Results 121 to 130 of about 9,368,793 (360)
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Homotopy Theory in Abelian Categories [PDF]
Canadian Journal of Mathematics, 1962 The concept of homotopy for homomorphisms of modules, suggested by analogy with fundamental properties of the topological homotopy, was developed by Eckmann and Hilton (3; 9; 10). In the present paper, this concept of homotopy is generalized to additive categories with an additional structure, and the theory of homotopy, including in particular various
openaire +3 more sources
Molecular Oncology, EarlyView.There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes +20 more
wiley +1 more source
Ring completion of rig categories
, 2009 We offer a solution to the long-standing problem of group completing within the context of rig categories (also known as bimonoidal categories). Given a rig category R we construct a natural additive group completion R' that retains the multiplicative ...
Baas, Nils A. +3 more
core +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
On the validity of the definition of a complement-classifier
Zagadnienia Filozoficzne w Nauce, 2020 It is well-established that topos theory is inherently connected with intuitionistic logic. In recent times several works appeared concerning so-called complement-toposes (co-toposes), which are allegedly connected to the dual to intuitionistic logic. In
Mariusz Stopa
doaj
ON ‘CATEGORIES’ OF QUANTUM FIELD THEORIES [PDF]
Proceedings of the International Congress of Mathematicians (ICM 2018), 2019 We give a rough description of the 'categories' formed by quantum field theories. A few recent mathematical conjectures derived from quantum field theories, some of which are now proven theorems, will be presented in this language.
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