Results 101 to 110 of about 724,446 (311)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Co-Mn-Al mixed oxides promoted by K for direct NO decomposition: Effect of preparation parameters [PDF]

, 2019
Fundamental research on direct NO decomposition is still needed for the design of a sufficiently active, stable and selective catalyst. Co-based mixed oxides promoted by alkali metals are promising catalysts for direct NO decomposition, but which ...
Balabánová, Jana, Bílková, Tereza, Fridrichová, Dagmar, Jirátová, Květa, Karásková, Kateřina, Kaspera, Wojciech, Kiška, Tomáš, Klegová, Anna, Kotarba, Andrzej, Koštejn, Martin, Obalová, Lucie, Pacultová, Kateřina, Stelmachowski, Paweł, Słowik, Grzegorz   +13 more
core   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Croton macrostachyus leaf-mediated biosynthesis of copper oxide nanoparticles for enhanced catalytic reduction of organic dyes

Materials Research Express
Introduction . Owing to the increasing use of organic dyes, the biosynthesis of metal oxide nanocatalysts is urgently needed as an economical and environmentally friendly solution to reduce their waste release. Method .
Atinafu Bergene Bassa, Osman Ahmed Zelekew, Tassew Alemayehu Meresa, Taame Abraha Berhe   +3 more
doaj   +1 more source

Decoration of Pt–Ni Alloy on Molten Salt Etched Halloysite Nanotubes for Enhanced Catalytic Reduction of 4-Nitrophenol

Separations
Efficient and low-cost nanocatalysts are extremely desirable for the catalytic reduction of 4-nitrophenol (4-NP). A smaller nanocatalyst particle size and stronger support effect can significantly enhance the catalytic performance.
Jingmin Duan, Yafei Zhao, Zhuhe Zhai, Shengqiang Chen, Bing Zhang   +4 more
doaj   +1 more source

A carbon dioxide reduction unit using Bosch reaction and expendable catalyst cartridges [PDF]

Catalytic carbon dioxide reduction cartridge for oxygen recovery in life support systems of long term manned space ...
Holmes, R. F., Keller, E. E., King, C. D.   +2 more
core   +1 more source

The stochastic quasi-steady-state assumption: Reducing the model but not the noise [PDF]

, 2011
Highly reactive species at small copy numbers play an important role in many biological reaction networks. We have described previously how these species can be removed from reaction networks using stochastic quasi-steady-state singular perturbation ...
Haseltine, Eric L., Mastny, Ethan, Rawlings, James B., Srivastava, Rishi   +3 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Electrochemical Characterization and DNA Interaction Studies of a Novel Copper Schiff Base Complex: Insights From Cyclic Voltammetry and Molecular Docking

Studia Universitatis Babes-Bolyai Chemia
In this study, we investigate the electrochemical properties of a novel copper complex (CuL2) derived from the Schiff base ligand N-3-bromopropylsalicylaldimine (LH).
Chahinaz ZOUBEIDI, Ali OURARI, Elhafnaoui LANEZ, Touhami LANEZ   +3 more
doaj   +1 more source

AuNPs-Based Thermoresponsive Nanoreactor as an Efficient Catalyst for the Reduction of 4-Nitrophenol

Nanomaterials, 2018
A new AuNPs-based thermosensitive nanoreactor (SiO2@PMBA@Au@PNIPAM) was designed and prepared by stabilizing AuNPs in the layer of poly(N,N’-methylenebisacrylamide) (PMBA) and subsequent wrapping with the temperature-sensitive poly(N ...
Wei Liu, Xiaolian Zhu, Chengcheng Xu, Zhao Dai, Zhaohui Meng   +4 more
doaj   +1 more source