Results 171 to 180 of about 8,086,442 (367)

Using Kan Extensions to Motivate the Design of a Surprisingly Effective Unsupervised Linear SVM on the Occupancy Dataset

open access: yesMathematical and Computational Applications
Recent research has suggested that category theory can provide useful insights into the field of machine learning (ML). One example is improving the connection between an ML problem and the design of a corresponding ML algorithm.
Matthew Pugh   +3 more
doaj   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

Recognizing early MRI signs (or their absence) is crucial in diagnosing metachromatic leukodystrophy

open access: yesAnnals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1999-2009, December 2022., 2022
Abstract Objectives Metachromatic leukodystrophy (MLD) has characteristic white matter (WM) changes on brain MRI, which often trigger biochemical and genetic confirmation of the diagnosis. In early or pre‐symptomatic disease stages, these typical MRI changes might be absent, hampering early diagnosis.
Daphne H. Schoenmakers   +7 more
wiley   +1 more source

Using Relational Biology with Loop Analysis to Study the North Atlantic Biological Carbon Pump in a ‘Hybrid’ Non-Algorithmic Manner

open access: yesMathematics
Biologists, philosophers, and mathematicians building upon Robert Rosen’s non-algorithmic theories of life using Relational Biology and Category Theory have continued to develop his theory and modeling approaches.
Patricia A. Lane
doaj   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

The anterior nucleus of the thalamus plays a role in the epileptic network

open access: yesAnnals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2010-2024, December 2022., 2022
Abstract Objectives We investigated both the metabolic differences and interictal/ictal discharges of the anterior nucleus of the thalamus (ANT) in patients with epilepsy to clarify the relationship between the ANT and the epileptic network. Methods Nineteen patients with drug‐resistant epilepsy who underwent stereoelectroencephalography were studied ...
Hao Yan   +9 more
wiley   +1 more source

Semantic Categories: Uncertainty and Similarity

open access: yesMathematical and Computational Applications
This paper addresses understanding and categorizing language by using Markov categories to establish a mathematical framework for semantic concepts. This framework enables us to measure the semantic similarity between linguistic expressions within a ...
Ares Fabregat-Hernández   +2 more
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Localization theory for triangulated categories

open access: yes, 2010
These notes provide an introduction to the theory of localization for triangulated categories. Localization is a machinery to formally invert morphisms in a category. We explain this formalism in some detail and we show how it is applied to triangulated categories.
openaire   +3 more sources

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