Phototriggering Nitric Oxide Synthase from Geobacillus stearothermophilus [PDF]
, 2012 Nitric oxide synthases (NOS) produce L-citrulline and nitric oxide (NO) in two turnovers from L-arginine via the bound intermediate, N-hydroxy-L-arginine.
Keller, Gretchen Eva +1 more
core +1 more source
Matrix metalloproteinases: Fold and function of their catalytic domains
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2010 Matrix metalloproteinases (MMPs) are zinc-dependent protein and peptide hydrolases. They have been almost exclusively studied in vertebrates and 23 paralogs are present in humans. They are widely involved in metabolism regulation through both extensive protein degradation and selective peptide-bond hydrolysis.
Tallant, Cynthia +2 more
openaire +3 more sources
Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation [PDF]
Nucleic Acids Research, 2017 The catalytic activity of human cytidine deaminase APOBEC3B (A3B) has been correlated with kataegic mutational patterns within multiple cancer types. The molecular basis of how the N-terminal non-catalytic CD1 regulates the catalytic activity and consequently, biological function of A3B remains relatively unknown.
Xiao, Xiao +7 more
openaire +4 more sources
The impact of the human DNA topoisomerase II C-terminal domain on activity [PDF]
, 2008 Background Type II DNA topoisomerases (topos) are essential enzymes needed for the resolution of topological problems that occur during DNA metabolic processes.
West, K.L. +11 more
core +1 more source
A small molecule inhibitor of leucine carboxyl methyltransferase-1 inhibits cancer cell survival
Frontiers in Drug DiscoveryReversible phosphorylation is the basis for signal transduction in eukaryotic cells, and this is tightly controlled by the complex interplay of kinases and phosphatases.
O. A. Arosarena +4 more
doaj +1 more source
Resuscitation-promoting factors possess a lysozyme-like domain [PDF]
, 2004 The novel bacterial cytokine family – resuscitation-promoting factors (Rpfs) – share a conserved domain of uncharacterized function. Predicting the structure of this domain suggests that Rpfs possess a lysozyme-like domain.
Davies, A.P. +6 more
core +1 more source
Integral Characteristic of Complex Catalytic Reaction Accompanied by Deactivation
, 2022 New theoretical relationships for a complex catalytic reaction accompanied by deactivation are obtained, using as an example the two-step catalytic mechanism (Temkin–Boudart mechanism) with irreversible reactions and irreversible deactivation.
Zoë Gromotka +3 more
core +1 more source
Identification of residues in the heme domain of soluble guanylyl cyclase that are important for basal and stimulated catalytic activity. [PDF]
PLoS ONE, 2011 Nitric oxide signals through activation of soluble guanylyl cyclase (sGC), a heme-containing heterodimer. NO binds to the heme domain located in the N-terminal part of the β subunit of sGC resulting in increased production of cGMP in the catalytic domain
Padmamalini Baskaran +3 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
FEBS Open Bio, 2022 Acetylxylan esterase from Caldanaerobacter subterraneus subsp. tengcongensis (TTE0866) has an N‐terminal region (NTR; residues 23–135) between the signal sequence (residues 1–22) and the catalytic domain (residues 136–324), which is of unknown function ...
Kohei Sasamoto +6 more
doaj +1 more source