Results 51 to 60 of about 174,818 (337)
Advanced Science, EarlyView.Castration‐resistant prostate cancer (CRPC) remains sensitive to ferroptosis, but its intrinsic resistance is poorly understood. Here, we identify NFIB as a master suppressor. SIRT7‐mediated NFIB acetylation drives its liquid–liquid phase separation, which promotes SLC3A2 transcription to inhibit ferroptosis.
Qiunuo Li +11 more
wiley +1 more source
Renal phenotype of Et-1 transgenic mice is modulated by androgens
European Journal of Medical Research, 2009 Introduction Activation of the endothelin (ET) system promotes inflammation and fibrosis in various tissues including the kidney. Male ET-1 transgenic mice are characterized by chronic kidney inflammation and renal scarring.
Kalk P +6 more
doaj +1 more source
Current Advances of Nitric Oxide in Cancer and Anticancer Therapeutics
Vaccines, 2021 Nitric oxide (NO) is a short-lived, ubiquitous signaling molecule that affects numerous critical functions in the body. There are markedly conflicting findings in the literature regarding the bimodal effects of NO in carcinogenesis and tumor progression,
Joel Mintz +7 more
doaj +1 more source
Ban on castration of boars in the Netherlands: modeling economic consequences of options [PDF]
, 2009 As a result of social criticism on castration, the Netherlands intend to start fattening boars. The great obstacle to a ban on castration is the expected negative effect on international trade because of the fear of boar taint.
Backus, G.B.C. +2 more
core +1 more source
Towards entire male pigs in Europe: a perspective from the Spanish supply chain [PDF]
, 2016 In pig production, surgical castration is primarily performed to avoid boar taint and for management purposes. The European Commission plans to end surgical piglet castration voluntarily by 2018.
Avena, Maria +7 more
core +2 more sources
Advanced Science, EarlyView.GNL3 is a novel AR coregulator with dual coactivator and corepressor functions in prostate cancer (PCa). Our study uncovers a previously unrecognized mechanism by which the AR transcriptional complex integrates oncogenic signaling and immune suppression.
Cuiting Zhang +12 more
wiley +1 more source
Jurnal Urologi Indonesia, 2014 Objectives: To demonstrate that intratesticular injection of 20% hypertonic sodium chloride can result in permanent castration and to evaluate serum changes in sodium chloride levels.
Marta Hendry +5 more
doaj +1 more source
ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. [PDF]
, 2016 The androgen receptor (AR) is overexpressed and hyperactivated in human castration-resistant prostate cancer (CRPC). However, the determinants of AR overexpression in CRPC are poorly defined.
Borowsky, Alexander D +17 more
core +2 more sources
Multimodal Cross‐Attentive Graph‐Based Framework for Predicting In Vivo Endocrine Disruptors
Advanced Science, EarlyView.A multimodal cross‐attentive graph neural network integrates molecular graphs with androgen and estrogen adverse outcome pathway (AOP)–anchored in vitro assay signals to predict in vivo endocrine disruption. By fusing information on Tier‐1 AOP logits with chemical structures, the framework achieves high accuracy and provides assay‐traceable ...
Eder Soares de Almeida Santos +6 more
wiley +1 more source
A comparison of generalized multinomial logit, random parameters logit, wtp-space and latent class models to studying consumers' preferences for animal welfare [PDF]
, 2016 The European societies are requiring that animals to be raised as closely as possible to their natural conditions. The growing concerns about animal welfare is resulting in continuous modifications of regulations and policies that led to ban of a number ...
Borrisser-Pairó,, Francesc +6 more
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