Results 101 to 110 of about 392,034 (291)

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Supplementation of Calcium Through Seed Enrichment Technique Enhances Germinability and Early Growth of Timothy (Phleum pratense L.) Under Salinity Conditions

Agronomy
Calcium ameliorates salt-related growth defects in plants. The objective of this study was to determine whether supplying calcium through a seed enrichment technique enhances the germinability and early growth of timothy (Phleum pratense L.) under saline
Masahiro Akimoto, Li Ma
doaj   +1 more source

Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death. [PDF]

, 2012
The altered metabolism of cancer can render cells dependent on the availability of metabolic substrates for viability. Investigating the signaling mechanisms underlying cell death in cells dependent upon glucose for survival, we demonstrate that glucose ...
Graeber, Thomas G, Graham, Nicholas A, Kohli, Bitika, Komisopoulou, Evangelia, Lo, Roger S, Mellinghoff, Ingo K, Mischel, Paul S, Ribas, Antoni, Tahmasian, Martik, Teitell, Michael A, Vivanco, Igor, Wu, Hong, Zhu, Maggie   +12 more
core  

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

Salen Mn Complexes Mitigate Radiation Injury in Normal Tissues [PDF]

, 2011
Salen Mn complexes, including EUK-134, EUK-189 and a newer cyclized analog EUK-207, are synthetic SOD/catalase mimetics that have beneficial effects in many models of oxidative stress.
Doctrow, Susan R., Fish, Brian, Hill, Richard P., Huffman, Karl D., Lazarova, Zelmira, Mahmood, Javed, Medhora, Meetha, Molthen, Robert C., Moulder, John E., Rosenthal, Rosalind A., Sonis, Stephen T., Tofilon, Philip J.   +11 more
core   +2 more sources

Catalytic fuel cell used as an analytical tool for methanol and ethanol determination. Application to ethanol determination in alcoholic beverages [PDF]

, 2016
A small direct catalytic methanol 'fuel cell' was used for analytical purposes. Three different formats were investigated for methanol and ethanol determination: two different Open Circuit Voltage (OCV) formats and a potentiostatic (i.e.
Giovanni Merola, Luigi Campanella, Mauro Castrucci, Mauro Tomassetti, Riccardo Angeloni   +4 more
core   +1 more source

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

ФЕРМЕНТАТИВНАЯ АКТИВНОСТЬ ПЕЧЕНИ КРУПНОГО РОГАТОГО СКОТА ПРИ ФАСЦИОЛЕЗЕ

Ветеринарная патология, 2012
The aim of the research was to study the activity of the enzyme system processes transamination, urea formation, antioxidant protection in cattle liver with fascioliasis to determine the host-parasite relationships and conduct pathogenic therapy.

doaj  

Effects of single mutations on the stability of horseradish peroxidase to hydrogen peroxide [PDF]

, 2007
Horseradish peroxidase (HRP) is a commonly used enzyme in many biotechnological fields. Improvement of HRP stability would further increase its potential application range.
Arnold, Barry J. Ryan, Bateman, Borole, Ciarán Ó'Fágáin, Hernández-Ruiz, Hiner, Hiner, Hiner, Lehmann, Lei, Maniatis, Miyazaki, O'Brien, Ryan, Schmidt, Valderrama, Wang, Wanger   +18 more
core   +2 more sources

Biomimetic Ru‐Mn Nanozyme with Cascade Catalytic Activity Attenuates Secondary Brain Injury in Intracerebral Hemorrhage

Advanced Science, EarlyView.
Ru–Mn composite nanozymes are engineered to mimic dual‐enzyme cascade catalysis, enabling efficient ROS clearance and neuroinflammation suppression. In collagenase‐ and autologous blood‐induced ICH mouse models, intranasal and intravenous administration reduced hematoma volume, preserved BBB integrity, and improved neurological recovery.
Zhongxin Duan, Peng Li, Yue Wang, Xin Qi, Wanyu Wang, Yongzhong Cheng, Huabin Zhang, Xin Hu, Xiang Gao   +8 more
wiley   +1 more source