Results 51 to 60 of about 574,974 (306)

Molecular dissection of the domain architecture and catalytic activities of human PrimPol [PDF]

, 2014
PrimPol is a primase–polymerase involved in nuclear and mitochondrial DNA replication in eukaryotic cells. Although PrimPol is predicted to possess an archaeo-eukaryotic primase and a UL52-like zinc finger domain, the role of these domains has not been ...
Aidan J. Doherty, Aravind, Benjamin A. Keen, Bianchi, Biertümpfel, Biswas, Bocquier, Boudsocq, Brautigam, Chen, Chen, Connolly, Corn, Della, Duncan, Engelke, Fogg, Frick, Garcia-Gomez, Graziewicz, Griep, Hays, Iyer, Johnson, Julie Bianchi, Kim, Lao-Sirieix, Lao-Sirieix, Laura J. Bailey, Lehmann, Lipps, Liu, Maga, Masutani, Mendelman, Ohashi, Pelletier, Pinz, Pitcher, Rudd, Shannon, Stanislaw K. Jozwiakowski, Tabor, van Loon, Wan, Washington   +45 more
core   +2 more sources

β‐Helical catalytic domains in glycoside hydrolase families 49, 55 and 87: domain architecture, modelling and assignment of catalytic residues [PDF]

FEBS Letters, 2002
X‐ray crystallography and bioinformatics studies reveal a tendency for the right‐handed β‐helix domain architecture to be associated with carbohydrate binding proteins. Here we demonstrate the presence of catalytic β‐helix domains in glycoside hydrolase (GH) families 49, 55 and 87 and provide evidence for their sharing a common evolutionary ancestor ...
Rigden, Daniel J, Franco, Octávio L
openaire   +2 more sources

The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family [PDF]

, 2015
The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that have diverse roles in tissue morphogenesis and patho-physiological remodeling, in ...
A Colige, A Didangelos, A Luque, A Moncada-Pazos, A Noel, A Tan Ide, AC Jonsson-Rylander, AC Nicholson, AJ Fosang, B Joe, BH Koo, BH Koo, BV Nusgens, C Casal, C Esselens, C Gendron, C Kintakas, C Lopez-Otin, C Ricciardelli, CB Kern, CG Viloria, CH Mjaatvedt, CJ Liu, CJ Liu, CL Jacobi, CM Dancevic, CN Brocker, CR Flannery, D Wagsater, DL Russell, DL Silver, DR Edwards, DR McCulloch, DT Jones, Dylan R Edwards, EA Lin, EC Arner, ED Karagiannis, EM Majerus, F Guo, F Vazquez, FG Brunet, FX Gomis-Ruth, FX Gomis-Ruth, G Gao, G Gao, G Hashimoto, G Murphy, GC Choi, GE Lind, GG Levy, GJ Wayne, Grant N Wheeler, H Enomoto, H Jin, H Stanton, H Stanton, HL Lung, HM Brown, I Abbaszade, I Peluso, Ines Desanlis, J Dubail, J Dubail, J Felsenstein, J Hofsteenge, J Huxley-Jones, J Huxley-Jones, J Morales, JA Pyun, JC Adams, JC Rodriguez-Manzaneque, JC Rodriguez-Manzaneque, JC Rodriguez-Manzaneque, JD Sandy, JM Longpre, K Demircan, K Fujikawa, K Gopalakrishnan, K Kuno, K Kuno, K Stankunas, K Tamura, K Yamamoto, K Yamamoto, L Angerer, L Faivre, L Mittaz, L Mosyak, L Troeberg, L Troeberg, L Troeberg, L Wagstaff, LA Collins-Racie, LE Dupuis, LM Ricketts, M Cudic, M Hour El, M Kashiwagi, M Krampert, M Llamazares, MA Aldahmesh, MD Tortorella, MN Vankemmelbeke, N Dagoneau, N Hattori, N Rocks, N Rocks, N Stupka, NH Lim, NV Lee, NV Lee, P Wang, PH Lo, PJ Koshy, PS Chockalingam, R Kelwick, RC Salter, RH Song, Richard Kelwick, RL Robker, RP Somerville, RP Somerville, RS Patel, S Abdul-Majeed, S Gerhardt, S Kumar, S Kumar, S Nandadasa, S Porter, S Porter, SS Apte, SS Glasson, T Fontanil, T Shindo, TN Wight, U Auf Dem Keller, W Du, W Zeng, WE Kutz, WM Wang, X Lu, X Pu, XL Zheng, YJ Liu, YP Hsu   +145 more
core   +1 more source

A small molecule inhibitor of leucine carboxyl methyltransferase-1 inhibits cancer cell survival

Frontiers in Drug Discovery
Reversible phosphorylation is the basis for signal transduction in eukaryotic cells, and this is tightly controlled by the complex interplay of kinases and phosphatases.
O. A. Arosarena, O. A. Arosarena, O. A. Arosarena, A. S. Saribas, E. P. Papadopoulos   +4 more
doaj   +1 more source

KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage [PDF]

, 2015
The Chk1 protein kinase is activated in response to DNA damage through ATR-mediated phosphorylation at multiple serine-glutamine (SQ) residues within the C-terminal regulatory domain, however the molecular mechanism is not understood. Modelling indicates
Freire, Raimundo, Fumagallo, Felipe, Gillespie, David A., Gong, Eun Yeung, Morrice, Nicholas, Piscitello, Desiree, Smits, Veronique A.J.   +6 more
core   +1 more source

The TriTryp Phosphatome: analysis of the protein phosphatase catalytic domains [PDF]

BMC Genomics, 2007
AbstractBackgroundThe genomes of the three parasitic protozoaTrypanosoma cruzi,Trypanosoma bruceiandLeishmania majorare the main subject of this study. These parasites are responsible for devastating human diseases known as Chagas disease, African sleeping sickness and cutaneous Leishmaniasis, respectively, that affect millions of people in the ...
Brenchley, Rachel, Tariq, Humera, McElhinney, Helen, Szöor, Balázs, Huxley-Jones, Julie, Stevens, Robert, Matthews, Keith, Tabernero, Lydia   +7 more
openaire   +5 more sources

Identification of residues in the heme domain of soluble guanylyl cyclase that are important for basal and stimulated catalytic activity. [PDF]

PLoS ONE, 2011
Nitric oxide signals through activation of soluble guanylyl cyclase (sGC), a heme-containing heterodimer. NO binds to the heme domain located in the N-terminal part of the β subunit of sGC resulting in increased production of cGMP in the catalytic domain
Padmamalini Baskaran, Erin J Heckler, Focco van den Akker, Annie Beuve   +3 more
doaj   +1 more source

Importance of the Domain−Domain Interface to the Catalytic Action of the NO Synthase Reductase Domain [PDF]

Biochemistry, 2008
Calmodulin (CaM) activates NO synthase (NOS) by binding to a 20 amino acid interdomain hinge in the presence of Ca (2+), inducing electrons to be transferred from the FAD to the heme of the enzyme via a mobile FMN domain. The activation process is influenced by a number of structural features, including an autoinhibitory loop, the C-terminal tail of ...
Welland, Andrew, Garnaud, Pierre E., Kitamura, Maki, Miles, Caroline S., Daff, Simon   +4 more
openaire   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Functional characterization of DYRK1A missense variants associated with a syndromic form of intellectual deficiency and autism

Biology Open, 2018
Haploinsufficiency of DYRK1A is a cause of a neurodevelopmental syndrome termed mental retardation autosomal dominant 7 (MRD7). Several truncation mutations, microdeletions and missense variants have been identified and result in a recognizable ...
Esti Wahyu Widowati, Sabrina Ernst, Ralf Hausmann, Gerhard Müller-Newen, Walter Becker   +4 more
doaj   +1 more source