Results 101 to 110 of about 4,561,775 (254)
BMC Genomics, 2005 Background Small G proteins, which are essential regulators of multiple cellular functions, are activated by guanine nucleotide exchange factors (GEFs) that stimulate the exchange of the tightly bound GDP nucleotide by GTP.
Geldner Niko +8 more
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The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability [PDF]
, 2016 USP21 is a centrosome-associated deubiquitylase (DUB) that has been implicated in the formation of primary cilia - crucial organelles for the regulation of the Hedgehog (Hh) signaling pathway in vertebrates. Here, we identify KCTD6 - a cullin-3 E3-ligase
Bertsoulaki, Erithelgi +6 more
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Activities and properties of calcineurin catalytic domain
Chinese Science Bulletin, 2000 Calcineurin (CN) is the only protein phosphatase known to be under the control of calcium (Ca2+) and calmodulin (CaM). The enzyme consists of two subunits, the catalytic A subunit of 61 ku (CNA) and a regulatory B subunit of 19 ku (CNB). In this study, we used PCR amplication to construct a truncation consisting of only the CNA catalytic domain.
Shujie Yang, Li Zhang, Qun Wei
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BiomoleculesThe Src homology 2 domain-containing inositol 5-phosphatase 1 (SHIP1) is a multidomain protein consisting of two protein–protein interaction domains, the Src homology 2 (SH2) domain, and the proline-rich region (PRR), as well as three phosphoinositide ...
Spike Murphy Müller +2 more
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Evidence for disulfide bonds in SR Protein Kinase 1 (SRPK1) that are required for activity and nuclear localization. [PDF]
PLoS ONE, 2017 Serine/arginine protein kinases (SRPKs) phosphorylate Arg/Ser dipeptide-containing proteins that play crucial roles in a broad spectrum of basic cellular processes.
Maria Koutroumani +4 more
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A new subfamily of fungal subtilases: structural and functional analysis of a Pleurotus ostreatus member [PDF]
, 2005 Pleurotus ostreatus produces several extracellular proteases which are believed to be involved in the regulation of the ligninolytic activities of this fungus. Recently, purification and characterization of the most abundant P.
FARACO, VINCENZA +5 more
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Catalytic domains in porous catalysts
, 2018 Understanding of the catalytic domains within porous catalysts is essential for control of these systems in order to obtain desired reaction yields and selectivities. This body of work consists of studies on two types of porous catalysts, mesoporous silica and zeolites, that can have interesting cooperative catalytic interactions between the inorganic ...
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1.92 Angstrom Zinc-Free APOBEC3F Catalytic Domain Crystal Structure [PDF]
Journal of Molecular Biology, 2016 The APOBEC3 family of DNA cytosine deaminases is capable of restricting the replication of HIV-1 and other pathogens. Here, we report a 1.92 Å resolution crystal structure of the Vif-binding and catalytic domain of APOBEC3F (A3F). This structure is distinct from the previously published APOBEC and phylogenetically related deaminase structures, as it is
Shaban, Nadine M. +4 more
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Mutational analysis of two residues in the DYRK homology box of the protein kinase DYRK1A
BMC Research Notes, 2018 Objective Dual specificity tyrosine phosphorylation-regulated kinases (DYRK) contain a characteristic sequence motif (DYRK homology box, DH box) that is located N-terminal of the catalytic domain and supports the autophosphorylation of a conserved ...
Esti Wahyu Widowati +2 more
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The enzymatic processing of α-dystroglycan by MMP-2 is controlled by two anchoring sites distinct from the active site. [PDF]
PLoS ONE, 2018 Dystroglycan (DG) is a membrane receptor, belonging to the dystrophin-glycoprotein complex (DGC) and formed by two subunits, α-dystroglycan (α-DG) and β-dystroglycan (β -DG).
Magda Gioia +12 more
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