Results 11 to 20 of about 229,451 (392)

Identification of the α2 chain of interleukin‐13 receptor as a potential biomarker for predicting castration resistance of prostate cancer using patient‐derived xenograft models

Cancer Reports, 2023
Background Several treatment strategies use upfront chemotherapy or androgen receptor axis‐targeting therapies for metastatic prostate cancer. However, there are no useful biomarkers for selecting appropriate patients who urgently require these ...
Takahiro Nagai, Naoki Terada, Masato Fujii, Yasuhisa Nagata, Kozue Nakahara, Shoichiro Mukai, Kosuke Okasho, Yuki Kamiyama, Shusuke Akamatsu, Takashi Kobayashi, Kei Iida, Masatsugu Denawa, Masatoshi Hagiwara, Takahiro Inoue, Osamu Ogawa, Toshiyuki Kamoto   +15 more
doaj   +1 more source

Testosterone Metabolite 6β‐Hydroxytestosterone Contributes to Angiotensin II‐Induced Abdominal Aortic Aneurysms in Apoe–/– Male Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Sex is a prominent risk factor for abdominal aortic aneurysms (AAAs), and angiotensin II (Ang II) induces AAA formation to a greater degree in male than in female mice.
Kamalika Mukherjee, Ajeeth K. Pingili, Purnima Singh, Ahmad N. Dhodi, Shubha R. Dutta, Frank J. Gonzalez, Kafait U. Malik   +6 more
doaj   +1 more source

Oral ethinylestradiol in castration resistent prostate cancer: 10 year experience [PDF]

, 2015
To describe our 10-year experience with the use of oral ethinylestradiol in the treatment of metastatic castration-resistant prostate cancer. METHODS: From February 2000 to April 2010, 116 patients with a metastatic castration-resistant prostate cancer
Aggarwal, Beer, Bonkhoff, Bono, Chadha, Corey, Di Silverio, Gasent Blesa, Izumi, Kitahara, Limonta, Montgomery, Shamash, Stein, Takezawa, Tannock, Wilkins   +16 more
core   +1 more source

Measurement of Fecal Testosterone Metabolites in Mice: Replacement of Invasive Techniques [PDF]

, 2020
Testosterone is the main reproductive hormone in male vertebrates and conventional methods to measure testosterone rely on invasive blood sampling procedures.
Auer, Kerstin E., Hohlbaum, Katharina, Kußmaul, Marius, Möstl, Erich, Palme, Rupert, Rülicke, Thomas   +5 more
core   +1 more source

Optimal Methods of Documenting Analgesic Efficacy in Neonatal Piglets Undergoing Castration

Animals, 2020
Analgesic products for piglet castration are critically needed. This requires extensive animal experimentation such as to meet regulatory-required proof of efficacy. At present, there are no validated methods of assessing pain in neonatal piglets.
Meredith Sheil, Adam Polkinghorne
doaj   +1 more source

A Phase I Study of Abiraterone Acetate Combined with BEZ235, a Dual PI3K/mTOR Inhibitor, in Metastatic Castration Resistant Prostate Cancer. [PDF]

, 2017
Lessons learnedThe combination of standard dose abiraterone acetate and BEZ235, a pan-class I PI3K and mTORC1/2 inhibitor, was poorly tolerated in men with progressive mCRPC.Although the clinical development of BEZ235 has been discontinued in prostate ...
Friedlander, Terence, Hsieh, Andrew C, Kim, Won, Lin, Amy M, Louttit, Mirela, Ryan, Charles J, Wei, Xiao X   +6 more
core   +1 more source

Survival with Olaparib in Metastatic Castration-Resistant Prostate Cancer.

New England Journal of Medicine, 2020
BACKGROUND We previously reported that olaparib led to significantly longer imaging-based progression-free survival than the physician's choice of enzalutamide or abiraterone among men with metastatic castration-resistant prostate cancer who had ...
M. Hussain, J. Mateo, K. Fizazi, F. Saad, N. Shore, S. Sandhu, K. Chi, O. Sartor, N. Agarwal, D. Olmos, A. Thiery-Vuillemin, P. Twardowski, G. Roubaud, M. Özgüroğlu, Jinyu Kang, J. Burgents, C. Gresty, C. Corcoran, C. Adelman, J. D. de Bono   +19 more
semanticscholar   +1 more source

Responsible ownership for cats and dogs from different urban neighborhoods of the City of Umuarama, Paraná, Brazill

Brazilian Journal of Veterinary Medicine, 2020
The article analyzed the responsible care and well-being of dogs and cats of different districts of the municipality of Umuarama, PR. We interviewed 53 tutors by means of a directed questionnaire, obtaining 106 animals evaluated indirectly.
Thaís Camaso de Sá, Jessé Lahos Borges, Ana Maria Quessada, Antônio Sérgio Ferraudo, Eduardo Herrera Dias, Marco Aurélio Cunha del Vechio, Pollyana Linhares Sala, Mayara da Silva Trentim, Luciana Kazue Otutumi   +8 more
doaj   +1 more source

Sugarcane bagasse or elephant grass hay in diets for goats: Performance, feeding behavior and carcass characteristics

Revista Colombiana de Ciencias Pecuarias, 2021
Background: Novel feeding strategies should be developed to produce high-quality meat in current goat production systems. Objective: To evaluate the effects of castration and the association of spineless cactus with sugarcane bagasse or elephant grass ...
Victor H. Campelo-Lima, Stela Antas-Urbano, Marcelo Andrade-Ferreira, Pedro H. Cavalcante-Ribeiro, José I. Gomes-Bezerra, Juana C. Cariri-Chagas, Emerson Moreira-Aguiar, Adriano H. Nascimento-Rangel   +7 more
doaj   +1 more source

The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of prostate carcinoma. [PDF]

, 2016
Prostate cancer is the most commonly diagnosed malignancy and second leading cause of cancer death among men in the United States. In recent years, several new agents, including cancer immunotherapies, have been approved or are currently being ...
Bander, Neil H, Beer, Tomasz M, Drake, Charles G, Fong, Lawrence, Gulley, James L, Harrelson, Stacey, Kantoff, Philip W, Madan, Ravi A, McNeel, Douglas G, Oh, William K, Peace, David J, Petrylak, Daniel P, Porterfield, Hank, Sartor, Oliver, Shore, Neal D, Slovin, Susan F, Stein, Mark N, Vieweg, Johannes   +17 more
core   +1 more source