Results 61 to 70 of about 365,538 (313)

MACiE: a database of enzyme reaction mechanisms.

, 2005
SUMMARY: MACiE (mechanism, annotation and classification in enzymes) is a publicly available web-based database, held in CMLReact (an XML application), that aims to help our understanding of the evolution of enzyme catalytic mechanisms and also to create
Gemma L. Holliday, Bartlett, G J, Noel M. O'Boyle, Janet M. Thornton, O'Boyle, N M, Peter Murray-Rust, John B. O. Mitchell, Holliday, G L, Almonacid, D E, Murray-Rust, P, Daniel E. Almonacid, Thornton, J M, Mitchell, John Blayney Owen, Gail J. Bartlett   +13 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A bifunctional endolytic alginate lyase with two different lyase catalytic domains from Vibrio sp. H204

Frontiers in Microbiology
Alginate lyases can fully degrade alginate into various size-defined unsaturated oligosaccharide products by β-elimination. Here, we identified the bifunctional endolytic alginate lyase Aly35 from the marine bacterium Vibrio sp. Strain H204.
Chune Peng, Qingbin Wang, Qingbin Wang, Wei Xu, Xinkun Wang, Qianqian Zheng, Xiaohui Liang, Xiaodan Dong, Fuchuan Li, Lizeng Peng   +9 more
doaj   +1 more source

Functional characterization of DYRK1A missense variants associated with a syndromic form of intellectual deficiency and autism

Biology Open, 2018
Haploinsufficiency of DYRK1A is a cause of a neurodevelopmental syndrome termed mental retardation autosomal dominant 7 (MRD7). Several truncation mutations, microdeletions and missense variants have been identified and result in a recognizable ...
Esti Wahyu Widowati, Sabrina Ernst, Ralf Hausmann, Gerhard Müller-Newen, Walter Becker   +4 more
doaj   +1 more source

Unconventional structure and mechanisms for membrane interaction and translocation of the NF-κB-targeting toxin AIP56

Nature Communications, 2023
Bacterial AB toxins are secreted key virulence factors that are internalized by target cells through receptor-mediated endocytosis, translocating their enzymatic domain to the cytosol from endosomes (short-trip) or the endoplasmic reticulum (long-trip ...
Johnny Lisboa, Cassilda Pereira, Rute D. Pinto, Inês S. Rodrigues, Liliana M. G. Pereira, Bruno Pinheiro, Pedro Oliveira, Pedro José Barbosa Pereira, Jorge E. Azevedo, Dominique Durand, Roland Benz, Ana do Vale, Nuno M. S. dos Santos   +12 more
doaj   +1 more source

Complementary function of the two catalytic domains of APOBEC3G

Virology, 2005
The HIV-1 viral accessory protein Vif prevents the encapsidation of the antiviral cellular cytidine deaminases APOBEC3F and APOBEC3G by inducing their proteasomal degradation. In the absence of Vif, APOBEC3G is encapsidated and blocks virus replication by deaminating cytosines of the viral cDNA.
Navarro, Francisco, Bollman, Brooke, Chen, Hui, König, Renate, Yu, Qin, Chiles, Kristopher, Landau, Nathaniel R.   +6 more
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The inherent flexibility of type I non-ribosomal peptide synthetase multienzymes drives their catalytic activities

Open Biology, 2021
Non-ribosomal peptide synthetases (NRPSs) are multienzymes that produce complex natural metabolites with many applications in medicine and agriculture.
Sarah Bonhomme, Andréa Dessen, Pauline Macheboeuf   +2 more
doaj   +1 more source

Ferredoxin containing bacteriocins suggest a novel mechanism of iron uptake in Pectobacterium spp [PDF]

, 2012
In order to kill competing strains of the same or closely related bacterial species, many bacteria produce potent narrow-spectrum protein antibiotics known as bacteriocins.
Joel Milner (178619), Walker, D., Rhys Grinter, Joel Milner, Daniel Walker (178621), Walker, Daniel, Milner, J., Rhys Grinter (178616), Grinter Rhys, Milner Joel, Walker Daniel, Daniel Walker, Milner, Joel, Grinter, Rhys, Grinter, R.   +14 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source