Autoantibodies against the catalytic domain of BRAF are not specific serum markers for rheumatoid arthritis. [PDF]
PLoS ONE, 2011 BACKGROUND: Autoantibodies to the catalytic domain of v-raf murine sarcoma viral oncogene homologue B1 (BRAF) have been recently identified as a new family of autoantibodies involved in rheumatoid arthritis (RA).
Wenli Li +8 more
doaj +1 more source
Polyhydroxyalkanoate synthase (PhaC): The key enzyme for biopolyester synthesis
Current Research in Biotechnology, 2022 Polyhydroxyalkanoates (PHAs) are considered good candidates in replacing commercial petrochemical plastics in certain applications like single-use packaging since they are biodegradable, biocompatible and share similar properties with conventional ...
Soon Zher Neoh +6 more
doaj +1 more source
Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation [PDF]
Nucleic Acids Research, 2017 The catalytic activity of human cytidine deaminase APOBEC3B (A3B) has been correlated with kataegic mutational patterns within multiple cancer types. The molecular basis of how the N-terminal non-catalytic CD1 regulates the catalytic activity and consequently, biological function of A3B remains relatively unknown.
Xiao, Xiao +7 more
openaire +4 more sources
Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation [PDF]
, 2018 The E3 ligase parkin ubiquitinates outer mitochondrial membrane proteins during oxidative stress and is linked to early-onset Parkinson’s disease. Parkin is autoinhibited but is activated by the kinase PINK1 that phosphorylates ubiquitin leading to ...
Aguirre, Jacob D. +9 more
core +1 more source
The many-faced KSR1: a tumor suppressor in breast cancer [PDF]
, 2015 Emerging evidence supports the dual function of kinase suppressor of Ras 1 (KSR1) as an active kinase and a scaffold, although it has been extensively referred as a pseudokinase, due to the absence of key residues in its catalytic domain [1, 2].
Giamas, Georgios +2 more
core +2 more sources
Template-Directed Self-Assembly Enhances RTK Catalytic Domain Function [PDF]
SLAS Discovery, 2008 Receptor tyrosine kinases have become important therapeutic targets because of their involvement in diseases, including cancer. Kinase domains, which are soluble and easily purified, have found widespread use in enzyme inhibitor assays, but these domains do not exhibit full function because they are isolated from the membrane.
Esposito, EA, Shrout, AL, Weis, RM
openaire +2 more sources
Structure of the catalytic domain of the colistin resistance enzyme MCR-1
BMC Biology, 2016 Due to the paucity of novel antibiotics, colistin has become a last resort antibiotic for treating multidrug resistant bacteria. Colistin acts by binding the lipid A component of lipopolysaccharides and subsequently disrupting the bacterial membrane. The
V. Stojanoski +5 more
semanticscholar +1 more source
Genetic evidence for Pak1 autoinhibition and its release by Cdc42 [PDF]
, 1999 Pak1 protein kinase of Schizosaccharomyces pombe, a member of the p21-GTPase-activated protein kinase (PAK) family, participates in signaling pathways including sexual differentiation and morphogenesis. The regulatory domain of PAK proteins is thought to
Tu, H., Wigler, M. H.
core +1 more source
β‐Helical catalytic domains in glycoside hydrolase families 49, 55 and 87: domain architecture, modelling and assignment of catalytic residues [PDF]
FEBS Letters, 2002 X‐ray crystallography and bioinformatics studies reveal a tendency for the right‐handed β‐helix domain architecture to be associated with carbohydrate binding proteins. Here we demonstrate the presence of catalytic β‐helix domains in glycoside hydrolase (GH) families 49, 55 and 87 and provide evidence for their sharing a common evolutionary ancestor ...
Rigden, Daniel J, Franco, Octávio L
openaire +2 more sources
High resolution crystal structure of the catalytic domain of MCR-1
Scientific Reports, 2016 The newly identified mobile colistin resistant gene (mcr-1) rapidly spread among different bacterial strains and confers colistin resistance to its host, which has become a global concern.
Guixing Ma +4 more
semanticscholar +1 more source