SCOPEC: a database of protein catalytic domains [PDF]
Bioinformatics, 2004 Abstract Motivation: Domains are the units of protein structure, function and evolution. It is therefore essential to utilize knowledge of domains when studying the evolution of function, or when assigning function to genome sequence data.
Richard A. George +4 more
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Architecture and function of metallopeptidase catalytic domains [PDF]
Protein Science, 2013 AbstractThe cleavage of peptide bonds by metallopeptidases (MPs) is essential for life. These ubiquitous enzymes participate in all major physiological processes, and so their deregulation leads to diseases ranging from cancer and metastasis, inflammation, and microbial infection to neurological insults and cardiovascular disorders.
Nýria Cerdý-Costa +1 more
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Minimal catalytic domain of N-acetylglucosaminyltransferase V [PDF]
Glycobiology, 2000 UDP-GlcNAc: Manalpha1-6Manbeta-R beta1-6 N-acetylglucosaminyltransferase V (EC 2.4.1.155, GlcNAc-TV) is a Golgi enzyme that substitutes the trimannosyl core in the biosynthetic pathway for complex-type N-linked glycans. GlcNAc-TV activity is regulated by oncogenes frequently activated in cancer cells ( ras, src, and her2/neu ) and by activators of T ...
Korczak B. +4 more
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Expression, Purification and evaluation of the Immunogenicity of RecombinantC-terminus of the Receptor-Binding Domain of Neurotoxin Botulinum Protein Type B (BoNT/B-HcC) [PDF]
مجله علمی دانشگاه علوم پزشکی کردستان, 2023 Background and Aim: Botulism, a syndrome caused by food poisoning, results from use of food contaminated with the botulinum toxin, which is very dangerous and deadly.
Hossein Samiei Abianeh +5 more
doaj
The TriTryp Phosphatome: analysis of the protein phosphatase catalytic domains [PDF]
BMC Genomics, 2007 AbstractBackgroundThe genomes of the three parasitic protozoaTrypanosoma cruzi,Trypanosoma bruceiandLeishmania majorare the main subject of this study. These parasites are responsible for devastating human diseases known as Chagas disease, African sleeping sickness and cutaneous Leishmaniasis, respectively, that affect millions of people in the ...
Brenchley, Rachel +7 more
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Structural-Functional Analysis Reveals a Specific Domain Organization in Family GH20 Hexosaminidases. [PDF]
PLoS ONE, 2015 Hexosaminidases are involved in important biological processes catalyzing the hydrolysis of N-acetyl-hexosaminyl residues in glycosaminoglycans and glycoconjugates.
Cristina Val-Cid +3 more
doaj +1 more source
Structural Insight of a Trimodular Halophilic Cellulase with a Family 46 Carbohydrate-Binding Module. [PDF]
PLoS ONE, 2015 Cellulases are the key enzymes used in the biofuel industry. A typical cellulase contains a catalytic domain connected to a carbohydrate-binding module (CBM) through a flexible linker.
Huaidong Zhang +6 more
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Kinetic Analysis of the Catalytic Domain of Human Cdc25B [PDF]
Journal of Biological Chemistry, 1996 The Cdc25 cell cycle regulator is a member of the dual-specificity class of protein-tyrosine phosphatases that hydrolyze phosphotyrosine- and phosphothreonine-containing substrates. To study the mechanism of Cdc25B, we have overexpressed and purified the catalytic domain of human Cdc25B (Xu, X., and Burke, S. P. (1996) J. Biol. Chem.
E B, Gottlin +6 more
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Structural and functional characterization of mature forms of metalloprotease E495 from Arctic sea-ice bacterium Pseudoalteromonas sp. SM495. [PDF]
PLoS ONE, 2012 E495 is the most abundant protease secreted by the Arctic sea-ice bacterium Pseudoalteromonas sp. SM495. As a thermolysin family metalloprotease, E495 was found to have multiple active forms in the culture of strain SM495.
Hai-Lun He +8 more
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Modulation of catalytic activity in multi-domain protein tyrosine phosphatases. [PDF]
PLoS ONE, 2011 Signaling mechanisms involving protein tyrosine phosphatases govern several cellular and developmental processes. These enzymes are regulated by several mechanisms which include variation in the catalytic turnover rate based on redox stimuli, subcellular
Lalima L Madan +5 more
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