Results 71 to 80 of about 2,348,941 (273)

MENS, an Info-Computational Model for (Neuro-)cognitive Systems Capable of Creativity

Entropy, 2012
MENS is a bio-inspired model for higher level cognitive systems; it is an application of the Memory Evolutive Systems developed with Vanbremeersch to model complex multi-scale, multi-agent self-organized systems, such as biological or social systems. Its
Andrée C. Ehresmann
doaj   +1 more source

Homotopy theory with *-categories

Theory and Applications of Categories, 2019
We construct model category structures on various types of (marked) *-categories. These structures are used to present the infinity categories of (marked) *-categories obtained by inverting (marked) unitary equivalences. We use this presentation to explicitly calculate the \infty-categorical G-fixed points and G-orbits for G-equivariant (marked ...
openaire   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Level-Agnostic Representations of Interacting Agents

Mathematics
The study of the interactions among intentional agents, with rationality being the main source of intentional behavior, requires mathematical tools capable of capturing systemic effects. Here, we choose an alternative toolbox based on Category Theory. We
Fernando Tohmé, Andrés Fioriti
doaj   +1 more source

Paranatural Category Theory

, 2023
We establish and advocate for a novel branch of category theory, centered around strong dinatural transformations (herein known as "paranatural transformations"). Paranatural transformations generalize natural transformations to mixed-variant difunctors, but, unlike other such generalizations, are composable and exceptionally well-behaved.
openaire   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Robert Rosen’s Relational Biology Theory and His Emphasis on Non-Algorithmic Approaches to Living Systems

Mathematics
This paper examines the use of algorithms and non-algorithmic models in mathematics and science, especially in biology, during the past century by summarizing the gradual development of a conceptual rationale for non-algorithmic models in biology. First,
Patricia A. Lane
doaj   +1 more source

A General Framework for the Semantics of Type Theory

, 2019
We propose an abstract notion of a type theory to unify the semantics of various type theories including Martin-L\"{o}f type theory, two-level type theory and cubical type theory.
Uemura, Taichi
core  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source