Results 51 to 60 of about 229,451 (392)
British Journal of Pharmacology, 2020 Prostate cancer is the second most common malignancy in men and androgen deprivation therapy is the first‐line therapy. However, most cases will eventually develop castration‐resistant prostate cancer after androgen deprivation therapy treatment ...
Yuanyuan Wang +6 more
semanticscholar +1 more source
The World Journal of Men's Health, 2023 Purpose: To analyze the variability, associated actors, and the design of nomograms for individualized testosterone recovery after cessation of androgen deprivation therapy (ADT).
Ángel Borque-Fernando +4 more
doaj +1 more source
Castration of a hermaphrodite [PDF]
Journal of Comparative Pathology and Therapeutics, 1899 n ...
openaire +3 more sources
Effective Combinatorial Immunotherapy for Castration Resistant Prostate Cancer
Nature, 2017 A significant fraction of patients with advanced prostate cancer treated with androgen deprivation therapy experience relapse with relentless progression to lethal metastatic castration-resistant prostate cancer (mCRPC).
Xin Lu +13 more
semanticscholar +1 more source
Rapid, ultra low coverage copy number profiling of cell-free DNA as a precision oncology screening strategy. [PDF]
, 2017 Current cell-free DNA (cfDNA) next generation sequencing (NGS) precision oncology workflows are typically limited to targeted and/or disease-specific applications.
Alva, Ajjai S +31 more
core +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Collection, storage and freezability of equine epididymal spermatozoa
Italian Journal of Animal Science, 2016 The recovery of spermatozoa from the cauda epididymis may be the last chance to obtain genetic material from stallions undergone to castration. The aim of the current study was to evaluate the efficiency of cryopreservation and the use of two different ...
Maria Elena Falomo +2 more
doaj +1 more source
Genomics of lethal prostate cancer at diagnosis and castration resistance
Journal of Clinical Investigation, 2019 The genomics of primary prostate cancer differ from those of metastatic castration-resistant prostate cancer (mCRPC). We studied genomic aberrations in primary prostate cancer biopsies from patients who developed mCRPC, also studying matching, same ...
J. Mateo +34 more
semanticscholar +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source