Results 1 to 10 of about 38 (38)

The Role of Regulator Catabolite Control Protein A (CcpA) in Streptococcus agalactiae Physiology and Stress Response

open access: yesMicrobiology Spectrum, 2022
Streptococcus agalactiae is a leading cause of infections in neonates. This opportunistic pathogen colonizes the vagina, where it has to cope with acidic pH and hydrogen peroxide produced by lactobacilli.
Anne-Emmanuelle Roux   +7 more
doaj   +1 more source

CcpA Regulates Staphylococcus aureus Biofilm Formation through Direct Repression of Staphylokinase Expression

open access: yesAntibiotics, 2022
Staphylococcus aureus represents a notorious opportunistic pathogen causing various infections in biofilm nature, imposing remarkable therapeutic challenges worldwide.
Mingxia Zheng   +9 more
doaj   +1 more source

comCDE (Competence) Operon Is Regulated by CcpA in Streptococcus pneumoniae D39

open access: yesMicrobiology Spectrum, 2023
Natural transformation plays an important role in the formation of drug-resistant bacteria. Exploring the regulatory mechanism of natural transformation can aid the discovery of new antibacterial targets and reduce the emergence of drug-resistant ...
Yapeng Zhang   +8 more
doaj   +1 more source

Impact of the Histidine-Containing Phosphocarrier Protein HPr on Carbon Metabolism and Virulence in Staphylococcus aureus

open access: yesMicroorganisms, 2021
Carbon catabolite repression (CCR) is a common mechanism pathogenic bacteria use to link central metabolism with virulence factor synthesis. In gram-positive bacteria, catabolite control protein A (CcpA) and the histidine-containing phosphocarrier ...
Linda Pätzold   +6 more
doaj   +1 more source

Ribozyme-Mediated Downregulation Uncovers DNA Integrity Scanning Protein A (DisA) as a Solventogenesis Determinant in Clostridium beijerinckii

open access: yesFrontiers in Bioengineering and Biotechnology, 2021
Carbon catabolite repression (CCR) limits microbial utilization of lignocellulose-derived pentoses. To relieve CCR in Clostridium beijerinckii NCIMB 8052, we sought to downregulate catabolite control protein A (CcpA) using the M1GS ribozyme technology. A
Victor Chinomso Ujor   +4 more
doaj   +1 more source

Carbon Catabolite Repression and the Related Genes of ccpA, ptsH and hprK in Thermoanaerobacterium aotearoense. [PDF]

open access: yesPLoS ONE, 2015
The strictly anaerobic, Gram-positive bacterium, Thermoanaerobacterium aotearoense SCUT27, is capable of producing ethanol, hydrogen and lactic acid by directly fermenting glucan, xylan and various lignocellulosically derived sugars.
Muzi Zhu   +4 more
doaj   +1 more source

A New Mechanism of Carbon Metabolism and Acetic Acid Balance Regulated by CcpA

open access: yesMicroorganisms, 2023
Catabolite control protein A (CcpA) is a critical regulator in Gram-positive bacteria that orchestrates carbon metabolism by coordinating the utilization of different carbon sources.
Yupeng Zhang   +5 more
doaj   +1 more source

CcpA-Dependent Carbon Catabolite Repression Regulates Fructooligosaccharides Metabolism in Lactobacillus plantarum

open access: yesFrontiers in Microbiology, 2018
Fructooligosaccharides (FOSs) metabolism in Lactobacillus plantarum is controlled by two gene clusters, and the global regulator catabolite control protein A (CcpA) may be involved in the regulation. To understand the mechanism, this study focused on the
Chen Chen   +4 more
doaj   +1 more source

CcpA Affects Infectivity of Staphylococcus aureus in a Hyperglycemic Environment

open access: yesFrontiers in Cellular and Infection Microbiology, 2017
Many bacteria regulate the expression of virulence factors via carbon catabolite responsive elements. In Gram-positive bacteria, the predominant mediator of carbon catabolite repression is the catabolite control protein A (CcpA).
Markus Bischoff   +14 more
doaj   +1 more source

HP0197 contributes to CPS synthesis and the virulence of Streptococcus suis via CcpA. [PDF]

open access: yesPLoS ONE, 2012
Streptococcus suis serotype 2 (SS2), a major swine pathogen and an emerging zoonotic agent, has greatly challenged global public health. The encoding proteins with unknown functions the bacterium encodes are an obstruction to studies of the pathogenesis.
Anding Zhang   +7 more
doaj   +1 more source

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