Results 11 to 20 of about 83,207 (290)

ADAMTS9‐AS2 Disrupts Docetaxel‐Resistance in Castration‐Resistant Prostate Cancer via Stemness Suppression and Ferroptosis Induction [PDF]

Advanced Science, EarlyView.
This study uncovered a dual‐track mechanism by which ADAMTS9‐AS2 overcame chemoresistance in CRPC: suppressing cancer stemness through the FOXF2/TGF‐β2 pathway, and triggering ferroptosis via competitive SLC7A11 sequestration. Polymeric materials co‐targeting these vulnerabilities further boost docetaxel sensitivity, highlighting a compelling strategy ...
Ji Liu, Yan Gao, Yadong Guo, Junfeng Zhang, Wentao Zhang, Zhuoran Gu, Haotian Chen, Chengqi Jin, Peng Luo, Shiyu Mao, Yajuan Hao, Shuo Shi, Xudong Yao   +12 more
openalex   +2 more sources

Testosterone Metabolite 6β‐Hydroxytestosterone Contributes to Angiotensin II‐Induced Abdominal Aortic Aneurysms in Apoe–/– Male Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Sex is a prominent risk factor for abdominal aortic aneurysms (AAAs), and angiotensin II (Ang II) induces AAA formation to a greater degree in male than in female mice.
Kamalika Mukherjee, Ajeeth K. Pingili, Purnima Singh, Ahmad N. Dhodi, Shubha R. Dutta, Frank J. Gonzalez, Kafait U. Malik   +6 more
doaj   +1 more source

Pengaruh kastrasi terhadap performan produksi Sapi Persilangan Wagyu berdasarkan umur yang berbeda

Jurnal Ilmu-Ilmu Peternakan, 2016
The purpose of this research was to know the effect of castration to Wagyu crossbreed cattle production performance based on age difference and know the appropriate age to do castration.
Kuswati Kuswati, Ravenska Ravenska, Nareswara Hapsari, Aulia Puspita Anugra Yekti, Trinil Susilawati   +4 more
doaj   +1 more source

Physiology and behavior of pigs before and after castration: effects of two topical anesthetics

Animal, 2010
Surgical castration of male piglets is a common management practice conducted on commercial swine farms to prevent the occurrence of boar taint and aggressive behavior.
M.A. Sutherland, B.L. Davis, T.A. Brooks, J.J. McGlone   +3 more
doaj   +1 more source

Optimal Methods of Documenting Analgesic Efficacy in Neonatal Piglets Undergoing Castration

Animals, 2020
Analgesic products for piglet castration are critically needed. This requires extensive animal experimentation such as to meet regulatory-required proof of efficacy. At present, there are no validated methods of assessing pain in neonatal piglets.
Meredith Sheil, Adam Polkinghorne
doaj   +1 more source

Feasibility of pre-scrotal castration approach in boars: 30 cases

Pesquisa Veterinária Brasileira, 2023
: Since the first reports of boar castration, the anesthesia, surgery, and especially the restraint for surgical wound management of large and strong boars may be challenging.
Antônio Carlos L. Câmara, Kaique Nogueira, João Vagner S. Junqueira, Tiago S. Andrade, Antonio Raphael Teixeira-Neto, Rita de Cássia Campebell   +5 more
doaj   +1 more source

Effect of Lignocaine and a Topical Vapocoolant Spray on Pain Response during Surgical Castration of Beef Calves

Animals, 2019
This study assessed the efficacy of pre-operative injected lignocaine and peri-operative topical vapocoolant spray, administered as most practical for incorporation into routine calf castration procedures.
Dominique Van der Saag, Sabrina Lomax, Peter Andrew Windsor, Evelyn Hall, Peter John White   +4 more
doaj   +1 more source

Acute physiological responses to castration-related pain in piglets: the effect of two local anesthetics with or without meloxicam

Animal, 2016
Methods to reduce castration-related pain in piglets are still issues of concern and interest for authorities and producers. Our objectives were to estimate the effectiveness of two protocols of local anesthesia (lidocaine and the combination of ...
C. Bonastre, O. Mitjana, M.T. Tejedor, M. Calavia, A.G. Yuste, J.L. Úbeda, M.V. Falceto   +6 more
doaj   +1 more source

The Polemic on Imposing Castration Sanctions against Pedophiles Perpetrators Based on the Human Right’s Perspective

Constitutionale, 2021
Sexual violence is a crime against humanity. Because, it is, closely related to human rights Cases of sexual violence caused the government to issue the idea of castration for perpetrators of sexual violence.
Rakhmat Ubaidillah Ahror
doaj   +1 more source

Total Intravenous Anaesthesia with Ketamine, Medetomidine and Midazolam as Part of a Balanced Anaesthesia Technique in Horses Undergoing Castration

Veterinary Sciences, 2021
To evaluate the use of ketamine-medetomidine-midazolam total intravenous infusion as part of a balanced anaesthetic technique for surgical castration in horses. Five healthy Standardbred cross colts were premedicated with IV acepromazine (0.01–0.02 mg/kg)
Alexandra Cunneen, Shaun Pratt, Nigel Perkins, Margaret McEwen, Geoffrey Truchetti, Joanne Rainger, Trish Farry, Lisa Kidd, Wendy Goodwin   +8 more
doaj   +1 more source