Results 81 to 90 of about 8,772 (223)

Microbial‐Immune Interplay in CNS Autoimmune Diseases: Lessons from Animal Models and Clinical Studies

European Journal of Immunology, Volume 56, Issue 2, February 2026.
Mechanism of action of the intestinal microbiota on CNS autoimmune diseases. Environmental factors shape gut microbiota composition; dysbiosis alters microbial metabolites and antigenic signals. These modulate innate and adaptive immunity, affect barrier integrity, and influence CNS‐resident cells such as microglia and astrocytes, contributing to ...
Matteo Ceccon, Francesca Ronchi
wiley   +1 more source

Narcolepsy patients have antibodies that stain distinct cell populations in rat brain and influence sleep patterns. [PDF]

, 2014
Narcolepsy is a chronic sleep disorder, likely with an autoimmune component. During 2009 and 2010, a link between A(H1N1)pdm09 Pandemrix vaccination and onset of narcolepsy was suggested in Scandinavia.
A. Cederlund, A. Huutoniemi, Adamantidis, Ahnaou, Aran, B. Agerberth, B. Horvath, Beuckmann, Bittencourt, C. Adori, Chastrette, Conzelmann, Cvetkovic-Lopes, D. Kostyalik, Dauvilliers, David, de Lecea, Diniz Behn, Frisullo, G. Bagdy, Gao, Geis, Gonzalez-Albo, Hallmayer, Han, Hara, Hublin, I. Julkunen, Israeli, Kantor, Kitka, Konadhode, Koo, Kornum, L. Kalmar, Li, Longstreth, M. Partinen, Maulon-Feraille, Mignot, NAHON, Overeem, P. Bergman, Panskepp, Partinen, Peyron, Peyron, Qiu, Rao, Rovere, S. Vas, Sakurai, Saper, Saper, Sasaki, Scammell, T. Hokfelt, T. Sarkanen, Tamamaki, Thannickal, Tsunematsu, van den Pol, Verret, Viale, Watson, Y. Kai-Larsen, Zhang   +66 more
core   +1 more source

Abnormal activity in hypothalamus and amygdala during humour processing in human narcolepsy with cataplexy [PDF]

, 2017
Narcolepsy with cataplexy (NC) is a complex sleep-wake disorder, which was recently found to be associated with a reduction or loss of hypocretin (HCRT, also called orexin). HCRT is a hypothalamic peptide implicated in the regulation of sleep/wake, motor
Bassetti, C L., Boesiger, P., Khatami, R., Ponz, A., Poryazova, R., Schwartz, S., Werth, E.   +6 more
core  

Idling for Decades: A European Study on Risk Factors Associated with the Delay Before a Narcolepsy Diagnosis

Nature and Science of Sleep, 2022
Zhongxing Zhang,1 Yves Dauvilliers,2– 4 Giuseppe Plazzi,5,6 Geert Mayer,7 Gert Jan Lammers,8,9 Joan Santamaria,10 Markku Partinen,11 Sebastiaan Overeem,12,13 Rafael del Rio Villegas,14 Karel Sonka,15 Rosa Peraita-Adrados,16 Raphaël Heinzer,17 Aleksandra ...
Zhang Z, Dauvilliers Y, Plazzi G, Mayer G, Lammers GJ, Santamaria J, Partinen M, Overeem S, del Rio Villegas R, Sonka K, Peraita-Adrados R, Heinzer R, Wierzbicka A, Högl B, Manconi M, Feketeova E, da Silva AM, Bušková J, Bassetti CLA, Barateau L, Pizza F, Antelmi E, Gool JK, Fronczek R, Gaig C, Khatami R   +25 more
doaj  

Brazilian guidelines for the treatment of narcolepsy [PDF]

, 2010
Este artigo relata as conclusões da reunião de consenso com médicos especialistas sobre diagnóstico de narcolepsia baseada na revisão dos artigos sobre narcolepsia listados no Medline entre 1980 e 2010.
Alves, Rosana Cardoso, Alóe, Flávio, Araújo, John Fontenele, Azevedo, Alexandre, Bacelar, Andrea, Bezerra, Márcio, Bittencourt, Lia Rita Azeredo, Bustamante, Guilherme, Cardoso, Tânia Aparecida Marchiori de Oliveira, Eckeli, Alan Luiz, Fernandes, Regina Maria França, Goulart, Leonardo, Hasan, Rosa, Lopes, Maria Cecília, Minhoto, Gisele Richter, Moraes, Walter, Moreira, Gustavo Antônio, Pachito, Daniela, Pedrazolli Neto, Mário, Pinto Júnior, Luciano Ribeiro, Poyares, Dalva Lúcia Rollemberg, Pradella-Hallinan, Márcia, Prado, Lucila, Rizzo, Geraldo, Rodrigues, Raimundo Nonato Delgado, Roitman, Israel, Sander, Heidi Haueisen, Silva, Ademir Baptista, Tavares, Stella Márcia Azevedo   +28 more
core   +4 more sources

Pitolisant to Treat Excessive Daytime Sleepiness and Cataplexy in Adults with Narcolepsy: Rationale and Clinical Utility

Nature and Science of Sleep, 2020
Jay T Guevarra, Robert Hiensch, Andrew W Varga, David M Rapoport Division of Pulmonary, Critical Care, and Sleep Medicine, Mount Sinai Integrative Sleep Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USACorrespondence: Jay T ...
Guevarra JT, Hiensch R, Varga AW, Rapoport DM   +3 more
doaj  

GHB’s Path to Legitimacy: An Administrative and Legislative History of Xyrem [PDF]

, 2012
This paper traces the path of a chemical compound (gamma-hydroxybutyrate, or GHB) from its status as an abused street drug to that of a legitimate, life-altering prescription treatment for a debilitating condition.
Neuman, Ariel
core  

Narcolepsy and Cataplexy

Pediatric Neurology Briefs, 1998
The clinical manifestations and treatment of narcolepsy diagnosed in 51 prepubertal children (29 boys) are reported from the Stanford Sleep Disorder Clinic, Stanford University Medical Center, CA.
J Gordon Millichap
doaj   +1 more source

Orexin Receptor Antagonism, a New Sleep-Enabling Paradigm: A Proof-of-Concept Clinical Trial [PDF]

, 2012
Peer ...
Barbanoj, M. J., Bassetti, C. L., Benes, H., Bengtsson, H., Berg, S., Chiossi, E., Danker-Hopfe, H., Dingemanse, J., Dorffner, G., Ebrahim, I. O., Hajak, G., Hemmeter, U-M, Hoegl, B., Hoever, P., Holsboer-Trachsler, E., Kunz, D., Partinen, M., Peker, Y., Penzel, T., Pillar, G., Polo, O., Saletu, B., Zeitlhofer, J.   +22 more
core   +2 more sources

Narcolepsy in early childhood: a case report and a Mini review

Frontiers in Pediatrics
Narcolepsy is a sleep-wake disorder with an onset commonly seen in individuals aged 10–30 years. Due to various reasons, the diagnosis of narcolepsy often experiences a delay of at least ten years.
Guorui Liu, Guorui Liu, Guanxiong Li, Yihao Wang, Ming Yin, Wen Pan, Yu Zhao, Shigeng Gao, Peiqi Shi, Jing Wen, Xiao Pan, Yajing Wang, Yanfei Zhang   +12 more
doaj   +1 more source