Results 51 to 60 of about 9,873 (264)

Feeding-elicited cataplexy in orexin knockout mice [PDF]

, 2009
Mice lacking orexin/hypocretin signaling have sudden episodes of atonia and paralysis during active wakefulness. These events strongly resemble cataplexy, episodes of sudden muscle weakness triggered by strong positive emotions in people with narcolepsy,
Baumann, C R, Cano, G, Clark, E L, Mochizuki, T, Scammell, T E   +4 more
core   +1 more source

Age at Onset and Delays in Diagnosis of Central Disorders of Hypersomnolence Over the Past 30 Years

Journal of Sleep Research, EarlyView.
ABSTRACT Patients with narcolepsy type 1 (NT1), type 2 (NT2), idiopathic hypersomnia (IH) usually suffer from symptoms for years, even decades, before being diagnosed. We aimed to assess age at onset, age at diagnosis and changes in the diagnostic delays of these patients from 1990 to 2020 in a single centre.
Zhongxing Zhang, Lucie Barateau, Séverine Béziat, Ramin Khatami, Yves Dauvilliers   +4 more
wiley   +1 more source

Once‐Nightly Sodium Oxybate Meets American Academy of Sleep Medicine Criteria for Treatment of Narcolepsy

Journal of Sleep Research, EarlyView.
ABSTRACT Data from the REST‐ON trial were not available before the 2021 American Academy of Sleep Medicine (AASM) clinical practice guideline update, which included a literature review through August 2020. This post hoc analysis from REST‐ON assessed participants who achieved clinically significant improvements on individual AASM clinical significance ...
Luis E. Ortiz, Anne Marie Morse, Michael J. Thorpy, Clete A. Kushida, John Harsh, Thomas Roth, Jennifer Gudeman, Yves Dauvilliers   +7 more
wiley   +1 more source

Brazilian guidelines for the treatment of narcolepsy [PDF]

, 2010
Este artigo relata as conclusões da reunião de consenso com médicos especialistas sobre diagnóstico de narcolepsia baseada na revisão dos artigos sobre narcolepsia listados no Medline entre 1980 e 2010.
Alves, Rosana Cardoso, Alóe, Flávio, Araújo, John Fontenele, Azevedo, Alexandre, Bacelar, Andrea, Bezerra, Márcio, Bittencourt, Lia Rita Azeredo, Bustamante, Guilherme, Cardoso, Tânia Aparecida Marchiori de Oliveira, Eckeli, Alan Luiz, Fernandes, Regina Maria França, Goulart, Leonardo, Hasan, Rosa, Lopes, Maria Cecília, Minhoto, Gisele Richter, Moraes, Walter, Moreira, Gustavo Antônio, Pachito, Daniela, Pedrazolli Neto, Mário, Pinto Júnior, Luciano Ribeiro, Poyares, Dalva Lúcia Rollemberg, Pradella-Hallinan, Márcia, Prado, Lucila, Rizzo, Geraldo, Rodrigues, Raimundo Nonato Delgado, Roitman, Israel, Sander, Heidi Haueisen, Silva, Ademir Baptista, Tavares, Stella Márcia Azevedo   +28 more
core   +4 more sources

Automatic detection of cataplexy [PDF]

Sleep Medicine, 2018
Although being the most specific symptom of narcolepsy type 1 (NT1), cataplexy is currently investigated by clinical interview only, with potential diagnostic pitfalls. Our study aimed at testing the accuracy of an automatic video detection of cataplexy in NT1 patients vs.
Bartolini, Ilaria, Pizza, Fabio, Di Luzio, Andrea, Neccia, Giulia, Antelmi, Elena, Vandi, Stefano, Plazzi, Giuseppe   +6 more
openaire   +2 more sources

Facial Emotion Recognition in Children With Narcolepsy Type 1

Journal of Sleep Research, EarlyView.
ABSTRACT Narcolepsy type 1 is a neurological disorder typically emerging in childhood or adolescence, characterised by excessive daytime sleepiness, cataplexy and rapid eye movement sleep‐related symptoms. Beyond its core features, increasing evidence suggests an impact on socio‐cognitive development, including difficulties in understanding others ...
Marco Veneruso, Paola Del Sette, Ramona Cordani, Antonella Barbieri, Lorenzo Chiarella, Serena Lecce, Cristina Venturino, Salvatore Lo Cascio, Francesco Biscarini, Fabio Pizza, Lino Nobili, Giuseppe Plazzi   +11 more
wiley   +1 more source

Narcolepsy [PDF]

, 2007
BACKGROUND: Narcolepsy is a chronic neurological syndrome with prevalence between 0.018% and 0.040% without important ethnic differences. Narcolepsy is characterized by excessive daytime sleepiness and cataplexy. The pathophysiology of the illness is not
Bittencourt, Lia Rita Azeredo, Coelho, Fernando Morgadinho Santos, Elias, Rosilene Motta, Pradella-Hallinan, Márcia Lurdes de Cássia, Tufik, Sergio   +4 more
core   +3 more sources

Baclofen for narcolepsy with cataplexy: two cases

Nature and Science of Sleep, 2015
Elliott Kyung Lee,1,2 Alan Bruce Douglass1,2 1Department of Psychiatry, Faculty of Medicine, Institute of Mental Health Research, University of Ottawa, 2Royal Ottawa Mental Health Center, Ottawa, ON, Canada Abstract: Narcolepsy is a disabling sleep ...
Lee EK, Douglass AB
doaj  

Cataplexy response with extended-release once-nightly sodium oxybate: Post hoc responder analyses from the phase 3 REST-ON clinical trial

Sleep Medicine: X
Background: Once-nightly sodium oxybate (ON-SXB), an extended-release oxybate formulation, yielded significant (P 
Michael J. Thorpy, Clete A. Kushida, Richard Bogan, Akinyemi O. Ajayi, Bruce C. Corser, Jennifer Gudeman   +5 more
doaj   +1 more source

TNF and IL-6 levels in narcoleptic patients [PDF]

Einstein (São Paulo), 2006
Objective: To evaluate the presence of HLA-DQB1*0602 allele, tumornecrosis factor and interleukin-6 in patients with cataplexy andcontrols. Methods: A prospective controlled study with 22 patientsdiagnosed as narcoleptic according to DSM4 criteria and 17
Fernando Morgadinho Santos Coelho, Heraldo Possolo de Sousa, Gabriela Rodrigues Alves, Lia Rita Azeredo Bittencourt, Márcia Pradella-Hallinan, Fábio Moreira, Mário Pedrazzoli Neto, Sérgio Tufik   +7 more
doaj