Results 121 to 130 of about 2,348,941 (273)
Theory and Applications of Categories, 2008 Some aspects of basic category theory are developed in a finitely complete category $\C$, endowed with two factorization systems which determine the same discrete objects and are linked by a simple reciprocal stability law. Resting on this axiomatization of final and initial functors and discrete (op)fibrations, concepts such as components, slices and ...
openaire +3 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Category Theory for Autonomous and Networked Dynamical Systems. [PDF]
Entropy (Basel), 2019 Delvenne JC.
europepmc +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Foundations of reusable and interoperable facet models using category theory. [PDF]
Inf Syst Front, 2016 Harris DR.
europepmc +1 more source
FEBS Open Bio, EarlyView.We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima +4 more
wiley +1 more source
Towards a category theory approach to analogy: Analyzing re-representation and acquisition of numerical knowledge. [PDF]
PLoS Comput Biol, 2017 Navarrete JA, Dartnell P.
europepmc +1 more source
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
Modeling Reusable and Interoperable Faceted Browsing Systems with Category Theory. [PDF]
Proc IEEE Int Conf Inf Reuse Integr, 2015 Harris DR.
europepmc +1 more source