Results 111 to 120 of about 8,702 (224)

Assessing narcolepsy with cataplexy in children and adolescents: development of a cataplexy diary and the ESS-CHAD

Nature and Science of Sleep, 2017
Y Grace Wang,1 Khadra Benmedjahed,2 Jérémy Lambert,2 Christopher J Evans,3 Steve Hwang,3 Jed Black,1,4 Murray W Johns5 1Clinical Development, Jazz Pharmaceuticals, Palo Alto, CA, USA; 2Patient-Centered Outcomes, Mapi, Lyon, France ...
Wang YG, Benmedjahed K, Lambert J, Evans CJ, Hwang S, Black J, Johns MW   +6 more
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Quickly diagnosed and treated prepubertal Type 1 narcolepsy case

Psychiatry and Clinical Psychopharmacology, 2018
Excessive daytime sleepiness, cataplexy, sleep paralysis, and hypnagogic hallucination are the classic tetrad of narcolepsy. It has been shown that narcolepsy, a chronic and disabling disease, starts in childhood and adolescence rather than adulthood ...
Fikret Poyraz Çökmüş, Orkun Aydın, Didem Sücüllüoğlu Dikici, Şermin Yalın Sapmaz   +3 more
doaj   +1 more source

Usefulness of genetic characterization of narcolepsy and hypersomnia on phenotype definition: a study in Portuguese patients [PDF]

, 2014
The determination of human leukocyte antigen (HLA) class II genotype is widely used to confirm the diagnosis of narcolepsy with or without cataplexy. The HLA genotyping is reliable, easy to perform and reassures the clinician.
Carvalho, Cláudia, Costa, Paulo P, Cunha, Daniela, Lopes, João, Martins-da-Silva, António, Ramalheira, João, Silva, M Berta   +6 more
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Correlation analysis between HLA-DQA1*0102/DQB1*0602 genotypes and narcolepsy patients in China

Frontiers in Neurology
Background and objectiveAt present, the etiology of narcolepsy is not fully understood, and it is generally believed to be an autoimmune reaction caused by interactions between environmental and genetic factors.
Wanyu Zhao, Baokun Zhang, Zian Yan, Mengke Zhao, Xiao Zhang, Xiaoyu Zhang, Xiaomin Liu, Jiyou Tang, Jiyou Tang   +8 more
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Narcolepsy: autoimmunity, effector T cell activation due to infection, or T cell independent, major histocompatibility complex class II induced neuronal loss? [PDF]

, 2017
Human narcolepsy with cataplexy is a neurological disorder, which develops due to a deficiency in hypocretin producing neurons in the hypothalamus. There is a strong association with human leucocyte antigens HLA-DR2 and HLA-DQB1*0602.
Bassetti, Claudio L., Birchler, Thomas, Fontana, Adriano, Gast, Heidemarie, Recher, Mike, Reith, Walter   +5 more
core  

Intravenous Immunoglobulin Therapy Administered Early after Narcolepsy Type 1 Onset in Three Patients Evaluated by Clinical and Polysomnographic Follow-Up

Behavioural Neurology, 2018
Narcolepsy type 1 is a rare disabling sleep disorder mainly characterized by excessive daytime sleepiness and cataplexy, an emotion-triggered sudden loss of muscle tone.
Elisabeth Ruppert, Hélène Zagala, Juliette Chambe, Henri Comtet, Ulker Kilic-Huck, François Lefebvre, Marc Bataillard, Carmen Schroder, Laurent Calvel, Patrice Bourgin   +9 more
doaj   +1 more source

Human Leukocyte Antigen-Typing in Patients with Excessive Daytime Sleepiness

Journal of Sleep Sciences, 2018
Background and Objective: Narcolepsy is a disorder recognized by excessive daytime sleepiness (EDS). Several studies demonstrated its association with human leukocyte antigen (HLA) DQB1*0602, DQA1*0102, and DRB1*15.
Khosro Sadeghniiat-Haghighi, Yadollah Shakiba, Omid Aminian, Ahmad Khajeh-mehrizi, Maryam Izad, Ania Rahimi-Golkhandan   +5 more
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Cataplexy

Scholarpedia, 2008
Christian Guilleminault, Michelle Cao
  +4 more sources

Issues related to differential diagnosis of epilepsy and narcolepsy

Эпилепсия и пароксизмальные состояния
A differential diagnosis of epileptic and non-epileptic paroxysms is particularly difficult to conduct during a neurologist consultation. Narcolepsy is a chronic disease that causes excessive daytime sleepiness.
E. A. Kantimirova, D. V. Dmitrenko
doaj   +1 more source

Rapid eye movement sleep muscle activity in routine polysomnography as a marker for narcolepsy

Sleep Research
Narcolepsy is a chronic neurological disorder characterized by excessive daytime sleepiness and associated symptoms, including cataplexy, sleep paralysis, hypnagogic/hypnopompic hallucinations, and disrupted nocturnal sleep.
Dhirendra Paudel, Yan Xu, Bin Zhang
doaj   +1 more source