Results 21 to 30 of about 349,791 (266)
Tetrameric Structure of a Serine Integrase Catalytic Domain [PDF]
Structure, 2008 The serine integrases have recently emerged as powerful new chromosome engineering tools in various organisms and show promise for therapeutic use in human cells. The serine integrases are structurally and mechanistically unrelated to the bacteriophage lambda integrase but share a similar catalytic domain with the resolvase/invertase enzymes typified ...
Yuan, Peng +2 more
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Hybrid and rogue kinases encoded in the genomes of model eukaryotes. [PDF]
PLoS ONE, 2014 The highly modular nature of protein kinases generates diverse functional roles mediated by evolutionary events such as domain recombination, insertion and deletion of domains.
Ramaswamy Rakshambikai +2 more
doaj +1 more source
A Monoclonal Antibody Against the Catalytic Domain of PTP1B [PDF]
Hybridoma, 2012 Protein tyrosine phosphatase 1B (PTP1B), a member of the protein tyrosine phosphatase (PTP) family, plays a crucial role in metabolic signaling, with insulin and leptin signaling being well studied. New evidence indicates that PTP1B is also involved in cancer.
Zeng, Fanwei +9 more
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Essential role of the C-terminal helical domain in active site formation of selenoprotein MsrA from Clostridium oremlandii. [PDF]
PLoS ONE, 2015 We previously determined the crystal structures of 1-Cys type selenoprotein MsrA from Clostridium oremlandii (CoMsrA). The overall structure of CoMsrA is unusual, consisting of two domains, the N-terminal catalytic domain and the C-terminal distinct ...
Eun Hye Lee +3 more
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Catalytic Domain Architecture of Metzincin Metalloproteases [PDF]
Journal of Biological Chemistry, 2009 Metalloproteases cleave proteins and peptides, and deregulation of their function leads to pathology. An understanding of their structure and mechanisms of action is necessary to the development of strategies for their regulation. Among metallopeptidases are the metzincins, which are mostly multidomain proteins with approximately 130-260-residue ...
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The chitinase C gene PsChiC from Pseudomonas sp. and its synergistic effects on larvicidal activity
Genetics and Molecular Biology, 2015 Pseudomonas sp. strain TXG6-1, a chitinolytic gram-negative bacterium, was isolated from a vegetable field in Taixing city, Jiangsu Province, China. In this study, a Pseudomonas chitinase C gene (PsChiC) was isolated from the chromosomal DNA of this ...
Wanfang Zhong, Shaojun Ding, Huifang Guo
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eLife, 2022 Mycobacterium tuberculosis adenylyl cyclase (AC) Rv1625c/Cya is an evolutionary ancestor of the mammalian membrane ACs and a model system for studies of their structure and function.
Ved Mehta +9 more
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Phospholipid binding to the FAK catalytic domain impacts function. [PDF]
PLoS ONE, 2017 Focal adhesion kinase is an essential nonreceptor tyrosine kinase that plays an important role in development, in homeostasis and in the progression of human disease.
Jessica E Hall, Michael D Schaller
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Crystal Structure of Human Nocturnin Catalytic Domain [PDF]
Scientific Reports, 2018 Abstract Nocturnin (NOCT) helps the circadian clock to adjust metabolism according to day and night activity. NOCT is upregulated in early evening and it has been proposed that NOCT serves as a deadenylase for metabolic enzyme mRNAs. We present a 2.7-Å crystal structure of the catalytic domain of human NOCT.
Michael A. Estrella +2 more
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Molecules, 2021 Commensal bacterium Clostridium paraputrificum J4 produces several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N′-diacetyl-β-d-chitobioside (pNGG).
Jan Dohnálek +7 more
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