...
Mohammad Mahmoudi Gomari, Taha Ghantabpour, Nima Pourgholam, Neda Rostami, Stephen M. Hatfield, Farzaneh Namazifar, Shadi Abkhiz, Seyed Sadegh Eslami, Mahsa Ramezanpour, Mahsa Darestanifarahani, Igor Astsaturov, Sidi A. Bencherif    +11 more
wiley   +1 more source