Results 141 to 150 of about 4,561,775 (254)

Pmt4 recognizes two separate acceptor sites to O-mannosylate in the S/T-rich regions of substrate proteins

Nature Communications
Protein O-mannosyltransferases (PMTs) add mannose to serine/threonine (S/T)-rich proteins in the endoplasmic reticulum, facilitating proper folding and trafficking through the secretory pathway.
Minge Du, Zuanning Yuan, Amanda Kovach, Meinan Lyu, Huilin Li   +4 more
doaj   +1 more source

Novel Anti-Mesothelin Nanobodies and Recombinant Immunotoxins with Pseudomonas Exotoxin Catalytic Domain for Cancer Therapeutics. [PDF]

Mol Cells, 2023
Nguyen MQ, Kim DH, Shim HJ, Ta HKK, Vu TL, Nguyen TKO, Lim JC, Choe H.   +7 more
europepmc   +1 more source

Fyn-Mediated Regulation of Protein Kinase A [PDF]

, 2017
Protein kinases are enzymes important for signal transduction in the regulation of cellular processes. The cAMP-dependent protein kinase A (PKA) has been previously reported to regulate the activity of the Src family kinase Fyn, an event important for ...
Barritt, Sam
core   +1 more source

Bacterial chemoreceptor signaling complexes control kinase activity by stabilizing the catalytic domain of CheA. [PDF]

Proc Natl Acad Sci U S A, 2023
Tran T, Karunanayake Mudiyanselage APKK, Eyles SJ, Thompson LK.   +3 more
europepmc   +1 more source

Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85β/AP2-mediated endocytosis

Nature Communications
Class IA phosphoinositide 3-kinase (PI3K) galvanizes fundamental cellular processes such as migration, proliferation, and differentiation. To enable these multifaceted roles, the catalytic subunit p110 utilizes the multi-domain, regulatory subunit p85 ...
Hideaki T. Matsubayashi, Jack Mountain, Nozomi Takahashi, Abhijit Deb Roy, Tony Yao, Amy F. Peterson, Cristian Saez Gonzalez, Ibuki Kawamata, Takanari Inoue   +8 more
doaj   +1 more source

The Structure and Nucleotide-Binding Characteristics of Regulated Cystathionine β-Synthase Domain-Containing Pyrophosphatase without One Catalytic Domain. [PDF]

Int J Mol Sci, 2023
Zamakhov IM, Anashkin VA, Moiseenko AV, Orlov VN, Vorobyeva NN, Sokolova OS, Baykov AA.   +6 more
europepmc   +1 more source

Point mutations in the catalytic domain disrupt cellulose synthase (CESA6) vesicle trafficking and protein dynamics. [PDF]

Plant Cell, 2023
Huang L, Zhang W, Li X, Staiger CJ, Zhang C.   +4 more
europepmc   +1 more source

Structure, function and inhibition of poly(ADP-ribose)polymerase, member 14 (PARP14) [PDF]

, 2018
Levonis, Stephan M, Schweiker, Stephanie S, Sherry, Madeleine, Tauber, Amanda   +3 more
core   +1 more source

Catalytic domain-dependent and -independent transcriptional activities of the tumour suppressor histone H3K27 demethylase UTX/KDM6A in specific cancer types. [PDF]

Epigenetics, 2023
Sun W, Lee KL, Poellinger L, Masai H, Kato H.   +4 more
europepmc   +1 more source

Crystal Structure of the Catalytic Domain of a Botulinum Neurotoxin Homologue from Enterococcus faecium: Potential Insights into Substrate Recognition. [PDF]

Int J Mol Sci, 2023
Gregory KS, Hall PR, Onuh JP, Mojanaga OO, Liu SM, Acharya KR.   +5 more
europepmc   +1 more source