Results 11 to 20 of about 4,561,775 (254)
The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain. [PDF]
eLife, 2016 GPIHBP1 is a glycolipid-anchored membrane protein of capillary endothelial cells that binds lipoprotein lipase (LPL) within the interstitial space and shuttles it to the capillary lumen.
Beigneux, Anne P +9 more
core +5 more sources
Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain [PDF]
Journal of Biological Chemistry, 2015 Functional and deep sequencing studies have combined to demonstrate the involvement of APOBEC3B in cancer mutagenesis. APOBEC3B is a single-stranded DNA cytosine deaminase that functions normally as a nuclear-localized restriction factor of DNA-based pathogens.
Ke, Shi +4 more
openaire +3 more sources
Complete Determination of the Pin1 Catalytic Domain Thermodynamic Cycle by NMR Lineshape Analysis [PDF]
Journal of Biomolecular NMR, 2011 The phosphorylation-specific peptidyl-prolyl isomerase Pin1 catalyzes the isomerization of the peptide bond preceding a proline residue between cis and trans isomers.
De, Soumya +5 more
core +3 more sources
Structure/function of the soluble guanylyl cyclase catalytic domain
Nitric Oxide, 2018 Soluble guanylyl cyclase (GC-1) is the primary receptor of nitric oxide (NO) in smooth muscle cells and maintains vascular function by inducing vasorelaxation in nearby blood vessels. GC-1 converts guanosine 5'-triphosphate (GTP) into cyclic guanosine 3',5'-monophosphate (cGMP), which acts as a second messenger to improve blood flow.
Childers, Kenneth C., Garcin, Elsa D.
openaire +3 more sources
Selective targeting of TET catalytic domain promotes somatic cell reprogramming
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Ten-eleven translocation (TET) proteins mainly express during embryonic development and regulate tissue-specific differentiation. However, their specific role in somatic cell reprogramming is elusive.
Anup K Singh +9 more
semanticscholar +1 more source
Crystal Structures Reveal Hidden Domain Mechanics in Protein Kinase A (PKA)
Biology, 2023 Cyclic-AMP-dependent protein kinase A (PKA) is a critical enzyme involved in various signaling pathways that plays a crucial role in regulating cellular processes including metabolism, gene transcription, cell proliferation, and differentiation.
Colin L. Welsh +2 more
doaj +1 more source
Applied Sciences, 2020 β-mannanase is one of the key enzymes to hydrolyze hemicellulose. At present, most β-mannanases are not widely applied because of their low enzyme activity and unsuitable enzymatic properties.
Huijing Liu, Jie Liu, Tangbing Cui
doaj +1 more source
SCOPEC: a database of protein catalytic domains [PDF]
Bioinformatics, 2004 Abstract Motivation: Domains are the units of protein structure, function and evolution. It is therefore essential to utilize knowledge of domains when studying the evolution of function, or when assigning function to genome sequence data.
Richard A, George +4 more
openaire +2 more sources
Architecture and function of metallopeptidase catalytic domains [PDF]
Protein Science, 2013 AbstractThe cleavage of peptide bonds by metallopeptidases (MPs) is essential for life. These ubiquitous enzymes participate in all major physiological processes, and so their deregulation leads to diseases ranging from cancer and metastasis, inflammation, and microbial infection to neurological insults and cardiovascular disorders.
Nýria Cerdý-Costa +1 more
openaire +3 more sources
Crystal Structure of Human Nocturnin Catalytic Domain [PDF]
Scientific Reports, 2018 Abstract Nocturnin (NOCT) helps the circadian clock to adjust metabolism according to day and night activity. NOCT is upregulated in early evening and it has been proposed that NOCT serves as a deadenylase for metabolic enzyme mRNAs. We present a 2.7-Å crystal structure of the catalytic domain of human NOCT.
Michael A. Estrella +2 more
openaire +2 more sources